IKZF2 - IKAROS family zinc finger 2 Gene

中文名称：IKAROS 家族锌指 2

种属: Homo sapiens

同用名: ANF1A2; HELIOS; ZNF1A2; ZNFN1A2

关于 IKZF2

功能概要

该基因编码锌指蛋白 Ikaros 家族的一个成员。该蛋白家族的三个成员 (Ikaros、Aiolos 和 Helios) 是参与淋巴细胞发育调节的造血特异性转录因子。这种蛋白质与其他 Ikaros 家族成员形成同二聚体或异二聚体，被认为主要在早期造血发育中发挥作用。已发现该基因编码不同亚型的多个转录变体，但尚未确定某些变体的生物学有效性。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with Other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]