2. Gene
  3. SKA2 - spindle and kinetochore associated complex subunit 2 Gene

SKA2 - spindle and kinetochore associated complex subunit 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：纺锤体和着丝粒相关复合亚基 2

种属: Homo sapiens

同用名: FAM33A

基因 ID: 348235 | 基因类型: protein coding

关于 SKA2

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:59,109,857-59,155,186 (from NCBI)

This gene has 10 transcripts (splice variants) and 230 orthologues. Ubiquitous expression in brain (RPKM 9.5), thyroid (RPKM 8.8) and 25 other tissues.

功能概要

启用微管结合活动。参与多个过程，包括染色体分离；有丝分裂细胞周期；和调节微管聚合或解聚。位于纺锤体微管中。外着丝粒的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables microtubule binding activity. Involved in several processes, including chromosome segregation; mitotic cell cycle; and regulation of microtubule polymerization or depolymerization. Located in spindle microtubule. Part of outer kinetochore. [provided by Alliance of Genome Resources, Apr 2022]

SKA2 基因产物(3)

mRNA Protein Name
NM_001100595.2 NP_001094065.1 spindle and kinetochore-associated protein 2 isoform 2
NM_001330399.2 NP_001317328.1 spindle and kinetochore-associated protein 2 isoform 3
NM_182620.4 NP_872426.1 spindle and kinetochore-associated protein 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables microtubule binding IDA
IDA: 通过直接分析推断
19289083 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17093495 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in attachment of mitotic spindle microtubules to kinetochore IDA
IDA: 通过直接分析推断
29487209 GOA
involved in mitotic metaphase chromosome alignment IPI
IPI: 通过物理相互作用推断
28495837 GOA
involved in mitotic sister chromatid segregation IMP
IMP: 通过突变表型推断
17093495 GOA
involved in regulation of microtubule polymerization or depolymerization IDA
IDA: 通过直接分析推断
19289083 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of SKA complex IDA
IDA: 通过直接分析推断
31804178 GOA
located in kinetochore IPI
IPI: 通过物理相互作用推断
21633384 GOA
part of outer kinetochore IDA
IDA: 通过直接分析推断
17093495 GOA
located in spindle microtubule IDA
IDA: 通过直接分析推断
17093495 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

spindle and kinetochore-associated protein 2

family with sequence similarity 33, member A

SKA2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SKA2 Q8WVK7 IFT57 Homo sapiens Q9NWB7
Validated Y2H
32296183
种属内
SKA2 Q8WVK7 SKA1 Homo sapiens Q96BD8
Anti Tag CoIP
33961781
种属内
SKA2 Q8WVK7 SKA1 Homo sapiens Q96BD8
Anti Bait CoIP
17093495
种属内
SKA2 Q8WVK7 SKA1 Homo sapiens Q96BD8
Pull Down
19360002
种属内
SKA2 Q8WVK7 SKA1 Homo sapiens Q96BD8
Anti Tag CoIP
17093495
种属内
SKA2 Q8WVK7 SKA1 Homo sapiens Q96BD8
Y2H
17093495
种属内
SKA2 Q8WVK7 SKA1 Homo sapiens Q96BD8
Anti Bait CoIP
19360002
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Mulibrey Nanism

MUL

Muscle-Liver-Brain-Eye Nanism

Pericardial Constriction And Growth Failure

Perheentupa Syndrome

Mulibrey Growth Disorder

Mulibrey Nanism Syndrome

Pericardial Constriction With Growth Failure

Nanism Mulibrey
Acute Poststreptococcal Glomerulonephritis

Post-Streptococcal Glomerulonephritis

Acute Post-Streptococcal Glomerulonephritis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12965 SKA2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus SKA2 VGNC VGNC:34644
Canis familiaris SKA2 VGNC VGNC:46194
Macaca mulatta SKA2 VGNC VGNC:104651
Mus musculus SKA2 MGD MGI:1913390
Rattus norvegicus SKA2 RGD RGD:1307084
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