RPS6KA3 - ribosomal protein S6 kinase A3 Gene

中文名称：核糖体蛋白 S6 激酶 A3

种属: Homo sapiens

同用名: CLS; RSK; HU-3; RSK2; MRX19; ISPK-1; XLID19; p90-RSK2; pp90RSK2; MAPKAPK1B; S6K-alpha3

基因 ID: 6197 | 基因类型: protein coding

关于 RPS6KA3

Cytogenetic location: Xp22.12 Genomic coordinates (GRCh38): X:20,149,911-20,267,097 (from NCBI)

This gene has 16 transcripts (splice variants), 252 orthologues, 7 paralogues and is associated with 8 phenotypes. Ubiquitous expression in appendix (RPKM 16.2), colon (RPKM 16.0) and 25 other tissues.

功能概要

该基因编码丝氨酸/苏氨酸激酶 RSK (核糖体 S6 激酶) 家族的成员。该激酶包含 2 个不同的激酶催化结构域并磷酸化各种底物，包括有丝分裂原活化激酶 (MAPK) 信号通路的成员。这种蛋白质的活性与控制细胞生长和分化有关。该基因的突变与 Coffin-Lowry 综合征 (CLS) 有关。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008]

RPS6KA3 基因产物(17)

mRNA	Protein	Name
XM_011545555.2	XP_011543857.1	ribosomal protein S6 kinase alpha-3 isoform X1
XM_017029718.3	XP_016885207.1	ribosomal protein S6 kinase alpha-3 isoform X10
XM_005274577.4	XP_005274634.1	ribosomal protein S6 kinase alpha-3 isoform X12
XM_047442334.1	XP_047298290.1	ribosomal protein S6 kinase alpha-3 isoform X8
XM_017029717.3	XP_016885206.1	ribosomal protein S6 kinase alpha-3 isoform X8
NM_004586.3	NP_004577.1	ribosomal protein S6 kinase alpha-3
XM_011545561.3	XP_011543863.1	ribosomal protein S6 kinase alpha-3 isoform X6
XM_017029719.3	XP_016885208.1	ribosomal protein S6 kinase alpha-3 isoform X11
XM_047442332.1	XP_047298288.1	ribosomal protein S6 kinase alpha-3 isoform X3
XM_011545557.3	XP_011543859.1	ribosomal protein S6 kinase alpha-3 isoform X6
XM_011545560.2	XP_011543862.1	ribosomal protein S6 kinase alpha-3 isoform X6
XM_005274573.3	XP_005274630.1	ribosomal protein S6 kinase alpha-3 isoform X4
XM_047442336.1	XP_047298292.1	ribosomal protein S6 kinase alpha-3 isoform X11
XM_011545562.3	XP_011543864.1	ribosomal protein S6 kinase alpha-3 isoform X7
XM_011545556.2	XP_011543858.1	ribosomal protein S6 kinase alpha-3 isoform X2
XM_047442333.1	XP_047298289.1	ribosomal protein S6 kinase alpha-3 isoform X5
XM_047442335.1	XP_047298291.1	ribosomal protein S6 kinase alpha-3 isoform X9

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IDA IDA: 通过直接分析推断	18402937	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10094392	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of apoptotic process	IDA IDA: 通过直接分析推断	18402937	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	22065586	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPS6KA3 蛋白结构

Pkinase

Pkinase_C

Pkinase

0
200
400
600
740 a.a.

蛋白主名

其他名称

ribosomal protein S6 kinase alpha-3

MAP kinase-activated protein kinase 1b	MAPK-activated protein kinase 1b
MAPKAP kinase 1b	MAPKAPK-1b
RSK-2	S6K-alpha-3
epididymis secretory sperm binding protein	insulin-stimulated protein kinase 1
p90-RSK 3	ribosomal S6 kinase 2
ribosomal protein S6 kinase, 90kDa, polypeptide 3

RPS6KA3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RPS6KA3	P51812	CSNK2B	Homo sapiens	P67870	Pull Down	32707033
种属内	RPS6KA3	P51812	CSNK2B	Homo sapiens	P67870	Anti Tag CoIP	35271311
种属内	RPS6KA3	P51812	CSNK2B	Homo sapiens	P67870	Anti Tag CoIP	31980649
种属内	RPS6KA3	P51812	CSNK2B	Homo sapiens	P67870	Y2H	10094392
种属内	RPS6KA3	P51812	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	31980649
种属内	RPS6KA3	P51812	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
种属内	RPS6KA3	P51812	MAPK1	Homo sapiens	P28482	Pull Down	32707033
种属内	RPS6KA3	P51812	MAPK1	Homo sapiens	P28482	PLA	25241761
种属内	RPS6KA3	P51812	MAPK1	Homo sapiens	P28482	Y2H	21988832
种属间	RPS6KA3	P51812	yopM	Yersinia enterocolitica serotype O:8/biotype 1B	A1JU68	Anti Bait CoIP	25513777

种属间: 跨种属相互作用 种属内: 同种属相互作用

RPS6KA3 抗体

目录号	产品名	应用	反应物种
HY-P80850	Phospho-RSK2 (Ser227) Antibody	WB, IP	Human, Mouse, Rat

关联疾病

疾病名称

别名

Intellectual Developmental Disorder, X-Linked 19

XLID19	Mrx19
Mrx31

Chromosome 16p13.3 Deletion Syndrome, Proximal

Rubinstein-Taybi Syndrome	Broad Thumb-Hallux Syndrome
Chromosome 16p13.3 Deletion Syndrome	Rubinstein-Taybi Syndrome Due To 16p13.3 Microdeletion
Rubinstein Syndrome	Broad Thumbs-Halluces Syndrome
Rsts	Rubinstein-Taybi Deletion Syndrome
Rsts Deletion Syndrome	Proximal Chromosome 16p13.3 Deletion Syndrome
16p13.3 Deletion Syndrome	Broad Thumbs And Great Toes, Characteristic Facies, And Mental Retardation
Rts

Hypertelorism

Eyes Wide Apart	Eyes Widely Set
Hypertelorism Of Orbit	Ocular Hypertelorism
Orbital Separation Excessive

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

Ventricular Septal Defect

Ventricular Septal Defects	Interventricular Septal Defect
Heart Septal Defects, Ventricular	Ventricular Septal Abnormality
Interventricular Septum Defect	Ventricular Septum Defect
Vsd - [Ventricular Septum Defect]	Congenital Ventricular Septal Defect
Single Ventricular Septal Defect

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability	Non-Specific X-Linked Mental Retardation
X-Linked Non-Specific Intellectual Disability

Symptomatic Form Of Coffin-Lowry Syndrome In Female Carriers

Non-Syndromic X-Linked Intellectual Disability 73

Mrx73

X-Linked Mental Retardation 73

Coffin-Lowry Syndrome

CLS	Mental Retardation With Osteocartilaginous Abnormalities
Coffin Syndrome 1	Coffin Syndrome
Dwarfism, Lean Spastic Type	Lean Spastic Dwarfism
Coffin Lowry Syndrome

Non-Syndromic X-Linked Intellectual Disability 19

Mrx19

Orthostatic Intolerance

Mitral Valve Prolapse	Neurocirculatory Asthenia
Mitral Valve Prolapse Syndrome	Irritable Heart
Systolic Click-Murmur Syndrome	Soldiers Heart
Cardiovascular Malfunction Arising From Mental Factors	Cardiovascular Neurosis
Da Costa'S Syndrome	Krishaber'S Disease
Barlow'S Syndrome	Floppy Mitral Valve
Mitral Leaflet Syndrome	Myxomatous Mitral Valve Prolapse
Postural Orthostatic Tachycardia Syndrome Due To Net Deficiency	Familial Orthostatic Tachycardia Due To Norepinephrine Transporter Deficiency
Orthostatic Intolerance Due To Net Deficiency	Pots Due To Net Deficiency
OI	Intolerance, Orthostatic
Mitral Valve Prolapse, Familial, X-Linked	Ballooning Mitral Valve
Barlow Syndrome	Flail Mitral Leaflet
Myxomatous Mitral Valve	Mitral Valve Prolapse-Click Syndrome
Prolapsing Mitral Valve Leaflet Syndrome	Billowing Mitral Valve Leaflet
Posterior Mitral Leaflet Deformity	Ballooning Posterior Leaflet Syndrome
Blue Valve Syndrome	Floppy Mitral Valve Syndrome
Mitral Valvular Prolapse	Systolic Click Syndrome

Hypotonia

Specific Learning Disability

Specific Learning Difficulty

Specific Learning Disorder

Hemochromatosis, Type 1

Hemochromatosis	Hemochromatosis Type 1
Hereditary Hemochromatosis	Hh
HFE1	Hfe Hemochromatosis, Modifier Of
Symptomatic Form Of Classic Hemochromatosis	Symptomatic Form Of Hemochromatosis Type 1
Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis	Haemochromatosis
Iron Storage Disorder	Bronze Diabetes
Hlah	Hfe
Hemochromatosis, Hereditary	Diabetes Bronze
Classic Hemochromatosis	Hfe-Associated Hereditary Hemochromatosis
Hemochromatosis Classic	Bronzed Cirrhosis
Familial Hemochromatosis	Genetic Hemochromatosis
Hc	Hereditary Haemochromatosis
Pigmentary Cirrhosis	Primary Hemochromatosis
Troisier-Hanot-Chauffard Syndrome	Von Recklenhausen-Applebaum Disease
Hemochromatosis 1	Primary Hereditary Hemochromatosis
Bronze Cirrhosis

Gastroesophageal Reflux

Gastroesophageal Reflux Disease	Gerd
GER	Gastroesophageal Reflux, Pediatric
Acid Reflux	Gastresophageal Reflux
Gastro-Esophageal Reflux	Gerd - Gastro-Esophageal Reflux Disease

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-148063	DB0614		98.80%	否
HY-148061	DB1113		99.28%	否
HY-150643	RSK2-IN-2	Inhibitor	/	否
HY-150717	RSK2-IN-3	Inhibitor	/	否
HY-RS12254	RPS6KA3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS12255	Rps6ka3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS12256	Rps6ka3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	RPS6KA3	RGD	RGD:1563860
Mus musculus	RPS6KA3	MGD	MGI:104557
Canis familiaris	RPS6KA3	VGNC	VGNC:45740
Bos taurus	RPS6KA3	VGNC	VGNC:34142
Macaca mulatta	RPS6KA3	VGNC	VGNC:76929
Felis catus	RPS6KA3	VGNC	VGNC:64756
Others	RPS6KA3	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RPS6KA3 - ribosomal protein S6 kinase A3 Gene

关于 RPS6KA3

功能概要

RPS6KA3 基因产物(17)

RPS6KA3 蛋白结构

RPS6KA3 蛋白互作信息

RPS6KA3 抗体

关联疾病

直系同源

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RPS6KA3 - ribosomal protein S6 kinase A3 Gene

关于 RPS6KA3

功能概要

RPS6KA3 基因产物(17)

RPS6KA3 蛋白结构

RPS6KA3 蛋白互作信息

RPS6KA3 抗体

关联疾病

相关产品

直系同源

热门区域

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