CTBP2 - C-terminal binding protein 2 Gene

中文名称：C 端结合蛋白 2

种属: Homo sapiens

基因 ID: 1488 | 基因类型: protein coding

关于 CTBP2

Cytogenetic location: 10q26.13 Genomic coordinates (GRCh38): 10:124,984,317-125,162,463 (from NCBI)

This gene has 14 transcripts (splice variants), 200 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 13.6), endometrium (RPKM 9.4) and 24 other tissues.

功能概要

该基因产生编码两种不同蛋白质的替代转录物。一种蛋白质是转录抑制因子，而另一种亚型是称为突触带的特殊突触的主要成分。两种蛋白质都含有一个 NAD+ 结合结构域，类似于 NAD+ 依赖性 2-羟基酸脱氢酶。 3' 非翻译区的一部分用于将该基因映射到染色体 21q21.3；然而，有人指出，基因组其他地方也可能存在类似的位点。 Blast 分析显示该基因存在于 10 号染色体上。已发现该基因编码两种不同亚型的几种转录变体。[RefSeq 提供，2014 年 2 月]

This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the Other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

CTBP2 基因产物(9)

mRNA	Protein	Name
NM_001083914.3	NP_001077383.1	C-terminal-binding protein 2 isoform 1
NM_001290214.3	NP_001277143.1	C-terminal-binding protein 2 isoform 1
NM_001290215.3	NP_001277144.1	C-terminal-binding protein 2 isoform 1
NM_001321012.2	NP_001307941.1	C-terminal-binding protein 2 isoform 1
NM_001321013.2	NP_001307942.1	C-terminal-binding protein 2 isoform 1
NM_001321014.2	NP_001307943.1	C-terminal-binding protein 2 isoform 1
NM_001329.4	NP_001320.1	C-terminal-binding protein 2 isoform 1
NM_001363508.2	NP_001350437.1	C-terminal-binding protein 2 isoform 3
NM_022802.3	NP_073713.2	C-terminal-binding protein 2 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	23393140	GOA
enables protein-containing complex binding	IPI IPI: 通过物理相互作用推断	23393140	GOA
enables transcription corepressor binding	IPI IPI: 通过物理相互作用推断	29628311	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within positive regulation of retinoic acid receptor signaling pathway	IMP IMP: 通过突变表型推断	23775127	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	23775127	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	16702210	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CTBP2 蛋白结构

2-Hacid_dh

2-Hacid_dh_C

0
100
200
300
400
445 a.a.

蛋白主名

其他名称

C-terminal-binding protein 2

ribeye

CTBP2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CTBP2	P56545	CTBP1	Homo sapiens	Q13363-2	Y2H Array	25416956
种属内	CTBP2	P56545	CTBP1	Homo sapiens	Q13363-2	BFG-2H	27107012
种属内	CTBP2	P56545	NOL4	Homo sapiens	O94818-2	Validated Y2H	25416956
种属内	CTBP2	P56545	ZNF750	Homo sapiens	Q32MQ0	Y2H Prey Pooling	25416956
种属内	CTBP2	P56545	ZNF750	Homo sapiens	Q32MQ0	Validated Y2H	25416956
种属内	CTBP2	P56545	ZNF750	Homo sapiens	Q32MQ0	Y2H Array	25416956
种属内	CTBP2	P56545	HIC1	Homo sapiens	Q14526	Anti Bait CoIP	19486893
种属内	CTBP2	P56545	ZNF516	Homo sapiens	Q92618	Anti Tag CoIP	35271311
种属内	CTBP2	P56545	FUNDC1	Homo sapiens	Q8IVP5	Validated Y2H	25416956
种属内	CTBP2	P56545	FUNDC1	Homo sapiens	Q8IVP5	Y2H Prey Pooling	25416956
种属内	CTBP2	P56545	PLCB1	Homo sapiens	Q9NQ66	Y2H Prey Pooling	25416956
种属内	CTBP2	P56545	PLCB1	Homo sapiens	Q9NQ66	Validated Y2H	25416956
种属内	CTBP2	P56545	IKZF2	Homo sapiens	Q9UKS7	Validated Y2H	25416956
种属内	CTBP2	P56545	IKZF2	Homo sapiens	Q9UKS7	Y2H Prey Pooling	25416956
种属内	CTBP2	P56545	PROX1	Homo sapiens	Q92786	Anti Tag CoIP	21988832
种属间	CTBP2	P56545	Zbp1	Mus musculus	A2APF7	Anti Tag CoIP	21903422
种属内	CTBP2	P56545	NOL4L	Homo sapiens	Q96MY1	Y2H Array	25416956
种属内	CTBP2	P56545	NOL4L	Homo sapiens	Q96MY1	Anti Tag CoIP	35271311
种属内	CTBP2	P56545	TGIF1	Homo sapiens	Q15583	Y2H Pooling	16189514
种属内	CTBP2	P56545	TGIF1	Homo sapiens	Q15583	Y2H Array	25416956
种属内	CTBP2	P56545	TGIF1	Homo sapiens	Q15583	Y2H	21516116
种属内	CTBP2	P56545	PPP1R15A	Homo sapiens	O75807	Anti Tag CoIP	21988832
种属内	CTBP2	P56545	PPP1R15A	Homo sapiens	O75807	Y2H	21988832
种属内	CTBP2	P56545	FHL3	Homo sapiens	Q13643	Validated Y2H	27107012
种属内	CTBP2	P56545	CCNH	Homo sapiens	P51946	Confocal	21988832
种属内	CTBP2	P56545	CCNH	Homo sapiens	P51946	Pull Down	21988832
种属内	CTBP2	P56545	IKZF1	Homo sapiens	Q13422	Validated Y2H	25416956
种属内	CTBP2	P56545	IKZF1	Homo sapiens	Q13422	Y2H	21516116
种属内	CTBP2	P56545	LCOR	Homo sapiens	Q96JN0	Y2H Array	31515488
种属内	CTBP2	P56545	LCOR	Homo sapiens	Q96JN0	Y2H Prey Pooling	25416956
种属内	CTBP2	P56545	LCOR	Homo sapiens	Q96JN0	Anti Tag CoIP	35271311
种属内	CTBP2	P56545	LCOR	Homo sapiens	Q96JN0	Validated Y2H	25416956
种属内	CTBP2	P56545	RAI2	Homo sapiens	Q9Y5P3	Y2H Prey Pooling	25416956
种属内	CTBP2	P56545	RAI2	Homo sapiens	Q9Y5P3	Y2H Array	25416956
种属内	CTBP2	P56545	RAI2	Homo sapiens	Q9Y5P3	Y2H Pooling	16189514
种属内	CTBP2	P56545	CTBP1	Homo sapiens	Q13363	Anti Tag CoIP	35271311
种属内	CTBP2	P56545	CTBP1	Homo sapiens	Q13363	Y2H	21988832
种属内	CTBP2	P56545	CTBP1	Homo sapiens	Q13363	Y2H Array	31515488
种属内	CTBP2	P56545	CTBP1	Homo sapiens	Q13363	Anti Bait CoIP	36414381
种属内	CTBP2	P56545	BCL3	Homo sapiens	P20749	Y2H	21988832
种属内	CTBP2	P56545	FOXP2	Homo sapiens	O15409	Y2H Array	25416956
种属内	CTBP2	P56545	FOXP2	Homo sapiens	O15409	Y2H Prey Pooling	25416956
种属内	CTBP2	P56545	FOXP2	Homo sapiens	O15409	Y2H Pooling	21653829

种属间: 跨种属相互作用 种属内: 同种属相互作用

CTBP2 抗体

目录号	产品名	应用	反应物种
HY-P83090	CTBP2 Antibody (YA2835)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat

关联疾病

疾病名称

别名

46,Xy Sex Reversal 9

SRXY9	46,Xy Sex Reversal, Zfpm2-Related
46xy Sex Reversal 9

Developmental And Epileptic Encephalopathy 75

DEE75	Epileptic Encephalopathy, Early Infantile, 75
Eiee75	Developmental And Epileptic Encephalopathy, 75
Early Infantile Epileptic Encephalopathy 75

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Congenital Stationary Night Blindness

Night Blindness, Congenital Stationary	Congenital Essential Nyctalopia
Oguchi Disease	Blindness, Night, Stationary, Congenital

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Leber Plus Disease

Leber Congenital Amaurosis	Lca
Leber'S Amaurosis	Leber'S Disease
Amaurosis Congenita Of Leber	Amaurosis Congenita Of Leber, Type 1
Lhon Plus Disease	Congenital Absence Of The Rods And Cones
Congenital Retinal Blindness	Crb
Congenital Amaurosis Of Retinal Origin	Leber'S Congenital Amaurosis
Leber Congenital Amaurosis 1	Leber'S Congenital Tapetoretinal Degeneration
Leber'S Congenital Tapetoretinal Dysplasia	Lca1
Leber Congenital Amaurosis Type 1	Retinal Blindness, Congenital
Amaurosis, Leber Congenital	Dysgenesis Neuroepithelialis Retinae
Hereditary Epithelial Dysplasia Of Retina	Hereditary Retinal Aplasia
Heredoretinopathia Congenitalis	Leber Abiotrophy
Leber Congenital Tapetoretinal Degeneration	Lebers Congenital Amaurosis
Optic Atrophy, Hereditary, Leber

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-135046	MTOB sodium	Inhibitor	98.24%	否
HY-159131	PNSC928	Inhibitor	/	否
HY-RS03284	CTBP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	CTBP2	VGNC	VGNC:61243
Canis familiaris	CTBP2	VGNC	VGNC:39687
Mus musculus	CTBP2	MGD	MGI:1201686
Rattus norvegicus	CTBP2	RGD	RGD:68372
Macaca mulatta	CTBP2	VGNC	VGNC:103803
Bos taurus	CTBP2	VGNC	VGNC:55942

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