SKA1 - spindle and kinetochore associated complex subunit 1 Gene

中文名称：纺锤体和着丝粒相关复合亚基 1

种属: Homo sapiens

同用名: C18orf24

基因 ID: 220134 | 基因类型: protein coding

关于 SKA1

Cytogenetic location: 18q21.1 Genomic coordinates (GRCh38): 18:50,375,046-50,394,168 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele and 97 orthologues. Biased expression in bone marrow (RPKM 4.0), testis (RPKM 3.1) and 12 other tissues.

功能概要

启用微管结合活动。参与多个过程，包括染色体分离；有丝分裂细胞周期；和调节微管聚合或解聚。位于纺锤体微管中。外着丝粒的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables microtubule binding activity. Involved in several processes, including chromosome segregation; mitotic cell cycle; and regulation of microtubule polymerization or depolymerization. Located in spindle microtubule. Part of outer kinetochore. [provided by Alliance of Genome Resources, Apr 2022]

SKA1 基因产物(2)

mRNA	Protein	Name
NM_001039535.3	NP_001034624.1	spindle and kinetochore-associated protein 1
NM_145060.4	NP_659497.1	spindle and kinetochore-associated protein 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables microtubule binding	IDA IDA: 通过直接分析推断	19289083	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in attachment of mitotic spindle microtubules to kinetochore	IDA IDA: 通过直接分析推断	29487209	GOA
involved in attachment of mitotic spindle microtubules to kinetochore	IMP IMP: 通过突变表型推断	36592928	GOA
involved in metaphase chromosome alignment	IMP IMP: 通过突变表型推断	22371557	GOA
involved in mitotic cell cycle	IMP IMP: 通过突变表型推断	19289083	GOA
involved in mitotic metaphase chromosome alignment	IMP IMP: 通过突变表型推断	28495837	GOA
involved in mitotic sister chromatid segregation	IMP IMP: 通过突变表型推断	17093495	GOA
involved in negative regulation of mitotic spindle assembly checkpoint signaling	IMP IMP: 通过突变表型推断	26981768	GOA
involved in positive regulation of microtubule polymerization	IDA IDA: 通过直接分析推断	27225956	GOA
involved in regulation of microtubule polymerization or depolymerization	IDA IDA: 通过直接分析推断	19289083	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of SKA complex	IDA IDA: 通过直接分析推断	31804178	GOA
located in centrosome	IDA IDA: 通过直接分析推断	26981768	GOA
located in kinetochore	IDA IDA: 通过直接分析推断	24413531	GOA
located in kinetochore	IPI IPI: 通过物理相互作用推断	21633384	GOA
located in mitotic spindle	IDA IDA: 通过直接分析推断	26981768	GOA
located in mitotic spindle microtubule	IDA IDA: 通过直接分析推断	27225956	GOA
part of outer kinetochore	IDA IDA: 通过直接分析推断	17093495	GOA
located in spindle microtubule	IDA IDA: 通过直接分析推断	17093495	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SKA1 蛋白结构

SKA1

0
100
200
255 a.a.

蛋白主名

其他名称

spindle and kinetochore-associated protein 1

spindle and KT (kinetochore) associated 1

SKA1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	SKA1	Q96BD8	CCDC196	Homo sapiens	A0A1B0GWI1	Y2H Array	32296183
Intra	SKA1	Q96BD8	CCDC196	Homo sapiens	A0A1B0GWI1	Y2H Prey Pooling	32296183
Intra	SKA1	Q96BD8	SKA3	Homo sapiens	Q8IX90	Y2H Array	32296183
Intra	SKA1	Q96BD8	SKA3	Homo sapiens	Q8IX90	Anti Tag CoIP	26496610
Intra	SKA1	Q96BD8	SKA3	Homo sapiens	Q8IX90	Y2H Array	31515488
Intra	SKA1	Q96BD8	SKA3	Homo sapiens	Q8IX90	GMS	19360002
Intra	SKA1	Q96BD8	SKA3	Homo sapiens	Q8IX90	Y2H Prey Pooling	32296183
Intra	SKA1	Q96BD8	SKA2	Homo sapiens	Q8WVK7	Anti Bait CoIP	17093495
Intra	SKA1	Q96BD8	SKA2	Homo sapiens	Q8WVK7	Y2H	17093495
Intra	SKA1	Q96BD8	SKA2	Homo sapiens	Q8WVK7	Imaging	17093495
Intra	SKA1	Q96BD8	SKA2	Homo sapiens	Q8WVK7	GMS	19360002
Intra	SKA1	Q96BD8	SKA2	Homo sapiens	Q8WVK7	Anti Tag CoIP	26496610
Intra	SKA1	Q96BD8	FAM9C	Homo sapiens	Q8IZT9	Y2H Prey Pooling	32296183
Intra	SKA1	Q96BD8	FAM9C	Homo sapiens	Q8IZT9	Y2H Array	32296183
Intra	SKA1	Q96BD8	SNAPIN	Homo sapiens	O95295	Y2H Prey Pooling	32296183
Intra	SKA1	Q96BD8	SNAPIN	Homo sapiens	O95295	Y2H Array	32296183
Intra	SKA1	Q96BD8	PSMC5	Homo sapiens	P62195	Anti Tag CoIP	26496610
Intra	SKA1	Q96BD8	BLOC1S6	Homo sapiens	Q9UL45	Validated Y2H	25416956
Intra	SKA1	Q96BD8	BLOC1S6	Homo sapiens	Q9UL45	Validated Y2H	32296183
Intra	SKA1	Q96BD8	SYCE1	Homo sapiens	Q8N0S2	Validated Y2H	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Serous Labyrinthitis

Acute Serous Labyrinthitis

Ovary Serous Adenocarcinoma

Malignant Ovarian Serous Tumor

Serous Carcinoma Of Ovary

Acute Poststreptococcal Glomerulonephritis

Post-Streptococcal Glomerulonephritis

Acute Post-Streptococcal Glomerulonephritis

Filippi Syndrome

Scott Craniodigital Syndrome With Mental Retardation	Type 1 Syndactyly-Microcephaly-Intellectual Disability Syndrome
FLPIS	Scott Bryant Graham Syndrome
Craniodigital-Intellectual Disability Syndrome	Scott Craniodigital Syndrome
Scott-Bryant-Graham Syndrome	Syndactyly, Type I, With Microcephaly And Mental Retardation
Syndactyly Type I With Microcephaly And Intellectual Disability	Unusual Facial Appearance, Microcephaly, Growth And Intellectual Disability And Syndactyly
Craniodigital Syndrome With Intellectual Disability	Craniodigital Syndrome-Intellectual Disability Syndrome
Craniodigital Syndrome-Intellectual Disability, Scott Type	Intellectual Disability-Craniodigital Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12964	SKA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	SKA1	RGD	RGD:1310784
Bos taurus	SKA1	VGNC	VGNC:34643
Canis familiaris	SKA1	VGNC	VGNC:46193
Felis catus	SKA1	VGNC	VGNC:65167
Mus musculus	SKA1	MGD	MGI:1913718
Macaca mulatta	SKA1	VGNC	VGNC:77577

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SKA1 - spindle and kinetochore associated complex subunit 1 Gene

关于 SKA1

功能概要

SKA1 基因产物(2)

SKA1 蛋白结构

SKA1 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

SKA1 - spindle and kinetochore associated complex subunit 1 Gene

关于 SKA1

功能概要

SKA1 基因产物(2)

SKA1 蛋白结构

SKA1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z