2. Gene
  3. TIAL1 - TIA1 cytotoxic granule associated RNA binding protein like 1 Gene

TIAL1 - TIA1 cytotoxic granule associated RNA binding protein like 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TIA1 细胞毒性颗粒相关 RNA 结合蛋白样 1

种属: Homo sapiens

同用名: TCBP; TIAR

基因 ID: 7073 | 基因类型: protein coding

关于 TIAL1

Cytogenetic location: 10q26.11 Genomic coordinates (GRCh38): 10:119,573,465-119,596,964 (from NCBI)

This gene has 13 transcripts (splice variants), 116 orthologues and 36 paralogues. Ubiquitous expression in endometrium (RPKM 14.6), lymph node (RPKM 14.0) and 25 other tissues.

功能概要

该基因编码的蛋白质是 RNA 结合蛋白家族的一员，具有三个 RNA 识别基序 (RRM) ，并结合多种基因的 mRNA 和 pre-mRNA 中富含腺嘌呤和尿苷的元素。它调节各种活动，包括翻译控制、剪接和细胞凋亡。已经表征了编码不同亚型的替代转录剪接变体。不同的亚型已显示在转录后沉默方面的功能不同。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and Apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]

TIAL1 基因产物(8)

mRNA Protein Name
NM_001033925.2 NP_001029097.1 nucleolysin TIAR isoform 2
NM_001323964.2 NP_001310893.1 nucleolysin TIAR isoform 3
NM_001323965.2 NP_001310894.1 nucleolysin TIAR isoform 3
NM_001323967.2 NP_001310896.1 nucleolysin TIAR isoform 3
NM_001323968.2 NP_001310897.1 nucleolysin TIAR isoform 4
NM_001323969.2 NP_001310898.1 nucleolysin TIAR isoform 5
NM_001323970.2 NP_001310899.1 nucleolysin TIAR isoform 6
NM_003252.4 NP_003243.1 nucleolysin TIAR isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables mRNA 3'-UTR binding IDA
IDA: 通过直接分析推断
33203680 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
enables protein-RNA adaptor activity IDA
IDA: 通过直接分析推断
33203680 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
33203680 GOA
involved in positive regulation of hippo signaling IMP
IMP: 通过突变表型推断
33203680 GOA
involved in positive regulation of miRNA-mediated gene silencing IGI
IGI: 通过遗传相互作用推断
33203680 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TIAL1 蛋白结构

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (11 - 79)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (99 - 169)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (207 - 271)

  • 0
  • 100
  • 200
  • 300
  • 375 a.a.
蛋白主名 其他名称

nucleolysin TIAR

T-cluster binding protein

TIAL1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TIAL1 Q01085 MOV10 Homo sapiens Q9HCE1
Anti Bait CoIP
34517762
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Ulcerative Blepharitis
Salpingitis Isthmica Nodosa
Muscular Atrophy

Muscle Wasting

Amyotrophia

Wasting - Muscle

Skeletal Muscle Atrophy
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14514 TIAL1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14520 TIE1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-15973 BSF-466895 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus TIAL1 VGNC VGNC:35859
Rattus norvegicus TIAL1 RGD RGD:1595845
Macaca mulatta TIAL1 VGNC VGNC:78354
Mus musculus TIAL1 MGD MGI:107913
Canis familiaris TIAL1 VGNC VGNC:47364
Felis catus TIAL1 VGNC VGNC:66182
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