2. Gene
  3. PCGF5 - polycomb group ring finger 5 Gene

PCGF5 - polycomb group ring finger 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Polycomb 组无名指 5

种属: Homo sapiens

同用名: RNF159

基因 ID: 84333 | 基因类型: protein coding

关于 PCGF5

Cytogenetic location: 10q23.32 Genomic coordinates (GRCh38): 10:91,156,219-91,284,337 (from NCBI)

This gene has 5 transcripts (splice variants), 211 orthologues and 7 paralogues. Ubiquitous expression in thyroid (RPKM 14.7), adrenal (RPKM 12.4) and 25 other tissues.

功能概要

预测可启用金属离子结合活性。在 RNA 聚合酶 II 的转录正调控上游或正调控内起作用。位于高尔基体；中心体；和核质。 PcG 蛋白复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable metal ion binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in Golgi apparatus; centrosome; and nucleoplasm. Part of PcG protein complex. [provided by Alliance of Genome Resources, Apr 2022]

PCGF5 基因产物(3)

mRNA Protein Name
NM_001256549.2 NP_001243478.1 polycomb group RING finger protein 5
NM_001257101.2 NP_001244030.1 polycomb group RING finger protein 5
NM_032373.5 NP_115749.2 polycomb group RING finger protein 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19273555 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
25519132 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of PcG protein complex IDA
IDA: 通过直接分析推断
21282530 GOA
located in nucleus IDA
IDA: 通过直接分析推断
21282530 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PCGF5 蛋白结构

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (18 - 56)

  • 0
  • 100
  • 200
  • 256 a.a.
蛋白主名 其他名称

polycomb group RING finger protein 5

RING finger protein 159

PCGF5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PCGF5 Q86SE9 BCOR Homo sapiens Q6W2J9-4
Y2H Array
25416956
Intra PCGF5 Q86SE9 BCOR Homo sapiens Q6W2J9-4
Y2H Prey Pooling
25416956
Cross PCGF5 Q86SE9 q2ghu2_ehrcr Ehrlichia chaffeensis Q2GHU2
Anti Tag CoIP
19273555
Cross PCGF5 Q86SE9 q2ghu2_ehrcr Ehrlichia chaffeensis Q2GHU2
Confocal
19273555
Intra PCGF5 Q86SE9 AUTS2 Homo sapiens Q8WXX7
Anti Tag CoIP
33961781
Intra PCGF5 Q86SE9 AUTS2 Homo sapiens Q8WXX7
TAP
27705803
Intra PCGF5 Q86SE9 AUTS2 Homo sapiens Q8WXX7
Anti Tag CoIP
28514442
Intra PCGF5 Q86SE9 AUTS2 Homo sapiens Q8WXX7
Anti Tag CoIP
25519132
Intra PCGF5 Q86SE9 TRAF2 Homo sapiens Q12933
Validated Y2H
25416956
Intra PCGF5 Q86SE9 TRAF2 Homo sapiens Q12933
Y2H Array
25416956
Intra PCGF5 Q86SE9 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
25416956
Intra PCGF5 Q86SE9 CBX8 Homo sapiens Q9HC52
Pull Down
21282530
Intra PCGF5 Q86SE9 PHC2 Homo sapiens Q8IXK0
Validated Y2H
25416956
Intra PCGF5 Q86SE9 RNF2 Homo sapiens Q99496
Anti Tag CoIP
33961781
Intra PCGF5 Q86SE9 RNF2 Homo sapiens Q99496
Anti Tag CoIP
25519132
Intra PCGF5 Q86SE9 RNF2 Homo sapiens Q99496
Anti Tag CoIP
22493164
Intra PCGF5 Q86SE9 RNF2 Homo sapiens Q99496
TAP
27705803
Intra PCGF5 Q86SE9 RNF2 Homo sapiens Q99496
Y2H Array
22493164
Intra PCGF5 Q86SE9 RNF2 Homo sapiens Q99496
Anti Tag CoIP
28514442
Intra PCGF5 Q86SE9 RING1 Homo sapiens Q06587
Anti Tag CoIP
22493164
Intra PCGF5 Q86SE9 RING1 Homo sapiens Q06587
TAP
27705803
Intra PCGF5 Q86SE9 RING1 Homo sapiens Q06587
Anti Tag CoIP
33961781
Intra PCGF5 Q86SE9 RING1 Homo sapiens Q06587
Y2H Array
22493164
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Bainbridge-Ropers Syndrome

BRPS

Severe Feeding Difficulties-Failure To Thrive-Microcephaly Due To Asxl3 Deficiency Syndrome

Asxl3-Related Disorder
Ehrlichiosis

Human Ehrlichiosis

He

Hey
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10148 PCGF5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PCGF5 VGNC VGNC:44303
Macaca mulatta PCGF5 VGNC VGNC:106085
Rattus norvegicus PCGF5 RGD RGD:1583513
Mus musculus PCGF5 MGD MGI:1923505
Bos taurus PCGF5 VGNC VGNC:32628
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