CBX4 - chromobox 4 Gene

中文名称：色盒 4

种属: Homo sapiens

同用名: PC2; NBP16

基因 ID: 8535 | 基因类型: protein coding

关于 CBX4

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:79,833,156-79,839,440 (from NCBI)

This gene has 4 transcripts (splice variants), 268 orthologues and 8 paralogues. Broad expression in bone marrow (RPKM 17.4), spleen (RPKM 5.9) and 24 other tissues.

功能概要

启用 SUMO 绑定活动；相扑连接酶活性；和酶结合活性。参与 RNA 聚合酶 II 对转录的负调控。位于核体。 PRC1 复合体的一部分。与肝细胞癌有关。肝细胞癌的生物标志物。 [由基因组资源联盟提供，2022 年 4 月]

Enables SUMO binding activity; SUMO Ligase activity; and Enzyme binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nuclear body. Part of PRC1 complex. Implicated in hepatocellular carcinoma. Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Apr 2022]

CBX4 基因产物(1)

mRNA	Protein	Name
NM_003655.3	NP_003646.2	E3 SUMO-protein ligase CBX4

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables SUMO binding	IDA IDA: 通过直接分析推断	20176810	GOA
enables SUMO ligase activity	IDA IDA: 通过直接分析推断	27068747	GOA
enables SUMO transferase activity	EXP EXP: 通过实验结果推断	12679040	GOA
enables enzyme binding	IPI IPI: 通过物理相互作用推断	17087506	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16169070	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	18567530	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	21282530	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of PRC1 complex	IDA IDA: 通过直接分析推断	12167701	GOA
part of PcG protein complex	IDA IDA: 通过直接分析推断	21282530	GOA
located in nucleus	IDA IDA: 通过直接分析推断	9367786	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CBX4 蛋白结构

Chromo

0
100
200
300
400
500
560 a.a.

蛋白主名

其他名称

E3 SUMO-protein ligase CBX4

NS5ATP1-binding protein 16

CBX4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	CBX4	O00257	BMI1	Homo sapiens	P35226	Anti Tag CoIP	26496610
Intra	CBX4	O00257	BMI1	Homo sapiens	P35226	TAP	27705803
Intra	CBX4	O00257	BMI1	Homo sapiens	P35226	Anti Bait CoIP	22078878
Intra	CBX4	O00257	YWHAB	Homo sapiens	P31946	Anti Bait CoIP	22078878
Intra	CBX4	O00257	HIF1A	Homo sapiens	Q16665	Anti Tag CoIP	24434214
Intra	CBX4	O00257	HIF1A	Homo sapiens	Q16665	CH-IP	24434214
Intra	CBX4	O00257	HIF1A	Homo sapiens	Q16665	Pull Down	24434214
Intra	CBX4	O00257	CBX8	Homo sapiens	Q9HC52	Anti Bait CoIP	17332741
Intra	CBX4	O00257	CBX8	Homo sapiens	Q9HC52	Anti Tag CoIP	26496610
Intra	CBX4	O00257	RNF2	Homo sapiens	Q99496	TAP	27705803
Intra	CBX4	O00257	RNF2	Homo sapiens	Q99496	Anti Tag CoIP	26496610
Intra	CBX4	O00257	SUMO1	Homo sapiens	P63165	Confocal	20098713
Intra	CBX4	O00257	SUMO1	Homo sapiens	P63165	Pull Down	20098713
Intra	CBX4	O00257	CTBP1	Homo sapiens	Q13363	Anti Tag CoIP	20098713
Intra	CBX4	O00257	CTBP1	Homo sapiens	Q13363	Confocal	20098713

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02011	CBX4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	CBX4	RGD	RGD:1587243
Canis familiaris	CBX4	VGNC	VGNC:54929
Macaca mulatta	CBX4	VGNC	VGNC:70558
Mus musculus	CBX4	MGD	MGI:1195985
Felis catus	CBX4	VGNC	VGNC:98768
Bos taurus	CBX4	VGNC	VGNC:55784

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CBX4 - chromobox 4 Gene

关于 CBX4

功能概要

CBX4 基因产物(1)

CBX4 蛋白结构

CBX4 蛋白互作信息

关联疾病

直系同源

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CBX4 - chromobox 4 Gene

关于 CBX4

功能概要

CBX4 基因产物(1)

CBX4 蛋白结构

CBX4 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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