PSMC5 - proteasome 26S subunit, ATPase 5 Gene

中文名称：蛋白酶体 26S 亚基，ATPase 5

种属: Homo sapiens

同用名: S8; p45; RPT6; SUG1; SUG-1; TBP10; TRIP1; p45/SUG

关于 PSMC5

功能概要

26S 蛋白酶体是一种多催化蛋白酶复合物，具有由 2 个复合物、20S 核心和 19S 调节剂组成的高度有序结构。 20S 核心由 28 个不同亚基的 4 个环组成； 2 个环由 7 个α亚基组成，2 个环由 7 个β亚基组成。 19S 调节器由一个包含 6 个 ATP 酶亚基和 2 个非 ATP 酶亚基的碱基和一个包含多达 10 个非 ATP 酶亚基的盖子组成。蛋白酶体以高浓度分布在整个真核细胞中，并在非溶酶体途径中以 ATP/泛素依赖性过程切割肽。修饰的蛋白酶体 (免疫蛋白酶体) 的基本功能是加工 I 类 MHC 肽。该基因编码一个 ATP 酶亚基，它是具有伴侣样活性的 ATP 酶三 A 家族的成员。除了参与蛋白酶体功能外，该亚基还可能参与转录调节，因为它已被证明与甲状腺激素受体和维甲酸 X 受体-α 相互作用。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2010 年 11 月]

The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in Proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the Thyroid Hormone Receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]