RORC - RAR related orphan receptor C Gene

中文名称：RAR 相关孤儿受体 C

种属: Homo sapiens

同用名: TOR; RORG; RZRG; IMD42; NR1F3; RZR-GAMMA

基因 ID: 6097 | 基因类型: protein coding

关于 RORC

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,806,071-151,831,802 (from NCBI)

This gene has 11 transcripts (splice variants), 383 orthologues, 18 paralogues and is associated with 2 phenotypes. Broad expression in liver (RPKM 16.0), thyroid (RPKM 15.9) and 18 other tissues.

功能概要

该基因编码的蛋白质是一种 DNA 结合转录因子，是核激素受体 NR1 亚家族的成员。这种蛋白质的具体功能尚不清楚；然而，对小鼠中类似基因的研究表明，该基因可能对淋巴器官发生至关重要，并可能在胸腺生成中发挥重要的调节作用。此外，小鼠研究表明，该基因编码的蛋白质可能会抑制 Fas 配体和 IL2 的表达。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RORC 基因产物(4)

mRNA	Protein	Name
NM_001001523.2	NP_001001523.1	nuclear receptor ROR-gamma isoform b
NM_005060.4	NP_005051.2	nuclear receptor ROR-gamma isoform a
XM_006711484.5	XP_006711547.3	nuclear receptor ROR-gamma isoform X2
XM_047427201.1	XP_047283157.1	nuclear receptor ROR-gamma isoform X1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	20427770	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	20427770	GOA
enables ligand-activated transcription factor activity	IDA IDA: 通过直接分析推断	19965867	GOA
enables oxysterol binding	IDA IDA: 通过直接分析推断	19965867	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	18368049	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to sterol	IDA IDA: 通过直接分析推断	19965867	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	20427770	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	19965867	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RORC 蛋白结构

zf-C4

Hormone_recep

0
100
200
300
400
518 a.a.

蛋白主名

其他名称

nuclear receptor ROR-gamma

nuclear receptor RZR-gamma	nuclear receptor subfamily 1 group F member 3
retinoic acid-binding receptor gamma	retinoid-related orphan receptor gamma

RORC 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	RORC	P51449	PSMC5	Homo sapiens	P62195	Validated Y2H	32296183
Intra	RORC	P51449	NCOA1	Homo sapiens	Q15788	Alpha-Screen	20203100
Cross	RORC	P51449	Clock	Mus musculus	O08785	Anti Tag CoIP	23555304

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Nail Disease

Nail Diseases	Abnormality Of The Nail
Nail Anomaly

Hyper Ige Syndrome

Hyper-Ige Syndrome	Hyper Immunoglobulin E Syndrome
Hies	Hyper-Ige Recurrent Infection Syndrome
Hyperimmunoglobulin E Syndrome	Hyper Ige
Job Syndrome	Hartnup Disease

Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous	Cmc
Candidiasis Chronic Mucocutaneous

Immunodeficiency 42

Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Rorgamma Receptor Deficiency	IMD42
Autosomal Recessive Msmd Due To Complete Rorgamma Receptor Defiency	Autosomal Recessive Primary Immunodeficiency Due To Rorc Mutation

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behet'S Syndrome
Bd Syndrome	Behçet Syndrome
Behçet'S Disease	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Candidiasis

Systemic Candidiasis	Invasive Candidiasis
Disseminated Candidiasis	Systemic Candida Infections
Candidiasis, Invasive

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-19775	GNE-6468	Antagonist	98.04%	否
HY-112706	PF-06747711	Antagonist	99.86%	否
HY-19774	GNE-0946	Inhibitor	98.09%	否
HY-128353	ROR agonist-1	Antagonist	/	否
HY-148237	JNJ-54119936	Antagonist	/	否
HY-16983	GNE-3500	Antagonist	/	否
HY-RS12132	RORC Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS12133	Rorc Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS12134	Rorc Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	RORC	VGNC	VGNC:45697
Rattus norvegicus	RORC	RGD	RGD:1595785
Mus musculus	RORC	MGD	MGI:104856
Bos taurus	RORC	VGNC	VGNC:34090
Macaca mulatta	RORC	VGNC	VGNC:76719
Felis catus	RORC	VGNC	VGNC:64723
Others	RORC	NCBI

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