2. Gene
  3. RAI2 - retinoic acid induced 2 Gene

RAI2 - retinoic acid induced 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：视黄酸诱导 2

种属: Homo sapiens

基因 ID: 10742 | 基因类型: protein coding

关于 RAI2

Cytogenetic location: Xp22.13 Genomic coordinates (GRCh38): X:17,800,049-17,861,298 (from NCBI)

This gene has 6 transcripts (splice variants), 169 orthologues and 1 paralogue. Ubiquitous expression in endometrium (RPKM 19.5), ovary (RPKM 15.2) and 23 other tissues.

功能概要

视黄酸在发育、细胞生长和分化中起着关键作用。这种视黄酸诱导基因的具体功能尚未确定，但它可能在发育中发挥作用。该基因的染色体位置表明它是 Nance-Horan 综合征、感音神经性耳聋、非特异性 X 连锁认知障碍、口-面-指综合征和 Fried 综合征等疾病的候选基因。交替剪接导致多个转录本变体。[RefSeq 提供，2010 年 2 月]

Retinoic acid plays a critical role in development, cellular growth, and differentiation. The specific function of this retinoic acid-induced gene has not yet been determined but it may play a role in development. The chromosomal location of this gene designates it to be a candidate for diseases such as Nance-Horan syndrome, sensorineural deafness, non-specific X-linked cognitive disability, oral-facial-digital syndrome, and Fried syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

RAI2 基因产物(4)

mRNA Protein Name
NM_001172732.2 NP_001166203.2 retinoic acid-induced protein 2 isoform 2
NM_001172739.2 NP_001166210.2 retinoic acid-induced protein 2 isoform 1
NM_001172743.2 NP_001166214.2 retinoic acid-induced protein 2 isoform 1
NM_021785.6 NP_068557.4 retinoic acid-induced protein 2 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RAI2 蛋白结构

SOBP

SOBP: Sine oculis-binding protein (106 - 250)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 530 a.a.
蛋白主名 其他名称

retinoic acid-induced protein 2

RAI2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RAI2 Q9Y5P3 CTBP2 Homo sapiens P56545-3
Validated Y2H
25416956
种属内
RAI2 Q9Y5P3 GTF3C3 Homo sapiens Q9Y5Q9
Validated Y2H
32814053
种属内
RAI2 Q9Y5P3 GTF3C3 Homo sapiens Q9Y5Q9
Y2H Array
32814053
种属内
RAI2 Q9Y5P3 GTF3C3 Homo sapiens Q9Y5Q9
Y2H Pooling
32814053
种属内
RAI2 Q9Y5P3 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
种属内
RAI2 Q9Y5P3 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
种属内
RAI2 Q9Y5P3 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
种属内
RAI2 Q9Y5P3 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
种属内
RAI2 Q9Y5P3 HSPB1 Homo sapiens P04792
Y2H Array
32814053
种属内
RAI2 Q9Y5P3 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
种属内
RAI2 Q9Y5P3 NEFL Homo sapiens P07196
Validated Y2H
32814053
种属内
RAI2 Q9Y5P3 NEFL Homo sapiens P07196
Y2H Array
32814053
种属内
RAI2 Q9Y5P3 NEFL Homo sapiens P07196
Y2H Pooling
32814053
种属内
RAI2 Q9Y5P3 FHL2 Homo sapiens Q14192
Y2H Array
31515488
种属内
RAI2 Q9Y5P3 FHL2 Homo sapiens Q14192
Y2H Prey Pooling
25416956
种属内
RAI2 Q9Y5P3 UBQLN4 Homo sapiens Q9NRR5
Y2H Array
16713569
种属内
RAI2 Q9Y5P3 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
种属内
RAI2 Q9Y5P3 WFS1 Homo sapiens O76024
Validated Y2H
32814053
种属内
RAI2 Q9Y5P3 WFS1 Homo sapiens O76024
Y2H Array
32814053
种属内
RAI2 Q9Y5P3 CTBP2 Homo sapiens P56545
Validated Y2H
25416956
种属内
RAI2 Q9Y5P3 SGTB Homo sapiens Q96EQ0
Y2H Array
29892012
种属内
RAI2 Q9Y5P3 SGTB Homo sapiens Q96EQ0
Y2H Pooling
16189514
种属内
RAI2 Q9Y5P3 SGTB Homo sapiens Q96EQ0
Validated Y2H
25416956
种属内
RAI2 Q9Y5P3 SGTB Homo sapiens Q96EQ0
Y2H Array
25416956
种属内
RAI2 Q9Y5P3 PRPS1 Homo sapiens P60891
Y2H Array
32814053
种属内
RAI2 Q9Y5P3 PRPS1 Homo sapiens P60891
Y2H Pooling
32814053
种属内
RAI2 Q9Y5P3 PRPS1 Homo sapiens P60891
Validated Y2H
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Nance-Horan Syndrome

NHS

Cataract-Dental Syndrome

Cataract, X-Linked, With Hutchinsonian Teeth

Mesiodens-Cataract Syndrome

Cataract X-Linked With Hutchinsonian Teeth

Cataract Dental Syndrome

Mesiodens Cataract Syndrome
Decubitus Ulcer

Pressure Ulcer

Pressure Sores

Pressure Ulcers

Bedsore

Decubitus Ulcer

Decubitus Ulcer Any Site
Cataract

Cataracts

Cat - [Cataract]

Cataract Form

Lens Opacity

Lens Opacities
Tetralogy Of Fallot

TOF

Fallot Tetralogy

Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle

Tetrad Of Fallot

Fallot Tetrad

Fallot Disease

Fallot Complex

Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy

Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle

Interventricular Septal Defect, In Tetralogy Of Fallot

Ventricular Septal Defect With Obstructed Right Ventricular Outflow

Tof - [Tetralogy Of Fallot]

Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]

Pulmonary Atresia, Ventricular Septal Defect And Mapcas

Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11626 RAI2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus RAI2 MGD MGI:1344378
Macaca mulatta RAI2 VGNC VGNC:76652
Rattus norvegicus RAI2 RGD RGD:1560139
Bos taurus RAI2 VGNC VGNC:33697
Felis catus RAI2 VGNC VGNC:69225
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