2. Gene
  3. Ctbp1 - C-terminal binding protein 1 Gene

Ctbp1 - C-terminal binding protein 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: BARS; D4S115h; D5H4S115; D5H4S115E; CtBP3/BARS

基因 ID: 13016 | 基因类型: protein coding

关于 Ctbp1

功能概要

Enables chromatin binding activity. Involved in negative regulation of transcription, DNA-templated and white fat cell differentiation. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription repressor complex. Is active in GABA-ergic synapse; glutamatergic synapse; and presynaptic active zone cytoplasmic component. Is expressed in several structures, including central nervous system; genitourinary system; limb; lung; and neural retina. Orthologous to human CTBP1 (C-terminal binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Ctbp1 基因产物(5)

mRNA Protein Name
NM_001198859.1 NP_001185788.1 C-terminal-binding protein 1 isoform 1
NM_001198860.1 NP_001185789.1 C-terminal-binding protein 1 isoform 2
NM_001198861.1 NP_001185790.1 C-terminal-binding protein 1 isoform 4
NM_001310535.1 NP_001297464.1 C-terminal-binding protein 1 isoform 5
NM_013502.3 NP_038530.1 C-terminal-binding protein 1 isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
14701752 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
17392792 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11390982 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
18483224 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
17392792 MGI
involved in synaptic vesicle clustering IDA
IDA: 通过直接分析推断
32075774 MGI
involved in synaptic vesicle clustering IMP
IMP: 通过突变表型推断
32075774 MGI
involved in synaptic vesicle endocytosis IDA
IDA: 通过直接分析推断
32075774 MGI
involved in synaptic vesicle endocytosis IMP
IMP: 通过突变表型推断
32075774 MGI
involved in white fat cell differentiation IDA
IDA: 通过直接分析推断
18483224 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in GABA-ergic synapse IDA
IDA: 通过直接分析推断
22745816 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
22745816 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
32075774 MGI
located in nucleus IDA
IDA: 通过直接分析推断
16702210 MGI
is active in presynaptic active zone cytoplasmic component IDA
IDA: 通过直接分析推断
22745816 MGI
part of transcription repressor complex IDA
IDA: 通过直接分析推断
18483224 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

C-terminal-binding protein 1

Ctbp1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Ctbp1 O88712 HIC1 Homo sapiens Q14526
IF
12052894
种属间
Ctbp1 O88712 HIC1 Homo sapiens Q14526
Anti Tag CoIP
12052894
种属间
Ctbp1 O88712 HIC1 Homo sapiens Q14526
Imaging
16724116
种属间
Ctbp1 O88712 HIC1 Homo sapiens Q14526
Anti Tag CoIP
16762039
种属内
Ctbp1 O88712 Zeb1 Mus musculus Q64318
Anti Tag CoIP
21224849
种属内
Ctbp1 O88712 Zeb1 Mus musculus Q64318
Anti Bait CoIP
17392792
种属内
Ctbp1 O88712 Zeb1 Mus musculus Q64318
Anti Bait CoIP
21224849
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-135046 MTOB sodium Inhibitor 98.24% 否
HY-RS03283 CTBP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ctbp1 NCBI NCBI:1487
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