PROX1 - prospero homeobox 1 Gene

中文名称：普洛斯彼罗同源盒 1

种属: Homo sapiens

基因 ID: 5629 | 基因类型: protein coding

关于 PROX1

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:213,983,151-214,041,510 (from NCBI)

This gene has 7 transcripts (splice variants), 210 orthologues and 1 paralogue. Biased expression in liver (RPKM 20.2), adrenal (RPKM 5.1) and 13 other tissues.

功能概要

该基因编码的蛋白质是同源框转录因子家族的成员。该家族的成员包含一个同源框结构域，该结构域由结合 DNA 和 RNA 的 60 个氨基酸的螺旋-转角-螺旋结构组成。由该基因编码的蛋白质在脊椎动物中是保守的，并且可能在发育过程中发挥重要作用。据报道，这种蛋白质水平的改变发生在不同器官的癌症中，例如结肠癌、脑癌、血液癌、乳腺癌、胰腺癌、肝癌和食道癌。可变剪接导致多个转录本变体。[RefSeq 提供，2012 年 7 月]

The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

PROX1 基因产物(2)

mRNA	Protein	Name
NM_001270616.2	NP_001257545.1	prospero homeobox protein 1
NM_002763.5	NP_002754.2	prospero homeobox protein 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IMP IMP: 通过突变表型推断	18815287	GOA
enables DNA binding domain binding	IPI IPI: 通过物理相互作用推断	15205472	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	15143342	GOA
enables LBD domain binding	IPI IPI: 通过物理相互作用推断	15143342	GOA
enables nuclear receptor binding	IPI IPI: 通过物理相互作用推断	15143342	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	15205472	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: 通过直接分析推断	19210544	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in brain development	IEP IEP: 通过表达模式推断	8812486	GOA
involved in embryonic retina morphogenesis in camera-type eye	IEP IEP: 通过表达模式推断	12692551	GOA
involved in hepatocyte differentiation	IEP IEP: 通过表达模式推断	15232737	GOA
involved in kidney development	IEP IEP: 通过表达模式推断	8812486	GOA
involved in lens development in camera-type eye	IEP IEP: 通过表达模式推断	8812486	GOA
involved in lens fiber cell morphogenesis	IEP IEP: 通过表达模式推断	11850194	GOA
involved in liver development	IEP IEP: 通过表达模式推断	11789987	GOA
involved in lung development	IEP IEP: 通过表达模式推断	8812486	GOA
involved in lymphangiogenesis	IDA IDA: 通过直接分析推断	12412020	GOA
involved in lymphatic endothelial cell differentiation	IDA IDA: 通过直接分析推断	12198161	GOA
involved in lymphatic endothelial cell fate commitment	IMP IMP: 通过突变表型推断	18815287	GOA
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	15205472	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	15143342	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	16488887	GOA
involved in negative regulation of bile acid biosynthetic process	IMP IMP: 通过突变表型推断	16488887	GOA
involved in negative regulation of cell population proliferation	IMP IMP: 通过突变表型推断	17062673	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	15205472	GOA
involved in negative regulation of viral genome replication	IDA IDA: 通过直接分析推断	19264593	GOA
involved in pancreas development	IEP IEP: 通过表达模式推断	11789987	GOA
involved in positive regulation of cell population proliferation	IDA IDA: 通过直接分析推断	12198161	GOA
involved in positive regulation of cyclin-dependent protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	19210544	GOA
involved in positive regulation of endothelial cell migration	IDA IDA: 通过直接分析推断	19210544	GOA
involved in positive regulation of endothelial cell proliferation	IDA IDA: 通过直接分析推断	19210544	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	18815287	GOA
involved in regulation of circadian rhythm	IMP IMP: 通过突变表型推断	23723244	GOA
involved in regulation of gene expression	IDA IDA: 通过直接分析推断	12198161	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	11850194	GOA
located in nucleus	IDA IDA: 通过直接分析推断	11850194	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PROX1 蛋白结构

HPD

0
200
400
600
737 a.a.

蛋白主名

其他名称

prospero homeobox protein 1

homeobox prospero-like protein PROX1

PROX1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PROX1	Q92786	HNF1A	Homo sapiens	P20823	Anti Tag CoIP	19264593
种属内	PROX1	Q92786	HNF1A	Homo sapiens	P20823	Pull Down	19264593
种属内	PROX1	Q92786	CTBP2	Homo sapiens	P56545	Y2H	21988832
种属内	PROX1	Q92786	NR5A2	Homo sapiens	O00482-2	Pull Down	15205472
种属内	PROX1	Q92786	NR5A2	Homo sapiens	O00482-2	Anti Bait CoIP	15205472
种属内	PROX1	Q92786	NR5A2	Homo sapiens	O00482-2	Confocal	15205472
种属内	PROX1	Q92786	NR5A2	Homo sapiens	O00482-2	Y2H	15205472
种属内	PROX1	Q92786	NR5A2	Homo sapiens	O00482-2	Gal4 VP16 Complement	15205472

种属间: 跨种属相互作用 种属内: 同种属相互作用

PROX1 抗体

目录号	产品名	应用	反应物种
HY-P82009	PROX1 Antibody (YA1754)	WB	Rat

关联疾病

疾病名称

别名

Generalized Lymphatic Anomaly

Doid:0081031

Hereditary Lymphedema I

Lymphedema	Hereditary Lymphedema Type I
Congenital Primary Lymphedema	Lmph1
Milroy Disease	Nonne-Milroy Lymphedema
Pcl	Lymphedema Hereditary Type 1

Lymphangioma

Lymphatic Malformation	Lymphatic Malformations
Benign Lymphangioma	Congenital Lymphangioma
Lymphangiomas

Angiokeratoma Of Fordyce

Fordyce Angiokeratoma	Fordyce'S Spot
Fordyce-Type Angiokeratoma Of Scrotum

Acquired Hemangioma

Malignant Ciliary Body Melanoma

Malignant Melanoma Of Ciliary Body

Melanoma Of The Ciliary Body

Ciliary Body Cancer

Malignant Neoplasm Of Ciliary Body	Malignant Tumor Of Ciliary Body
Malignant Tumor Of The Ciliary Body	Neoplasm Of Ciliary Body
Tumor Of The Ciliary Body	Primary Malignant Neoplasm Of Ciliary Body
Malignant Neoplasm Of Eyeball	Malignant Neoplasm Of Uveal Tract
Primary Malignant Neoplasm Of Sclera	Primary Malignant Neoplasm Of Uveal Tract

Hemangioma

Hemangiomas

Lymphangiosarcoma

Skin Lymphangiosarcoma	Stewart Treves Syndrome
Lymphangiosarcoma Of Stewart And Treves	Malignant Lymphangioendothelioma
Stewart-Treves Syndrome

Capillary Lymphangioma

Microcystic Lymphatic Malformation	Capillary Lymphatic Malformation
Microcystic Infiltrating Lymphatic Malformation	Microcystic Lymphangioma
Superficial Lymphangioma	Cutaneous Lymphangioma Circumscriptum
Superficial Lymphatic Malformation	Cutaneous Lymphangioma
Lymphangioma Of Skin	Lymphangioma Circumscriptum

Hypotrichosis-Lymphedema-Telangiectasia Syndrome

HLTS	Hypotrichosis Lymphedema Telangiectasia Syndrome
Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome	Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome

Spindle Cell Hemangioma

Sch	Spindle Cell Hemangioendothelioma

Inflammatory Breast Carcinoma

Inflammatory Breast Cancer	Inflammatory Carcinoma Of Breast
Mastitis Carcinomatosa	Breast Cancer, Inflammatory
Inflammatory Breast Neoplasms	Inflammatory Adenocarcinoma Of Breast

Gorham'S Disease

Gorham-Stout Syndrome	Osteolysis, Essential
Disappearing Bone Disease	Essential Osteolysis
Gorham Disease	Massive Osteolysis
Phantom Bone Disease	Cystic Angiomatosis Of Bone Diffuse
Gorham-Stout Disease	Osteolysis Massive
Vanishing Bone Disease	Massive Osteolyses

Hereditary Lymphedema

Milroy Disease

Mucocele Of Salivary Gland

Ranula	Salivary Cyst
Salivary Gland Mucocele	Mucous Retention Cyst Of Salivary Gland
Retention Cyst Of Salivary Gland	Sialocele
Cyst Of Salivary Gland Or Duct	Extravasation Cyst Of Salivary Gland

Cystic Lymphangioma

Cystic Hygroma	Cavernous Lymphangioma
Macrocystic Lymphatic Malformation	Cavernous Lymphatic Malformation
Macrocystic Lymphangioma	Lymphangioma, Cystic

Lymphedema-Distichiasis Syndrome

Lymphedema With Distichiasis	Lymphedema-Distichiasis Syndrome With Renal Disease And Diabetes Mellitus
LPHDST	Distichiasis-Lymphedema Syndrome
Lymphedema Distichiasis Syndrome	Hereditary Lymphedema-Distichiasis Syndrome
Lymphedema Distichiasis

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Capillary Hemangioma

Infantile Hemangioma	Strawberry Nevus Of Skin
Cellular Hemangioma Of Infancy	Congenital Vascular Hamartoma
Congenital Vascular Naevus	Juvenile Hemangioma
Strawberry Haemangioma	Strawberry Nevus
Hemangioma Capillary	Hemangioma, Capillary
Hemangioma, Cavernous

Cerebral Cavernous Malformations

Cerebral Cavernous Malformation	Cavernous Malformations Of Cns And Retina
Cerebral Cavernous Malformation 1	Cavernous Angiomatous Malformations
Cerebral Capillary Malformations	CCM
Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations	Familial Cavernous Angioma
Cavernous Angioma	Familial Cerebral Cavernous Malformation
Cerebral Cavernous Malformations 1	Cavernous Angioma, Familial
Cam	Cerebral Cavernous Malformations-1
Cavernoma	Central Nervous System Cavernous Hemangioma
Cerebral Cavernous Hemangioma	Familial Cavernous Hemangioma
Familial Cavernous Malformation	Familial Cerebral Cavernous Angioma
Intracerebral Cavernous Hemangioma	CCM1
Cavernous Hemangioma Of The Brain	Cerebral Cavernoma
Cerebral Cavernous Malformations, Type 1	Hemangioma, Cavernous, Central Nervous System
Hemangioma, Cavernous	Angioma, Cavernous

Hennekam Syndrome

Hennekam Lymphangiectasia Lymphedema Syndrome	Hennekam Lymphangiectasia-Lymphedema Syndrome
Lymphedema-Lymphangiectasia-Intellectual Disability Syndrome	Lymphedem-Lymphangiectasia-Intellectual Disability Syndrome
Intestinal Lymphagiectasia Lymphedema Intellectual Deficit Syndrome	Lymphangiectasies And Lymphedema Hennekam Type
Generalized Lymphatic Dysplasia	Intestinal Lymphagiectasia-Lymphedema-Mental Retardation Syndrome

Klippel-Trenaunay-Weber Syndrome

Klippel-Trenaunay Syndrome	KTS
Ktw Syndrome	Angioosteohypertrophy Syndrome
Angio-Osteohypertrophy Syndrome	Klippel Trenaunay Syndrome
Klippel-Trénaunay-Weber Syndrome	Haemangiectatic Hypertrophy
Weber-Klippel-Trenaunay	Congenital Dysplastic Angiopathy
Klippel-Trenaunay Disease	Weber Klippel Trenaunay

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11203	PROX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	PROX1	VGNC	VGNC:76427
Mus musculus	PROX1	MGD	MGI:97772
Canis familiaris	PROX1	VGNC	VGNC:45017
Felis catus	PROX1	VGNC	VGNC:69080
Bos taurus	PROX1	VGNC	VGNC:33369
Rattus norvegicus	PROX1	RGD	RGD:1306890

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PROX1 - prospero homeobox 1 Gene

关于 PROX1

功能概要

PROX1 基因产物(2)

PROX1 蛋白结构

PROX1 蛋白互作信息

PROX1 抗体

关联疾病

直系同源

热门区域

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PROX1 - prospero homeobox 1 Gene

关于 PROX1

功能概要

PROX1 基因产物(2)

PROX1 蛋白结构

PROX1 蛋白互作信息

PROX1 抗体

关联疾病

相关产品

直系同源

热门区域

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F

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