1. Gene
  2. CTBP1 - C-terminal binding protein 1 Gene

CTBP1 - C-terminal binding protein 1 Gene

中文名称:C 端结合蛋白 1

种属: Homo sapiens

同用名: BARS; HADDTS

基因 ID: 1487 | 基因类型: protein coding

关于 CTBP1

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:1,211,445-1,250,355 (from NCBI)

This gene has 23 transcripts (splice variants), 228 orthologues, 3 paralogues and is associated with 4 phenotypes. Ubiquitous expression in spleen (RPKM 9.3), prostate (RPKM 7.1) and 25 other tissues.

功能概要

该基因编码的蛋白质可与腺病毒 E1A 蛋白的 C 末端结合。这种磷蛋白是一种转录抑制因子,可能在细胞增殖过程中发挥作用。这种蛋白质和第二个密切相关的基因 CTBP2 的产物可以二聚化。这两种蛋白质还可以与参与发育过程中基因表达调节的多梳组蛋白复合物相互作用。来自该基因的转录本的可变剪接导致多个转录本变体。[RefSeq 提供,2008 年 7 月]

This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

CTBP1 基因产物(10)

mRNA Protein Name
NM_001012614.2 NP_001012632.1 C-terminal-binding protein 1 isoform 2
NM_001328.3 NP_001319.1 C-terminal-binding protein 1 isoform 1
NM_001377186.1 NP_001364115.1 C-terminal-binding protein 1 isoform 3
NM_001377187.1 NP_001364116.1 C-terminal-binding protein 1 isoform 4
NM_001377188.1 NP_001364117.1 C-terminal-binding protein 1 isoform 4
NM_001377189.1 NP_001364118.1 C-terminal-binding protein 1 isoform 4
NM_001377190.1 NP_001364119.1 C-terminal-binding protein 1 isoform 4
NM_001377191.1 NP_001364120.1 C-terminal-binding protein 1 isoform 2
NM_001377192.1 NP_001364121.1 C-terminal-binding protein 1 isoform 2
NM_001377193.1 NP_001364122.1 C-terminal-binding protein 1 isoform 2

CTBP1 蛋白结构

2-Hacid_dh

2-Hacid_dh: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain (38 - 351)

2-Hacid_dh_C

2-Hacid_dh_C: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain (134 - 317)

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  • 440 a.a.
蛋白主名 其他名称

C-terminal-binding protein 1

brefeldin A-ribosylated substrate

CTBP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CTBP1 Q13363 THAP11 Homo sapiens Q96EK4
Anti Tag CoIP
21988832
种属内
CTBP1 Q13363 THAP11 Homo sapiens Q96EK4
Anti Tag CoIP
31041561
种属内
CTBP1 Q13363 HIC1 Homo sapiens Q14526
Anti Bait CoIP
16762039
种属内
CTBP1 Q13363 ZNF516 Homo sapiens Q92618
Anti Tag CoIP
33961781
种属内
CTBP1 Q13363 ZNF516 Homo sapiens Q92618
GMS
28947780
种属内
CTBP1 Q13363 ZNF516 Homo sapiens Q92618
Anti Tag CoIP
28514442
种属内
CTBP1 Q13363 ZNF516 Homo sapiens Q92618
Proximity Labelling
35016035
种属内
CTBP1 Q13363 ZNF516 Homo sapiens Q92618
Anti Tag CoIP
35271311
种属内
CTBP1 Q13363 ZNF516 Homo sapiens Q92618
Anti Tag CoIP
31041561
种属内
CTBP1 Q13363 ZNF366 Homo sapiens Q8N895
Pull Down
17085477
种属内
CTBP1 Q13363 ZNF366 Homo sapiens Q8N895
Anti Tag CoIP
17085477
种属内
CTBP1 Q13363 ZNF366 Homo sapiens Q8N895
Y2H
17085477
种属内
CTBP1 Q13363 ZBTB18 Homo sapiens Q99592
Anti Tag CoIP
33961781
种属内
CTBP1 Q13363 ZBTB18 Homo sapiens Q99592
Y2H Array
24722188
种属内
CTBP1 Q13363 HEMGN Homo sapiens Q9BXL5
Y2H Array
21988832
种属内
CTBP1 Q13363 LCORL Homo sapiens Q8N3X6
Anti Tag CoIP
33961781
种属内
CTBP1 Q13363 LCORL Homo sapiens Q8N3X6
Anti Tag CoIP
28514442
种属内
CTBP1 Q13363 LCORL Homo sapiens Q8N3X6
Anti Tag CoIP
31041561
种属内
CTBP1 Q13363 LCORL Homo sapiens Q8N3X6
Y2H
21900206
种属内
CTBP1 Q13363 LCORL Homo sapiens Q8N3X6
Proximity Labelling
35016035
种属内
CTBP1 Q13363 CBX4 Homo sapiens O00257
Anti Tag CoIP
33961781
种属内
CTBP1 Q13363 CBX4 Homo sapiens O00257
Anti Tag CoIP
28514442
种属内
CTBP1 Q13363 KLF4 Homo sapiens O43474
Anti Tag CoIP
19751731
种属内
CTBP1 Q13363 KLF4 Homo sapiens O43474
Anti Bait CoIP
19751731
种属内
CTBP1 Q13363 CTBP2 Homo sapiens P56545
Anti Tag CoIP
35016035
种属内
CTBP1 Q13363 CTBP2 Homo sapiens P56545
Anti Tag CoIP
33961781
种属内
CTBP1 Q13363 CTBP2 Homo sapiens P56545
GMS
28947780
种属内
CTBP1 Q13363 CTBP2 Homo sapiens P56545
Anti Tag CoIP
31041561
种属内
CTBP1 Q13363 CTBP2 Homo sapiens P56545
Anti Tag CoIP
26496610
种属内
CTBP1 Q13363 CTBP2 Homo sapiens P56545
Anti Tag CoIP
35271311
种属内
CTBP1 Q13363 CTBP2 Homo sapiens P56545
Proximity Labelling
35016035
种属内
CTBP1 Q13363 LCOR Homo sapiens Q96JN0
Y2H Array
20211142
种属内
CTBP1 Q13363 LCOR Homo sapiens Q96JN0
Anti Tag CoIP
33961781
种属内
CTBP1 Q13363 LCOR Homo sapiens Q96JN0
Anti Tag CoIP
28514442
种属内
CTBP1 Q13363 LCOR Homo sapiens Q96JN0
Proximity Labelling
35016035
种属内
CTBP1 Q13363 LCOR Homo sapiens Q96JN0
Anti Tag CoIP
31041561
种属内
CTBP1 Q13363 LCOR Homo sapiens Q96JN0
Anti Tag CoIP
35271311
种属内
CTBP1 Q13363 RAI2 Homo sapiens Q9Y5P3
Y2H Array
24722188
种属内
CTBP1 Q13363 RAI2 Homo sapiens Q9Y5P3
Proximity Labelling
35016035
种属内
CTBP1 Q13363 RAI2 Homo sapiens Q9Y5P3
Anti Tag CoIP
35016035
种属内
CTBP1 Q13363 NRIP1 Homo sapiens P48552
Proximity Labelling
35016035
种属内
CTBP1 Q13363 NRIP1 Homo sapiens P48552
Y2H Array
24722188
种属内
CTBP1 Q13363 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
种属内
CTBP1 Q13363 TERF2IP Homo sapiens Q9NYB0
BiFC
21044950
种属间: 跨种属相互作用 种属内: 同种属相互作用

CTBP1 抗体

目录号 产品名 应用 反应物种
HY-P82285 CTBP1 Antibody (YA2030) WB, IHC-P, ICC/IF, IP Human, Mouse, Rat

关联疾病

疾病名称 别名
Hypotonia, Ataxia, Developmental Delay, And Tooth Enamel Defect Syndrome

HADDTS

Chromosome 4p Deletion

4p Partial Monosomy Syndrome

Chromosome 4 Short Arm Deletion

4p Deletion

4p Monosomy

Deletion 4p

Monosomy 4p

Partial Monosomy 4p

Wolf-Hirschhorn Syndrome

Chromosome 4 Short Arm Deletion Syndrome

Deletion Of Short Arm Of Chromosome 4

Wolf-Hirschhorn Syndrome

Pitt-Rogers-Danks Syndrome

WHS

Chromosome 4p16.3 Deletion Syndrome

Wittwer Syndrome

4p- Syndrome

Pitt Syndrome

4p Deletion Syndrome

Distal Deletion 4p

Distal Monosomy 4p

Telomeric Deletion 4p

Prds

4p Syndrome

Chromosome 4p Syndrome

Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation

Wolf Syndrome

Chromosome 4p Deletion Syndrome

Chromosome 4p Monosomy

Del Syndrome

Monosomy 4p

Partial Monosomy 4p

Chromosome 4 Short Arm Deletion

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Hypotonia
Holoprosencephaly

Holoprosencephaly Sequence

Hpe

Hpe - [Holoprosencephaly]

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Mowat-Wilson Syndrome

MOWS

Microcephaly, Mental Retardation, And Distinct Facial Features, With Or Without Hirschsprung Disease

Hirschsprung Disease-Mental Retardation Syndrome

Mowat-Wilson Syndrome Due To Monosomy 2q22

Hirschsprung Disease Mental Retardation Syndrome

Microcephaly, Mental Retardation, And Distinct Facial Featrues, With Or Without Hirschprung Disease

Hirschsprung Disease - Intellectual Disability Syndrome

Hirschsprung Disease Intellectual Disability Syndrome

Intellectual Disability, Microcephaly, And Distinct Facial Features With Or Without Hirschsprung Disease

Mws

Hirschsprung Disease-Intellectual Disability Syndrome

Hirschsprung Disease And Intellectual Disability Due To 2q22 Microdeletion

Hirschsprung Disease And Intellectual Disability Due To Del(2)(Q22)

Hirschsprung Disease And Intellectual Disability Due To Monosomy 2q22

Mowat-Wilson Syndrome Due To 2q22 Microdeletion

Mowat-Wilson Syndrome Due To Del(2)Q(22)

Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation

Hirschsprung Disease And Intellectual Disability Due To A Zeb2 Point Mutation

Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CTBP1 RGD RGD:2441
Bos taurus CTBP1 VGNC VGNC:27785
Canis familiaris CTBP1 VGNC VGNC:39686
Macaca mulatta CTBP1 VGNC VGNC:71539
Mus musculus CTBP1 MGD MGI:1201685
Felis catus CTBP1 VGNC VGNC:61242