2. Gene
  3. PCGF2 - polycomb group ring finger 2 Gene

PCGF2 - polycomb group ring finger 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Polycomb 组无名指 2

种属: Homo sapiens

同用名: TPFS; MEL-18; RNF110; ZNF144

基因 ID: 7703 | 基因类型: protein coding

关于 PCGF2

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:38,733,898-38,749,792 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 180 orthologues, 7 paralogues and is associated with 3 phenotypes. Ubiquitous expression in kidney (RPKM 9.0), thyroid (RPKM 6.9) and 24 other tissues.

功能概要

该基因编码的蛋白质含有环指基序，类似于多梳组 (PcG) 基因产物。 PcG 基因产物通过蛋白质-蛋白质相互作用形成复合物，并维持参与胚胎发生、细胞周期和肿瘤发生的基因的转录抑制。该蛋白质被证明可作为转录的负调节因子并具有肿瘤抑制活性。该基因在多种肿瘤细胞中均有表达，但仅限于正常组织的神经器官中表达。小鼠基因敲除研究表明，该蛋白可能负向调节不同细胞因子、趋化因子和趋化因子受体的表达，因此在淋巴细胞分化和迁移以及免疫反应中发挥重要作用。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq, Jul 2008]

PCGF2 基因产物(3)

mRNA Protein Name
NM_001369614.1 NP_001356543.1 polycomb group RING finger protein 2
NM_001369615.1 NP_001356544.1 polycomb group RING finger protein 2
NM_007144.3 NP_009075.1 polycomb group RING finger protein 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19636380 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chromatin remodeling IMP
IMP: 通过突变表型推断
26151332 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
19636380 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of PRC1 complex IDA
IDA: 通过直接分析推断
19636380 GOA
part of PcG protein complex IDA
IDA: 通过直接分析推断
21282530 GOA
located in chromatin IDA
IDA: 通过直接分析推断
19636380 GOA
located in nucleus IDA
IDA: 通过直接分析推断
21282530 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PCGF2 蛋白结构

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (18 - 56)

  • 0
  • 100
  • 200
  • 300
  • 344 a.a.
蛋白主名 其他名称

polycomb group RING finger protein 2

DNA-binding protein Mel-18

PCGF2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PCGF2 P35227 USP7 Homo sapiens Q93009
Pull Down
20601937
Intra PCGF2 P35227 USP7 Homo sapiens Q93009
Anti Tag CoIP
20601937
Intra PCGF2 P35227 USP7 Homo sapiens Q93009
TAP
20601937
Intra PCGF2 P35227 USP11 Homo sapiens P51784
Anti Tag CoIP
20601937
Intra PCGF2 P35227 USP11 Homo sapiens P51784
Pull Down
20601937
Intra PCGF2 P35227 USP11 Homo sapiens P51784
TAP
20601937
Intra PCGF2 P35227 UBC Homo sapiens P0CG48
Pull Down
20601937
Intra PCGF2 P35227 UBC Homo sapiens P0CG48
TAP
20601937
Intra PCGF2 P35227 TRAF2 Homo sapiens Q12933
Validated Y2H
32296183
Intra PCGF2 P35227 CBX7 Homo sapiens O95931
Anti Tag CoIP
33961781
Intra PCGF2 P35227 CBX7 Homo sapiens O95931
TAP
27705803
Intra PCGF2 P35227 CBX7 Homo sapiens O95931
Anti Tag CoIP
28514442
Intra PCGF2 P35227 CBX6 Homo sapiens O95503
Anti Tag CoIP
33961781
Intra PCGF2 P35227 CBX6 Homo sapiens O95503
Anti Tag CoIP
28514442
Intra PCGF2 P35227 CBX6 Homo sapiens O95503
TAP
27705803
Intra PCGF2 P35227 PELI2 Homo sapiens Q9HAT8
Validated Y2H
32296183
Intra PCGF2 P35227 CBX8 Homo sapiens Q9HC52
Anti Bait CoIP
19636380
Intra PCGF2 P35227 CBX8 Homo sapiens Q9HC52
Anti Tag CoIP
33961781
Intra PCGF2 P35227 CBX8 Homo sapiens Q9HC52
TAP
19636380
Intra PCGF2 P35227 CBX8 Homo sapiens Q9HC52
TAP
20601937
Intra PCGF2 P35227 CBX8 Homo sapiens Q9HC52
Anti Tag CoIP
19636380
Intra PCGF2 P35227 CBX8 Homo sapiens Q9HC52
TAP
27705803
Intra PCGF2 P35227 CBX8 Homo sapiens Q9HC52
Pull Down
21282530
Intra PCGF2 P35227 CBX8 Homo sapiens Q9HC52
Anti Tag CoIP
28514442
Intra PCGF2 P35227 PHC2 Homo sapiens Q8IXK0
TAP
19636380
Intra PCGF2 P35227 PHC2 Homo sapiens Q8IXK0
TAP
27705803
Intra PCGF2 P35227 PHC2 Homo sapiens Q8IXK0
Anti Tag CoIP
33961781
Intra PCGF2 P35227 PHC2 Homo sapiens Q8IXK0
TAP
20601937
Intra PCGF2 P35227 PHC2 Homo sapiens Q8IXK0
Y2H Prey Pooling
25416956
Intra PCGF2 P35227 PHC2 Homo sapiens Q8IXK0
Anti Bait CoIP
19636380
Intra PCGF2 P35227 RNF2 Homo sapiens Q99496
Anti Bait CoIP
19636380
Intra PCGF2 P35227 RNF2 Homo sapiens Q99496
Anti Tag CoIP
22493164
Intra PCGF2 P35227 RNF2 Homo sapiens Q99496
TAP
19636380
Intra PCGF2 P35227 RNF2 Homo sapiens Q99496
TAP
20601937
Intra PCGF2 P35227 RNF2 Homo sapiens Q99496
TAP
27705803
Intra PCGF2 P35227 RNF2 Homo sapiens Q99496
Validated Y2H
32296183
Intra PCGF2 P35227 RNF2 Homo sapiens Q99496
Anti Tag CoIP
33961781
Intra PCGF2 P35227 RNF2 Homo sapiens Q99496
Y2H Array
22493164
Intra PCGF2 P35227 RNF2 Homo sapiens Q99496
Y2H Array
32296183
Intra PCGF2 P35227 RNF2 Homo sapiens Q99496
Anti Tag CoIP
28514442
Intra PCGF2 P35227 RNF2 Homo sapiens Q99496
Y2H Prey Pooling
32296183
Intra PCGF2 P35227 PHC1 Homo sapiens P78364
TAP
19636380
Intra PCGF2 P35227 PHC1 Homo sapiens P78364
Anti Tag CoIP
33961781
Intra PCGF2 P35227 PHC1 Homo sapiens P78364
TAP
20601937
Intra PCGF2 P35227 PHC1 Homo sapiens P78364
TAP
27705803
Intra PCGF2 P35227 PHC1 Homo sapiens P78364
Anti Tag CoIP
28514442
Intra PCGF2 P35227 PHC1 Homo sapiens P78364
Validated Y2H
32296183
Intra PCGF2 P35227 RING1 Homo sapiens Q06587
Anti Tag CoIP
33961781
Intra PCGF2 P35227 RING1 Homo sapiens Q06587
TAP
20601937
Intra PCGF2 P35227 RING1 Homo sapiens Q06587
TAP
27705803
Intra PCGF2 P35227 RING1 Homo sapiens Q06587
TAP
19636380
Intra PCGF2 P35227 RING1 Homo sapiens Q06587
Validated Y2H
32296183
Intra PCGF2 P35227 RING1 Homo sapiens Q06587
Y2H Array
22493164
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Turnpenny-Fry Syndrome

TPFS

Neurocardioskeletal Syndrome
Pontocerebellar Hypoplasia, Type 13

PCH13

Pontocerebellar Hypoplasia Type 13

Pontocerebellar Hypoplasia 13

Doid:0112332

Hypoplasia, Pontocerebellar, Type 13
Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma

Hodgkin Disease

Hodgkin'S Lymphoma

Hodgkins Lymphoma

Classic Hodgkin Lymphoma

CHL

Hodgkin Lymphoma, Susceptibility To

Hl

Hodgkin'S Sarcoma

Stage I Subdiaphragmatic Hodgkin Lymphoma

Stage Ii Subdiaphragmatic Hodgkin Lymphoma

Lymphoma, Hodgkin'S

Classic Hodgkin Disease

Hodgkin'S Disease

Lymphoma, Hodgkin, Susceptibility To

Hodgkin'S Disease Of Intrapelvic Lymph Nodes

Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb

Malignant Lymphogranuloma

Malignant Lymphogranulomatosis

Malignant Hodgkin Lymphoma

Classical Hodgkin Lymphoma, Type Not Specified
Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Medulloblastoma Predisposition Syndrome

Medulloblastoma, Somatic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Neuroectodermal Tumors, Primitive

Medulloblastomas

Desmoplastic Medulloblastoma

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10146 PCGF2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PCGF2 RGD RGD:1305097
Macaca mulatta PCGF2 VGNC VGNC:104640
Felis catus PCGF2 VGNC VGNC:64066
Mus musculus PCGF2 MGD MGI:99161
Canis familiaris PCGF2 VGNC VGNC:44301
Bos taurus PCGF2 VGNC VGNC:32627
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