2. Gene
  3. BCL3 - BCL3 transcription coactivator Gene

BCL3 - BCL3 transcription coactivator Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：BCL3 转录辅激活因子

种属: Homo sapiens

同用名: BCL4; D19S37

基因 ID: 602 | 基因类型: protein coding

关于 BCL3

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:44,747,705-44,760,044 (from NCBI)

This gene has 9 transcripts (splice variants), 173 orthologues, 16 paralogues and is associated with 52 phenotypes. Ubiquitous expression in bone marrow (RPKM 8.4), small intestine (RPKM 7.7) and 24 other tissues.

功能概要

该基因是原癌基因候选者。在某些 B 细胞白血病病例中，它通过易位到免疫球蛋白 α 基因座来识别。该基因编码的蛋白质包含七个锚蛋白重复序列，与 I kappa B 蛋白中发现的那些最密切相关。这种蛋白质作为转录共激活因子起作用，通过与 NF-kappa B 同型二聚体结合激活。该基因的表达可由 NF-kappa B 诱导，NF-kappa B 构成控制 p50 NF-kappa B 核驻留的自动调节环的一部分。[RefSeq 提供，2008 年 7 月]

This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]

BCL3 基因产物(1)

mRNA Protein Name
NM_005178.5 NP_005169.2 B-cell lymphoma 3 protein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
8196632 GOA
enables histone deacetylase binding IPI
IPI: 通过物理相互作用推断
16306601 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10362352 GOA
enables protein-macromolecule adaptor activity IDA
IDA: 通过直接分析推断
16306601 GOA
enables transcription corepressor activity IDA
IDA: 通过直接分析推断
16306601 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IDA
IDA: 通过直接分析推断
16384933 GOA
involved in DNA damage response, signal transduction by p53 class mediator IMP
IMP: 通过突变表型推断
16384933 GOA
involved in canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
8196632 GOA
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
IMP: 通过突变表型推断
16384933 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
16306601 GOA
involved in negative regulation of NF-kappaB transcription factor activity IDA
IDA: 通过直接分析推断
16306601 GOA
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
16384933 GOA
involved in negative regulation of interleukin-8 production IMP
IMP: 通过突变表型推断
16306601 GOA
involved in negative regulation of receptor signaling pathway via JAK-STAT IMP
IMP: 通过突变表型推断
16306601 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
16384933 GOA
involved in positive regulation of translation IMP
IMP: 通过突变表型推断
16384933 GOA
involved in protein import into nucleus IDA
IDA: 通过直接分析推断
8196632 GOA
involved in regulation of DNA binding IEP
IEP: 通过表达模式推断
9407099 GOA
involved in regulation of apoptotic process IDA
IDA: 通过直接分析推断
16732314 GOA
involved in regulation of non-canonical NF-kappaB signal transduction IEP
IEP: 通过表达模式推断
8196632 GOA
involved in response to UV-C IDA
IDA: 通过直接分析推断
16384933 GOA
involved in response to virus IDA
IDA: 通过直接分析推断
16306601 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Bcl3-Bcl10 complex IDA
IDA: 通过直接分析推断
16280327 GOA
part of Bcl3/NF-kappaB2 complex IDA
IDA: 通过直接分析推断
9407099 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
11387332 GOA
located in nucleus IDA
IDA: 通过直接分析推断
8196632 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
16280327 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BCL3 蛋白结构

Ank

Ank: Ankyrin repeat (134 - 156)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (168 - 228)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (242 - 305)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 454 a.a.
蛋白主名 其他名称

B-cell lymphoma 3 protein

B cell CLL/lymphoma 3

BCL3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
BCL3 P20749 LCK Homo sapiens P06239
Pull Down
16099425
种属内
BCL3 P20749 CTBP2 Homo sapiens P56545
Anti Tag CoIP
21988832
种属内
BCL3 P20749 BCL10 Homo sapiens O95999
Pull Down
16280327
种属内
BCL3 P20749 BCL10 Homo sapiens O95999
Anti Bait CoIP
16280327
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
B-Cell Lymphoma

Lymphoma, B-Cell

B-Cell Lymphomas

B-Cell Lymphocytic Neoplasm

Lymphoma B-Cell

B-Cell Lymphoma Nos
Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos
Leukemia

Leukemias

Leukaemia, Unspecified, Without Mention Of Remission

Aleukemic Leukaemia

Chronic Leukaemia

Subacute Leukaemia

Leukaemia Disorder

Leukaemia Nos
Leukemia, Chronic Lymphocytic 2

Leukemia, Chronic Lymphocytic, Susceptibility To, 2

B-Cell Malignancy, Low-Grade

Clls2

Disrupted In B-Cell Malignancy

Dbm

Leukemia, Chronic Lymphocytic, B-Cell

Bcll

Lymphocytic Leukemia Chronic B-Cell

Chronic Lymphocytic Leukemia

Chronic Lymph Leukaemia

Chronic Lymphatic Leukaemia

Chronic Lymphocytic Leukaemia

Chronic Lymphoid Leukaemia

Lymphoplasmacytic Leukaemia
Chromosomal Triplication

Trisomy
Anaplastic Large Cell Lymphoma

Alcl

Cd30 Positive Anaplastic Large Cell Lymphoma

Ki-1 Positive Anaplastic Large Cell Lymphoma

Primary Systemic Alcl

Sacl

Ki-1+ Anaplastic Large Cell Lymphoma
Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma

Lymphoma, Non-Hodgkin

NHL

Lymphoma, Non-Hodgkin, Somatic

Lymphoma, Follicular, Somatic

Familial Non-Hodgkin Lymphoma

Lymphoma Non-Hodgkins

Follicular Lymphoma, Somatic

Lymphosarcoma

Non-Hodgkins Lymphoma
Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell
Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma

Hodgkin Disease

Hodgkin'S Lymphoma

Hodgkins Lymphoma

Classic Hodgkin Lymphoma

CHL

Hodgkin Lymphoma, Susceptibility To

Hl

Hodgkin'S Sarcoma

Stage I Subdiaphragmatic Hodgkin Lymphoma

Stage Ii Subdiaphragmatic Hodgkin Lymphoma

Lymphoma, Hodgkin'S

Classic Hodgkin Disease

Hodgkin'S Disease

Lymphoma, Hodgkin, Susceptibility To

Hodgkin'S Disease Of Intrapelvic Lymph Nodes

Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb

Malignant Lymphogranuloma

Malignant Lymphogranulomatosis

Malignant Hodgkin Lymphoma

Classical Hodgkin Lymphoma, Type Not Specified
Peripheral T-Cell Lymphoma

Lymphoma T-Cell Peripheral
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-14454 TPh A Inhibitor 99.81% 否
HY-152177 JS6 Inhibitor 99.67% 否
HY-RS01437 BCL3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus BCL3 MGD MGI:88140
Rattus norvegicus BCL3 RGD RGD:1589465
Felis catus BCL3 VGNC VGNC:69302
Macaca mulatta BCL3 VGNC VGNC:108478
Canis familiaris BCL3 VGNC VGNC:59228
Bos taurus BCL3 VGNC VGNC:58663
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