RNF2 - ring finger protein 2 Gene

中文名称：无名指蛋白 2

种属: Homo sapiens

同用名: BAP1; DING; BAP-1; HIPI3; RING2; LUSYAM; RING1B

关于 RNF2

功能概要

蛋白质的多梳组 (PcG) 形成多蛋白复合物，对于参与发育和细胞增殖的各种基因的转录抑制很重要。该基因编码的蛋白质是 PcG 蛋白之一。它已被证明与转录因子 CP2 (TFCP2/CP2) 相互作用并抑制其活性。小鼠对应物的研究表明该基因参与前后轴的规范，以及早期发育中的细胞增殖。还发现该蛋白质与泛素结合酶亨廷顿相互作用蛋白 2 (HIP2) 相互作用，并具有泛素连接酶活性。[RefSeq 提供，2008 年 7 月]

Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with Huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating Enzyme, and possess ubiquitin Ligase activity. [provided by RefSeq, Jul 2008]