2. Gene
  3. HIC1 - HIC ZBTB transcriptional repressor 1 Gene

HIC1 - HIC ZBTB transcriptional repressor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：HIC ZBTB 转录抑制因子 1

种属: Homo sapiens

同用名: hic-1; ZBTB29; ZNF901

基因 ID: 3090 | 基因类型: protein coding

关于 HIC1

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:2,055,103-2,063,241 (from NCBI)

This gene has 7 transcripts (splice variants), 189 orthologues, 36 paralogues and is associated with 1 phenotype. Broad expression in fat (RPKM 8.9), endometrium (RPKM 4.9) and 19 other tissues.

功能概要

该基因起生长调节和肿瘤抑制基因的作用。该基因区域的超甲基化或缺失与肿瘤和连续基因综合征、Miller-Dieker 综合征有关。该基因的可变剪接导致多个转录变体。[RefSeq 提供，2010 年 9 月]

This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2010]

HIC1 基因产物(2)

mRNA Protein Name
NM_001098202.1 NP_001091672.1 hypermethylated in cancer 1 protein isoform 2
NM_006497.4 NP_006488.2 hypermethylated in cancer 1 protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
15231840 GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
15231840 GOA
enables histone deacetylase binding IDA
IDA: 通过直接分析推断
12052894 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12052894 GOA
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
15231840 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intrinsic apoptotic signaling pathway in response to DNA damage IDA
IDA: 通过直接分析推断
16269335 GOA
involved in negative regulation of Wnt signaling pathway IDA
IDA: 通过直接分析推断
16724116 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12052894 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HIC1 蛋白结构

BTB

BTB: BTB/POZ domain (37 - 152)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (440 - 459)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (507 - 529)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (535 - 557)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (578 - 601)

  • 0
  • 200
  • 400
  • 600
  • 733 a.a.
蛋白主名 其他名称

hypermethylated in cancer 1 protein

hypermethylated in cancer 1

HIC1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
HIC1 Q14526 Ctbp2 Mus musculus P56546
Y2H
16762039
种属间
HIC1 Q14526 Ctbp1 Mus musculus O88712
Y2H
12052894
种属间
HIC1 Q14526 Ctbp1 Mus musculus O88712
Pull Down
12052894
种属间
HIC1 Q14526 Ctbp1 Mus musculus O88712
Anti Bait CoIP
16762039
种属间
HIC1 Q14526 Ctbp1 Mus musculus O88712
Y2H
16762039
种属内
HIC1 Q14526 ARID1A Homo sapiens O14497
Y2H
19486893
种属内
HIC1 Q14526 CTBP2 Homo sapiens P56545
Y2H
19486893
种属内
HIC1 Q14526 CTBP1 Homo sapiens Q13363
Y2H
19486893
种属内
HIC1 Q14526 TCF7L2 Homo sapiens Q9NQB0
Imaging
16724116
种属内
HIC1 Q14526 TCF7L2 Homo sapiens Q9NQB0
Pull Down
16724116
种属内
HIC1 Q14526 TCF7L2 Homo sapiens Q9NQB0
Anti Bait CoIP
16724116
种属内
HIC1 Q14526 TCF7L2 Homo sapiens Q9NQB0
Anti Tag CoIP
16724116
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Miller-Dieker Lissencephaly Syndrome

Miller-Dieker Syndrome

Mds

MDLS

Miller Dieker Syndrome

Classical Lissencephaly Syndrome

Lissencephaly Due To 17p13.3 Deletion

Monosomy 17p13.3

Telomeric Deletion 17p

Classical Lissencephaly
Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Medulloblastoma Predisposition Syndrome

Medulloblastoma, Somatic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Neuroectodermal Tumors, Primitive

Medulloblastomas

Desmoplastic Medulloblastoma

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site
Bilateral Breast Cancer

Bilateral Breast Carcinoma
Adult Central Nervous System Primitive Neuroectodermal Neoplasm

Adult Cns Pnet

Adult Central Nervous System Primitive Neuroectodermal Tumor
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Cleft Palate, Isolated

Cleft Palate

Isolated Cleft Palate

CPI

Cp

Palatoschisis

Cleft Palate Isolated

Uranostaphyloschisis

Congenital Fissure Of Palate

Cleft Of Secondary Palate
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W540188A Calcium mesoxalate trihydrate ≥98.0% 否
HY-RS06165 HIC1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus HIC1 VGNC VGNC:99076
Canis familiaris HIC1 VGNC VGNC:41683
Mus musculus HIC1 MGD MGI:1338010
Rattus norvegicus HIC1 RGD RGD:1307527
Bos taurus HIC1 VGNC VGNC:29845
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