2. Gene
  3. PSMC4 - proteasome 26S subunit, ATPase 4 Gene

PSMC4 - proteasome 26S subunit, ATPase 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白酶体 26S 亚基，ATPase 4

种属: Homo sapiens

同用名: S6; RPT3; TBP7; TBP-7; MIP224

基因 ID: 5704 | 基因类型: protein coding

关于 PSMC4

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,971,165-39,981,764 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 198 orthologues and 5 paralogues. Ubiquitous expression in thyroid (RPKM 29.3), brain (RPKM 25.9) and 25 other tissues.

功能概要

26S 蛋白酶体是一种多催化蛋白酶复合物，具有由 2 个复合物、20S 核心和 19S 调节剂组成的高度有序结构。 20S 核心由 28 个不同亚基的 4 个环组成； 2 个环由 7 个α亚基组成，2 个环由 7 个β亚基组成。 19S 调节器由一个包含 6 个 ATP 酶亚基和 2 个非 ATP 酶亚基的碱基和一个包含多达 10 个非 ATP 酶亚基的盖子组成。蛋白酶体以高浓度分布在整个真核细胞中，并在非溶酶体途径中以 ATP/泛素依赖性过程切割肽。该基因编码 ATP 酶 3A 家族的一个成员，该家族是 19S 调节亚基的一个组成部分，并在 26S 蛋白酶体组装中发挥作用。编码的蛋白质与肝癌蛋白 gankyrin 相互作用，并且还可能通过与 synphilin-1 的相互作用在帕金森病中发挥作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2012 年 7 月]

The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S Proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

PSMC4 基因产物(2)

mRNA Protein Name
NM_006503.4 NP_006494.1 26S proteasome regulatory subunit 6B isoform 1
NM_153001.3 NP_694546.1 26S proteasome regulatory subunit 6B isoform 2
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12525503 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of proteasome complex IDA
IDA: 通过直接分析推断
17323924 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PSMC4 蛋白结构

AAA

AAA: ATPase family associated with various cellular activities (AAA) (202 - 335)

  • 0
  • 100
  • 200
  • 300
  • 418 a.a.
蛋白主名 其他名称

26S proteasome regulatory subunit 6B

26S protease regulatory subunit 6B

PSMC4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PSMC4 P43686 NEK7 Homo sapiens Q8TDX7
Y2H Pooling
32814053
种属内
PSMC4 P43686 NEK7 Homo sapiens Q8TDX7
Validated Y2H
32814053
种属内
PSMC4 P43686 NEK7 Homo sapiens Q8TDX7
Y2H Array
32814053
种属内
PSMC4 P43686 PSMC1 Homo sapiens P62191
Anti Tag CoIP
33961781
种属内
PSMC4 P43686 PSMC1 Homo sapiens P62191
Anti Tag CoIP
35271311
种属内
PSMC4 P43686 PSMC1 Homo sapiens P62191
Anti Bait CoIP
17353931
种属内
PSMC4 P43686 PSMC1 Homo sapiens P62191
Solution Sedimentation
19490896
种属内
PSMC4 P43686 PSMC6 Homo sapiens P62333
Anti Tag CoIP
33961781
种属内
PSMC4 P43686 PSMC6 Homo sapiens P62333
Anti Tag CoIP
35271311
种属内
PSMC4 P43686 PSMC6 Homo sapiens P62333
Solution Sedimentation
19490896
种属内
PSMC4 P43686 PSMC5 Homo sapiens P62195
Y2H Prey Pooling
32296183
种属内
PSMC4 P43686 PSMC5 Homo sapiens P62195
Anti Tag CoIP
35271311
种属内
PSMC4 P43686 PSMC5 Homo sapiens P62195
Anti Bait CoIP
17353931
种属内
PSMC4 P43686 PSMC5 Homo sapiens P62195
Y2H Pooling
16189514
种属内
PSMC4 P43686 PSMC5 Homo sapiens P62195
Validated Y2H
32296183
种属内
PSMC4 P43686 PSMC5 Homo sapiens P62195
Y2H Array
32296183
种属内
PSMC4 P43686 PSMC5 Homo sapiens P62195
Anti Tag CoIP
19490896
种属内
PSMC4 P43686 PSMC5 Homo sapiens P62195
Y2H Array
29892012
种属内
PSMC4 P43686 PSMD4 Homo sapiens P55036
Anti Tag CoIP
33961781
种属内
PSMC4 P43686 PSMD10 Homo sapiens O75832
Validated Y2H
25416956
种属内
PSMC4 P43686 PSMD10 Homo sapiens O75832
Anti Tag CoIP
24338975
种属内
PSMC4 P43686 PSMD10 Homo sapiens O75832
Y2H Pooling
16189514
种属内
PSMC4 P43686 PSMD10 Homo sapiens O75832
Anti Tag CoIP
12525503
种属内
PSMC4 P43686 PSMD10 Homo sapiens O75832
Y2H Array
25416956
种属内
PSMC4 P43686 PSMD10 Homo sapiens O75832
Anti Tag CoIP
33961781
种属内
PSMC4 P43686 PSMD10 Homo sapiens O75832
Y2H Prey Pooling
32296183
种属内
PSMC4 P43686 PSMD10 Homo sapiens O75832
Y2H Array
32296183
种属内
PSMC4 P43686 PSMD10 Homo sapiens O75832
Y2H Prey Pooling
25416956
种属内
PSMC4 P43686 PSMD10 Homo sapiens O75832
Y2H
12525503
种属内
PSMC4 P43686 PSMD10 Homo sapiens O75832
Anti Tag CoIP
35271311
种属内
PSMC4 P43686 PSMD10 Homo sapiens O75832
Anti Bait CoIP
17353931
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Episodic Ataxia, Type 2

Episodic Ataxia Type 2

EA2

Apca

Capa

Cerebellopathy, Hereditary Paroxysmal

Acetazolamide-Responsive Hereditary Paroxysmal Cerebellar Ataxia

Cerebellar Ataxia, Paroxysmal, Acetazolamide-Responsive

Episodic Ataxia With Nystagmus

Ataxia, Episodic, With Nystagmus

Episodic Ataxia, Nystagmus-Associated

Ataxia, Familial Paroxysmal

Acetazolamide-Responsive Episodic Ataxia Syndrome

Acetazolamide-Responsive, Hereditary, Paroxysmal, Cerebellar Ataxia

Ataxia, Familial, Paroxysmal

Nystagmus-Associated Episodic Ataxia

Familial Paroxysmal Ataxia

Episodic Ataxia 2

Ea-2

Episodic Ataxia Nystagmus-Associated

Hereditary Paroxysmal Cerebellopathy

Ataxia, Episodic, Type 2
Timothy Syndrome

Long Qt Syndrome With Syndactyly

TS

Lqt8

Long Qt Syndrome 8

Long Qt Syndrome Type 8

Long Qt Syndrome-Syndactyly Syndrome
Myotonia
Erythromelalgia

Primary Erythromelalgia

Erythermalgia

Primary Erythermalgia

Mitchell Disease

Familial Erythromelalgia
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome

Sudden Unexplained Nocturnal Death Syndrome

Bangungut

Brugada Type Idiopathic Ventricular Fibrillation

Pokkuri Death Syndrome

Sunds

Idiopathic Ventricular Fibrillation, Brugada Type

Sudden Unexplained Death

Dream Disease

Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome

Sudden Unexplained Death Syndrome

Suds

Sunds - [Sudden Unexplained Nocturnal Death Syndrome]
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11314 PSMC4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PSMC4 VGNC VGNC:33458
Canis familiaris PSMC4 VGNC VGNC:45104
Felis catus PSMC4 VGNC VGNC:69115
Rattus norvegicus PSMC4 RGD RGD:621102
Mus musculus PSMC4 MGD MGI:1346093
Macaca mulatta PSMC4 VGNC VGNC:76448
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