2. Gene
  3. KAT8 - lysine acetyltransferase 8 Gene

KAT8 - lysine acetyltransferase 8 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：赖氨酸乙酰转移酶 8

种属: Homo sapiens

同用名: MOF; hMOF; MYST1; LIGOWS; ZC2HC8

基因 ID: 84148 | 基因类型: protein coding

关于 KAT8

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:31,117,664-31,131,393 (from NCBI)

This gene has 8 transcripts (splice variants), 189 orthologues, 9 paralogues and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 17.1), testis (RPKM 11.9) and 25 other tissues.

功能概要

该基因编码 MYST 组蛋白乙酰化酶蛋白家族的成员。编码的蛋白质具有包含乙酰辅酶 A 结合位点的特征性 MYST 结构域、结合组蛋白的典型蛋白质染色域和 C2HC 型锌指。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2012 年 2 月]

This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

KAT8 基因产物(2)

mRNA Protein Name
NM_032188.3 NP_115564.2 histone acetyltransferase KAT8 isoform 1
NM_182958.4 NP_892003.2 histone acetyltransferase KAT8 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
IDA: 通过直接分析推断
11965546 GOA
enables histone H4 acetyltransferase activity IDA
IDA: 通过直接分析推断
27382063 GOA
contributes to histone H4K16 acetyltransferase activity IDA
IDA: 通过直接分析推断
20018852 GOA
enables histone H4K16 acetyltransferase activity IDA
IDA: 通过直接分析推断
21217699 GOA
contributes to histone H4K5 acetyltransferase activity IDA
IDA: 通过直接分析推断
20018852 GOA
enables histone H4K5 acetyltransferase activity IDA
IDA: 通过直接分析推断
27768893 GOA
contributes to histone H4K8 acetyltransferase activity IDA
IDA: 通过直接分析推断
20018852 GOA
enables histone H4K8 acetyltransferase activity IDA
IDA: 通过直接分析推断
27768893 GOA
enables peptide-lysine-N-acetyltransferase activity IDA
IDA: 通过直接分析推断
17189187 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11742995 GOA
enables protein propionyltransferase activity IDA
IDA: 通过直接分析推断
29321206 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
11742995 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in myeloid cell differentiation IDA
IDA: 通过直接分析推断
11742995 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
11742995 GOA
involved in negative regulation of epithelial to mesenchymal transition IDA
IDA: 通过直接分析推断
27292636 GOA
involved in neurogenesis IDA
IDA: 通过直接分析推断
31794431 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
11742995 GOA
involved in positive regulation of transcription initiation by RNA polymerase II IDA
IDA: 通过直接分析推断
33657400 GOA
acts upstream of or within regulation of autophagy IDA
IDA: 通过直接分析推断
23863932 GOA
involved in regulation of mRNA processing IDA
IDA: 通过直接分析推断
37369679 GOA
involved in regulation of mitochondrial transcription IDA
IDA: 通过直接分析推断
27768893 GOA
involved in transcription initiation-coupled chromatin remodeling IMP
IMP: 通过突变表型推断
15960975 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of MLL1 complex IDA
IDA: 通过直接分析推断
15960975 GOA
part of MSL complex IDA
IDA: 通过直接分析推断
20018852 GOA
part of NSL complex IDA
IDA: 通过直接分析推断
19854137 GOA
is active in chromosome IDA
IDA: 通过直接分析推断
33657400 GOA
part of histone acetyltransferase complex IDA
IDA: 通过直接分析推断
20018852 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
27768893 GOA
is active in nucleus IDA
IDA: 通过直接分析推断
28991411 GOA
located in nucleus IDA
IDA: 通过直接分析推断
11742995 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KAT8 蛋白结构

Tudor-knot

Tudor-knot: RNA binding activity-knot of a chromodomain (55 - 110)

MOZ_SAS

MOZ_SAS: MOZ/SAS family (232 - 417)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 458 a.a.
蛋白主名 其他名称

histone acetyltransferase KAT8

K(lysine) acetyltransferase 8

KAT8 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra KAT8 Q9H7Z6 TP53 Homo sapiens P04637
Anti Tag CoIP
16601686
Intra KAT8 Q9H7Z6 KMT2A Homo sapiens Q03164
Anti Bait CoIP
15960975
Intra KAT8 Q9H7Z6 KMT2A Homo sapiens Q03164
Pull Down
15960975
Intra KAT8 Q9H7Z6 RNF2 Homo sapiens Q99496
Anti Bait CoIP
15960975
Cross KAT8 Q9H7Z6 HHF1 Saccharomyces cerevisiae P02309
Enzymatic Study
22020126
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Li-Ghorbani-Weisz-Hubshman Syndrome

LIGOWS

Li-Ghorgani-Weisz-Hubshman Syndrome
Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder
Koolen-De Vries Syndrome

KDVS

17q21.31 Microdeletion Syndrome

Microdeletion 17q21.31 Syndrome

Chromosome 17q21.31 Deletion Syndrome

Koolen De Vries Syndrome

Kansl1-Related Intellectual Disability Syndrome

Chromosome 17q21.31 Microdeletion Syndrome

Monosomy 17q21.31

17q21.31 Deletion Syndrome

Koolen Syndrome

Del(17)(Q21.31)
Capgras Syndrome

Capgras Delusion Theory
Haverhill Fever

Streptobacillosis

Streptobacillary Rat-Bite Fever

Streptobacillary Fever

Rat-Bite Fever Due To Streptobacillus Moniliformis

Erythema Arthriticum Epidemicum

Epidemic Arthritic Erythema
Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Medulloblastoma Predisposition Syndrome

Medulloblastoma, Somatic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Neuroectodermal Tumors, Primitive

Medulloblastomas

Desmoplastic Medulloblastoma

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-149302 MC4033 99.77% 否
HY-W015239 KAT8-IN-1 99.40% 否
HY-153604 MC4171 Inhibitor 98.68% 否
HY-RS07084 KAT8 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus KAT8 VGNC VGNC:63027
Rattus norvegicus KAT8 RGD RGD:1311512
Mus musculus KAT8 MGD MGI:1915023
Macaca mulatta KAT8 VGNC VGNC:99520
Bos taurus KAT8 VGNC VGNC:30404
Canis familiaris KAT8 VGNC VGNC:42215
Others KAT8 NCBI
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