2. Gene
  3. SKA3 - spindle and kinetochore associated complex subunit 3 Gene

SKA3 - spindle and kinetochore associated complex subunit 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：纺锤体和着丝粒相关复合亚基 3

种属: Homo sapiens

同用名: RAMA1; C13orf3

基因 ID: 221150 | 基因类型: protein coding

关于 SKA3

Cytogenetic location: 13q12.11 Genomic coordinates (GRCh38): 13:21,153,595-21,176,552 (from NCBI)

This gene has 7 transcripts (splice variants) and 195 orthologues. Biased expression in testis (RPKM 4.8), bone marrow (RPKM 3.0) and 13 other tissues.

功能概要

该基因编码纺锤体和着丝粒相关蛋白复合物的一个成分，该复合物在有丝分裂期间调节微管与着丝粒的附着。编码的蛋白质定位于外部着丝粒，可能是正常染色体分离和细胞分裂所必需的。可变剪接导致多个转录本变体。[RefSeq 提供，2009 年 10 月]

This gene encodes a component of the spindle and kinetochore-associated protein complex that regulates microtubule attachment to the kinetochores during mitosis. The encoded protein localizes to the outer kinetechore and may be required for normal chromosome segregation and cell division. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

SKA3 基因产物(2)

mRNA Protein Name
NM_001166017.2 NP_001159489.1 spindle and kinetochore-associated protein 3 isoform 2
NM_145061.6 NP_659498.4 spindle and kinetochore-associated protein 3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables microtubule binding IDA
IDA: 通过直接分析推断
29487209 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19289083 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in attachment of mitotic spindle microtubules to kinetochore IDA
IDA: 通过直接分析推断
29487209 GOA
involved in attachment of mitotic spindle microtubules to kinetochore IMP
IMP: 通过突变表型推断
28479321 GOA
involved in metaphase chromosome alignment IMP
IMP: 通过突变表型推断
22371557 GOA
involved in mitotic metaphase chromosome alignment IPI
IPI: 通过物理相互作用推断
28495837 GOA
involved in mitotic sister chromatid segregation IMP
IMP: 通过突变表型推断
19289083 GOA
involved in negative regulation of mitotic spindle assembly checkpoint signaling IMP
IMP: 通过突变表型推断
19646878 GOA
involved in regulation of microtubule polymerization or depolymerization IDA
IDA: 通过直接分析推断
19289083 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of SKA complex IDA
IDA: 通过直接分析推断
31804178 GOA
located in centrosome IDA
IDA: 通过直接分析推断
19646878 GOA
located in kinetochore IDA
IDA: 通过直接分析推断
20813266 GOA
located in kinetochore IPI
IPI: 通过物理相互作用推断
21633384 GOA
located in mitotic spindle IDA
IDA: 通过直接分析推断
19646878 GOA
part of outer kinetochore IDA
IDA: 通过直接分析推断
19289083 GOA
located in spindle microtubule IDA
IDA: 通过直接分析推断
19289083 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

spindle and kinetochore-associated protein 3

SKA3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SKA3 Q8IX90 SKA1 Homo sapiens Q96BD8
Anti Tag CoIP
33961781
Intra SKA3 Q8IX90 SKA1 Homo sapiens Q96BD8
Anti Tag CoIP
28514442
Intra SKA3 Q8IX90 SKA1 Homo sapiens Q96BD8
Validated Y2H
32296183
Intra SKA3 Q8IX90 SKA1 Homo sapiens Q96BD8
Anti Tag CoIP
26496610
Intra SKA3 Q8IX90 SKA1 Homo sapiens Q96BD8
IF
19360002
Intra SKA3 Q8IX90 SKA1 Homo sapiens Q96BD8
Anti Tag CoIP
19360002
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Uterine Adnexa Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12966 SKA3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus SKA3 VGNC VGNC:65168
Rattus norvegicus SKA3 RGD RGD:1307201
Canis familiaris SKA3 VGNC VGNC:46195
Bos taurus SKA3 VGNC VGNC:34645
Macaca mulatta SKA3 VGNC VGNC:77525
Mus musculus SKA3 MGD MGI:3041235
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z