2. Gene
  3. CSNK2B - casein kinase 2 beta Gene

CSNK2B - casein kinase 2 beta Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：酪蛋白激酶 2 β

种属: Homo sapiens

同用名: G5A; CK2B; CK2N; Ckb1; Ckb2; CSK2B; POBINDS

基因 ID: 1460 | 基因类型: protein coding

关于 CSNK2B

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,666,080-31,670,067 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 262 orthologues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 91.5), skin (RPKM 69.4) and 25 other tissues.

功能概要

该基因编码酪蛋白激酶 II 的 β 亚基，酪蛋白激酶 II 是一种普遍存在的蛋白激酶，可调节代谢途径、信号转导、转录、翻译和复制。该酶由三个亚基 alpha、alpha prime 和 beta 组成，它们形成四聚体全酶。 alpha 和 alpha prime 亚基具有催化作用，而 beta 亚基具有调节功能。该酶定位于内质网和高尔基体。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2013 年 9 月]

This gene encodes the beta subunit of Casein Kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The Enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The Enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

CSNK2B 基因产物(2)

mRNA Protein Name
NM_001282385.2 NP_001269314.1 casein kinase II subunit beta isoform 2
NM_001320.7 NP_001311.3 casein kinase II subunit beta isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
19324893 GOA
enables chromatin binding IDA
IDA: 通过直接分析推断
25519132 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
10094392 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10094392 GOA
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
11984006 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
15723517 GOA
enables protein-macromolecule adaptor activity IDA
IDA: 通过直接分析推断
31341047 GOA
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
19233263 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adiponectin-activated signaling pathway IDA
IDA: 通过直接分析推断
19233263 GOA
involved in endothelial tube morphogenesis IMP
IMP: 通过突变表型推断
19592636 GOA
involved in negative regulation of blood vessel endothelial cell migration IDA
IDA: 通过直接分析推断
19592636 GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
28031292 GOA
involved in negative regulation of viral life cycle IDA
IDA: 通过直接分析推断
31341047 GOA
involved in peptidyl-threonine phosphorylation IDA
IDA: 通过直接分析推断
15723517 GOA
involved in positive regulation of SMAD protein signal transduction IDA
IDA: 通过直接分析推断
19592636 GOA
involved in positive regulation of activin receptor signaling pathway IMP
IMP: 通过突变表型推断
19592636 GOA
involved in symbiont-mediated disruption of host cell PML body IDA
IDA: 通过直接分析推断
20719947 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in PML body IDA
IDA: 通过直接分析推断
20719947 GOA
part of PcG protein complex IDA
IDA: 通过直接分析推断
21282530 GOA
located in chromatin IDA
IDA: 通过直接分析推断
31341047 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
19233263 GOA
located in nucleus IDA
IDA: 通过直接分析推断
21282530 GOA
colocalizes with plasma membrane IDA
IDA: 通过直接分析推断
19233263 GOA
part of protein kinase CK2 complex IDA
IDA: 通过直接分析推断
15723517 GOA
part of protein kinase CK2 complex IPI
IPI: 通过物理相互作用推断
22506723 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CSNK2B 蛋白结构

CK_II_beta

CK_II_beta: Casein kinase II regulatory subunit (8 - 191)

  • 0
  • 100
  • 200
  • 215 a.a.
蛋白主名 其他名称

casein kinase II subunit beta

CK II beta

CSNK2B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CSNK2B P67870 RPS6KA3 Homo sapiens P51812
Anti Tag CoIP
33961781
种属内
CSNK2B P67870 CST1 Homo sapiens P01037
Y2H Array
32296183
种属内
CSNK2B P67870 CST1 Homo sapiens P01037
Y2H Prey Pooling
32296183
种属内
CSNK2B P67870 TWF1 Homo sapiens Q12792
Validated Y2H
32296183
种属内
CSNK2B P67870 TWF1 Homo sapiens Q12792
Y2H Array
32296183
种属内
CSNK2B P67870 TWF1 Homo sapiens Q12792
Y2H Prey Pooling
32296183
种属内
CSNK2B P67870 BANP Homo sapiens Q8N9N5-2
Validated Y2H
32296183
种属内
CSNK2B P67870 ZNF410 Homo sapiens Q86VK4-3
Validated Y2H
32296183
种属内
CSNK2B P67870 NRF1 Homo sapiens Q16656-4
Validated Y2H
32296183
种属内
CSNK2B P67870 TFAP2D Homo sapiens Q7Z6R9
Validated Y2H
32296183
种属内
CSNK2B P67870 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32296183
种属间
CSNK2B P67870 Cry1 Mus musculus P97784
Y2H
23555304
种属间
CSNK2B P67870 Cry1 Mus musculus P97784
Pull Down
26562092
种属内
CSNK2B P67870 FAM86C1P Homo sapiens Q9NVL1-2
Y2H Prey Pooling
32296183
种属内
CSNK2B P67870 FAM86C1P Homo sapiens Q9NVL1-2
Validated Y2H
32296183
种属内
CSNK2B P67870 FAM86C1P Homo sapiens Q9NVL1-2
Y2H Array
32296183
种属内
CSNK2B P67870 ZNF19 Homo sapiens P17023
Y2H Prey Pooling
32296183
种属内
CSNK2B P67870 ZNF19 Homo sapiens P17023
Y2H Array
32296183
种属内
CSNK2B P67870 RPS6KA2 Homo sapiens Q15349
Anti Tag CoIP
33961781
种属内
CSNK2B P67870 MGC50722 Homo sapiens Q8IVT4
Validated Y2H
32296183
种属内
CSNK2B P67870 PTTG2 Homo sapiens Q9NZH5-2
Validated Y2H
32296183
种属内
CSNK2B P67870 PTTG2 Homo sapiens Q9NZH5-2
Y2H Array
32296183
种属内
CSNK2B P67870 PTTG2 Homo sapiens Q9NZH5-2
Y2H Prey Pooling
32296183
种属内
CSNK2B P67870 SIRT1 Homo sapiens Q96EB6
Anti Bait CoIP
21968188
种属内
CSNK2B P67870 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
32296183
种属内
CSNK2B P67870 TRIM54 Homo sapiens Q9BYV2
Y2H Array
32296183
种属内
CSNK2B P67870 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
32296183
种属内
CSNK2B P67870 PACS1 Homo sapiens Q6VY07
Pull Down
16977309
种属内
CSNK2B P67870 PIMREG Homo sapiens Q9BSJ6
Y2H Array
32296183
种属内
CSNK2B P67870 PIMREG Homo sapiens Q9BSJ6
Validated Y2H
32296183
种属内
CSNK2B P67870 PIMREG Homo sapiens Q9BSJ6
Y2H Prey Pooling
32296183
种属内
CSNK2B P67870 CSNK2A2 Homo sapiens P19784
Y2H
19011756
种属内
CSNK2B P67870 CSNK2A2 Homo sapiens P19784
Anti Tag CoIP
33961781
种属内
CSNK2B P67870 CSNK2A2 Homo sapiens P19784
Y2H
23555304
种属内
CSNK2B P67870 CSNK2A2 Homo sapiens P19784
Y2H
14667819
种属内
CSNK2B P67870 CSNK2A2 Homo sapiens P19784
Y2H
10094392
种属内
CSNK2B P67870 CSNK2A2 Homo sapiens P19784
Anti Tag CoIP
35271311
种属内
CSNK2B P67870 CSNK2A1 Homo sapiens P68400
Pull Down
21282530
种属内
CSNK2B P67870 CSNK2A1 Homo sapiens P68400
Y2H
19011756
种属内
CSNK2B P67870 CSNK2A1 Homo sapiens P68400
Y2H
21988832
种属内
CSNK2B P67870 CSNK2A1 Homo sapiens P68400
BRET
29997244
种属内
CSNK2B P67870 CSNK2A1 Homo sapiens P68400
Y2H
23555304
种属内
CSNK2B P67870 CSNK2A1 Homo sapiens P68400
Y2H
14667819
种属内
CSNK2B P67870 CSNK2A1 Homo sapiens P68400
Protein Kinase Assay
12769847
种属内
CSNK2B P67870 CSNK2A1 Homo sapiens P68400
Anti Bait CoIP
21968188
种属内
CSNK2B P67870 PHRF1 Homo sapiens Q9P1Y6
Anti Tag CoIP
33961781
种属内
CSNK2B P67870 RBM39 Homo sapiens Q14498
Validated Y2H
32296183
种属内
CSNK2B P67870 INO80B Homo sapiens Q9C086
Validated Y2H
32296183
种属内
CSNK2B P67870 RNF2 Homo sapiens Q99496
Anti Tag CoIP
35271311
种属内
CSNK2B P67870 RNF2 Homo sapiens Q99496
Pull Down
21282530
种属内
CSNK2B P67870 RNF2 Homo sapiens Q99496
Anti Tag CoIP
33961781
种属内
CSNK2B P67870 GLIS2 Homo sapiens Q9BZE0
Validated Y2H
32296183
种属内
CSNK2B P67870 RPS6KA5 Homo sapiens O75582
Anti Tag CoIP
33961781
种属内
CSNK2B P67870 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
种属内
CSNK2B P67870 SELI Homo sapiens Q8WU57
Validated Y2H
32296183
种属内
CSNK2B P67870 SELI Homo sapiens Q8WU57
Y2H Prey Pooling
32296183
种属内
CSNK2B P67870 SELI Homo sapiens Q8WU57
Y2H Array
32296183
种属间
CSNK2B P67870 Clock Mus musculus O08785
Y2H
23555304
种属间
CSNK2B P67870 Clock Mus musculus O08785
Anti Tag CoIP
23555304
种属内
CSNK2B P67870 NGDN Homo sapiens Q8NEJ9
Y2H Prey Pooling
32296183
种属内
CSNK2B P67870 NGDN Homo sapiens Q8NEJ9
Validated Y2H
32296183
种属内
CSNK2B P67870 NGDN Homo sapiens Q8NEJ9
Y2H Array
32296183
种属间
CSNK2B P67870 Clip1 Rattus norvegicus Q9JK25
Anti Bait CoIP
20664522
种属间: 跨种属相互作用 种属内: 同种属相互作用

CSNK2B 抗体

目录号 产品名 应用 反应物种
HY-P80586 Casein Kinase 2 beta Antibody WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat

关联疾病

疾病名称 别名
Poirier-Bienvenu Neurodevelopmental Syndrome

POBINDS
Prognathism, Mandibular

Habsburg Jaw

'Habsburg Jaw'

'Hapsburg Jaw'

Prognathism Mandibular

Hapsburg Jaw

Autosomal Dominant Prognathism
Filippi Syndrome

Scott Craniodigital Syndrome With Mental Retardation

Type 1 Syndactyly-Microcephaly-Intellectual Disability Syndrome

FLPIS

Scott Bryant Graham Syndrome

Craniodigital-Intellectual Disability Syndrome

Scott Craniodigital Syndrome

Scott-Bryant-Graham Syndrome

Syndactyly, Type I, With Microcephaly And Mental Retardation

Syndactyly Type I With Microcephaly And Intellectual Disability

Unusual Facial Appearance, Microcephaly, Growth And Intellectual Disability And Syndactyly

Craniodigital Syndrome With Intellectual Disability

Craniodigital Syndrome-Intellectual Disability Syndrome

Craniodigital Syndrome-Intellectual Disability, Scott Type

Intellectual Disability-Craniodigital Syndrome
Autosomal Dominant Non-Syndromic Intellectual Disability
Enophthalmos
Chromosome 2q35 Duplication Syndrome

Syndactyly

Syndactyly Type 1

Sdty1

Zygodactyly

Syndactyly, Type I

Sd1

Syndactyly, Type 1, With Or Without Craniosynostosis

Symphalangism

Non-Syndromic Syndactyly

Symphalangy

Webbing Of Digits

Syndactyly, Type 1
Egg Allergy

Allergy To Eggs

Allergies Egg

Egg Hypersensitivity
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03253 CSNK2B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CSNK2B MGD MGI:88548
Bos taurus CSNK2B VGNC VGNC:53965
Rattus norvegicus CSNK2B RGD RGD:619978
Felis catus CSNK2B VGNC VGNC:102410
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