2. Gene
  3. THAP11 - THAP domain containing 11 Gene

THAP11 - THAP domain containing 11 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 THAP 域 11

种属: Homo sapiens

同用名: RONIN; CTG-B43a; CTG-B45d; HRIHFB2206

基因 ID: 57215 | 基因类型: protein coding

关于 THAP11

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,842,320-67,844,195 (from NCBI)

This gene has 1 transcript (splice variant) and 175 orthologues.

功能概要

该基因编码的蛋白质包含一个 THAP 结构域，这是一个保守的 DNA 结合结构域，与果蝇 P 元件转座酶的位点特异性 DNA 结合结构域 (DBD) 具有惊人的相似性。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases. [provided by RefSeq, Jul 2008]

THAP11 基因产物(1)

mRNA Protein Name
NM_020457.3 NP_065190.2 THAP domain-containing protein 11
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
23306615 GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
19008924 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
19008924 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18330356 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
23306615 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
19008924 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

THAP11 蛋白结构

THAP

THAP: THAP domain (5 - 66)

  • 0
  • 100
  • 200
  • 314 a.a.
蛋白主名 其他名称

THAP domain-containing protein 11

THAP11 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Cross THAP11 Q96EK4 Casp3 Mus musculus P70677
Protease Assay
18585351
Intra THAP11 Q96EK4 VPS52 Homo sapiens Q8N1B4
Y2H Array
25416956
Intra THAP11 Q96EK4 VPS52 Homo sapiens Q8N1B4
Y2H Prey Pooling
25416956
Intra THAP11 Q96EK4 PSMC5 Homo sapiens P62195
Y2H
18330356
Intra THAP11 Q96EK4 HCFC1 Homo sapiens P51610
Y2H
18585351
Intra THAP11 Q96EK4 HCFC1 Homo sapiens P51610
Anti Tag CoIP
33961781
Intra THAP11 Q96EK4 CTBP1 Homo sapiens Q13363
Anti Tag CoIP
33961781
Intra THAP11 Q96EK4 CTBP1 Homo sapiens Q13363
Y2H Array
21988832
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Disorders Of Intracellular Cobalamin Metabolism
Methylmalonic Aciduria And Homocystinuria, Cblx Type

Mental Retardation, X-Linked 3

Methylmalonic Acidemia With Homocystinuria, Type Cblx

MAHCX

Intellectual Developmental Disorder, X-Linked 3

Xlid3

Mrx3

Methylmalonic Acidemia And Homocysteinemia Cblx Type

Combined Defect In Adenosylcobalamin And Methylcobalamin Synthesis, Type Cblx

Methylmalonic Aciduria With Homocystinuria, Type Cblx

Methylmalonic Acidemia And Homocysteinemia, Cblx Type

Methylmalonic Aciduria And Homocysteinemia, Cblx Type

Methylmalonic Aciduria And Homocysteinemia , Cblx Type

Mental Retardation, X-Linked, Type 3
Methylmalonic Acidemia

Methylmalonic Aciduria

Mma

Acidemia, Methylmalonic

Isolated Methylmalonic Acidemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14471 THAP11 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus THAP11 VGNC VGNC:66149
Bos taurus THAP11 VGNC VGNC:35819
Canis familiaris THAP11 VGNC VGNC:47325
Rattus norvegicus THAP11 RGD RGD:1310268
Mus musculus THAP11 MGD MGI:1930964
Macaca mulatta THAP11 VGNC VGNC:79381
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