2. Gene
  3. RPS6KA5 - ribosomal protein S6 kinase A5 Gene

RPS6KA5 - ribosomal protein S6 kinase A5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核糖体蛋白 S6 激酶 A5

种属: Homo sapiens

同用名: MSK1; RLPK; MSPK1

基因 ID: 9252 | 基因类型: protein coding

关于 RPS6KA5

Cytogenetic location: 14q32.11 Genomic coordinates (GRCh38): 14:90,847,861-91,060,641 (from NCBI)

This gene has 8 transcripts (splice variants), 221 orthologues and 7 paralogues. Ubiquitous expression in brain (RPKM 2.4), endometrium (RPKM 2.3) and 25 other tissues.

功能概要

启用 ATP 结合活性和蛋白丝氨酸/苏氨酸激酶活性。参与多个过程，包括组蛋白-丝氨酸磷酸化；组蛋白修饰的正调控；和转录调控，DNA 模板化。位于细胞质和核质中。 [由基因组资源联盟提供，2022 年 4 月]

Enables ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including histone-serine phosphorylation; positive regulation of histone modification; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RPS6KA5 基因产物(14)

mRNA Protein Name
NM_001322227.2 NP_001309156.1 ribosomal protein S6 kinase alpha-5 isoform c
NM_001322228.2 NP_001309157.1 ribosomal protein S6 kinase alpha-5 isoform d
NM_001322229.2 NP_001309158.1 ribosomal protein S6 kinase alpha-5 isoform e
NM_001322230.2 NP_001309159.1 ribosomal protein S6 kinase alpha-5 isoform f
NM_001322231.2 NP_001309160.1 ribosomal protein S6 kinase alpha-5 isoform g
NM_001322232.2 NP_001309161.1 ribosomal protein S6 kinase alpha-5 isoform h
NM_001322233.2 NP_001309162.1 ribosomal protein S6 kinase alpha-5 isoform i
NM_001322234.2 NP_001309163.1 ribosomal protein S6 kinase alpha-5 isoform j
NM_001322235.2 NP_001309164.1 ribosomal protein S6 kinase alpha-5 isoform k
NM_001322236.2 NP_001309165.1 ribosomal protein S6 kinase alpha-5 isoform l
NM_001322237.2 NP_001309166.1 ribosomal protein S6 kinase alpha-5 isoform k
NM_001322238.2 NP_001309167.1 ribosomal protein S6 kinase alpha-5 isoform m
NM_004755.4 NP_004746.2 ribosomal protein S6 kinase alpha-5 isoform a
NM_182398.3 NP_872198.1 ribosomal protein S6 kinase alpha-5 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
9687510 GOA
enables histone H2AS1 kinase activity IDA
IDA: 通过直接分析推断
15010469 GOA
enables histone H3S10 kinase activity IMP
IMP: 通过突变表型推断
12773393 GOA
enables histone H3S28 kinase activity IMP
IMP: 通过突变表型推断
12773393 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20936779 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
9687510 GOA
enables protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
9873047 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in interleukin-1-mediated signaling pathway IMP
IMP: 通过突变表型推断
20018936 GOA
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
9687510 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
15010469 GOA
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
12628924 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
20018936 GOA
involved in post-translational protein modification IDA
IDA: 通过直接分析推断
15010469 GOA
involved in post-translational protein modification IMP
IMP: 通过突变表型推断
12773393 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
9687510 GOA
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
9687510 GOA
involved in regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
12763138 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
18511904 GOA
located in nucleus IDA
IDA: 通过直接分析推断
9687510 GOA
located in nucleus IMP
IMP: 通过突变表型推断
12628924 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPS6KA5 蛋白结构

Pkinase

Pkinase: Protein kinase domain (49 - 318)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (340 - 381)

Pkinase

Pkinase: Protein kinase domain (429 - 686)

  • 0
  • 200
  • 400
  • 600
  • 802 a.a.
蛋白主名 其他名称

ribosomal protein S6 kinase alpha-5

90 kDa ribosomal protein S6 kinase 5

RPS6KA5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RPS6KA5 O75582 CTNNA3 Homo sapiens Q9UI47-2
Validated Y2H
32296183
种属内
RPS6KA5 O75582 CSNK2B Homo sapiens P67870
Y2H
21988832
种属内
RPS6KA5 O75582 CSNK2B Homo sapiens P67870
Pull Down
32707033
种属内
RPS6KA5 O75582 MAP3K20 Homo sapiens Q9NYL2
Pull Down
21988832
种属内
RPS6KA5 O75582 MAP3K20 Homo sapiens Q9NYL2
Confocal
21988832
种属内
RPS6KA5 O75582 MAPK14 Homo sapiens Q16539
Y2H Pooling
20936779
种属间: 跨种属相互作用 种属内: 同种属相互作用

RPS6KA5 抗体

目录号 产品名 应用 反应物种
HY-P80835 Phospho-MSK1 (Ser360) Antibody WB, ICC/IF, IP Human, Mouse, Rat, Hamster
HY-P80836 Phospho-MSK1 (Ser376) Antibody WB, IHC-P, IP Human, Rat

关联疾病

疾病名称 别名
Joubert Syndrome 28

JBTS28
Coffin-Lowry Syndrome

CLS

Coffin Syndrome 1

Coffin Syndrome

Intellectual Disability With Osteocartilaginous Abnormalities

Dwarfism, Lean Spastic Type

Lean Spastic Dwarfism

Mental Retardation With Osteocartilaginous Abnormalities

Coffin Lowry Syndrome
Bladder Cancer

Urinary Bladder Cancer

Bladder Carcinoma

Urinary Bladder Carcinoma

Bladder Neoplasm

Bladder Tumor

Cancer, Bladder

Malignant Neoplasm Of Urinary Bladder

Carcinoma Of Bladder

Bladder Cancer, Somatic

Tumor Of The Bladder

Carcinoma Of Urinary Bladder

Bladder Carcinoma Urinary

Cancer Of The Urinary Bladder

Cancer, Urinary Bladder

Malignant Bladder Neoplasm

Malignant Bladder Tumor

Neoplasm Of The Bladder

Neoplasm Of The Urinary Bladder

Tumor Of The Urinary Bladder

Urinary Bladder Neoplasm

BLC

Urothelial Carcinoma Of The Bladder

Bladder Tumors

Urinary Bladder Neoplasms

Bladder Cancer Nos

Vesical Cancer Nos

Malignant Neoplasm Of Bladder, Part Unspecified

Malignant Tumour Of Urinary Bladder

Primary Malignant Neoplasm Of Bladder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12258 RPS6KA5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus RPS6KA5 MGD MGI:1920336
Bos taurus RPS6KA5 VGNC VGNC:34144
Rattus norvegicus RPS6KA5 RGD RGD:1308336
Felis catus RPS6KA5 VGNC VGNC:64758
Canis familiaris RPS6KA5 VGNC VGNC:45742
Macaca mulatta RPS6KA5 VGNC VGNC:76931
Others RPS6KA5 NCBI
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