SYCE1 - synaptonemal complex central element protein 1 Gene

中文名称：联会复合中心元件蛋白 1

种属: Homo sapiens

同用名: CT76; POF12; SPGF15; C10orf94

基因 ID: 93426 | 基因类型: protein coding

关于 SYCE1

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:133,553,899-133,568,291 (from NCBI)

This gene has 5 transcripts (splice variants), 117 orthologues, 1 paralogue and is associated with 4 phenotypes. Biased expression in testis (RPKM 31.6), placenta (RPKM 4.3) and 1 other tissue.

功能概要

该基因编码联会复合体的一个成员，该复合体在减数分裂的前期 I 期间连接同源染色体。该复合体的三重结构在后生动物中高度保守。它由两个横向元件和由横向元件和中心元件形成的中心区域组成。由该基因编码的蛋白质定位于中心元件，是突触的启动和延长所必需的。该基因的等位基因变异与卵巢早衰和生精失败有关。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 11 月]

This gene encodes a member of the synaptonemal complex, which links homologous chromosomes during prophase I of meiosis. The tripartite structure of the complex is highly conserved amongst metazoans. It consists of two lateral elements and a central region formed by transverse elements and a central element. The protein encoded by this gene localizes to the central element and is required for initiation and elongation of the synapsis. Allelic variants of this gene have been associated with premature ovarian failure and spermatogenic failure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

SYCE1 基因产物(3)

mRNA	Protein	Name
NM_001143763.2	NP_001137235.1	synaptonemal complex central element protein 1 isoform 3
NM_001143764.3	NP_001137236.1	synaptonemal complex central element protein 1 isoform 4
NM_130784.4	NP_570140.1	synaptonemal complex central element protein 1 isoform 1

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SYCE1 蛋白结构

SYCE1

0
100
200
300
351 a.a.

蛋白主名

其他名称

synaptonemal complex central element protein 1

cancer/testis antigen 76

SYCE1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	SYCE1	Q8N0S2	CCDC102B	Homo sapiens	Q68D86	Y2H Prey Pooling	25416956
Intra	SYCE1	Q8N0S2	CCDC102B	Homo sapiens	Q68D86	Validated Y2H	25416956
Intra	SYCE1	Q8N0S2	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	32296183
Intra	SYCE1	Q8N0S2	TPM3	Homo sapiens	Q5VU62	Validated Y2H	25416956
Intra	SYCE1	Q8N0S2	TPM1	Homo sapiens	P09493-5	Y2H Prey Pooling	25416956
Intra	SYCE1	Q8N0S2	IQUB	Homo sapiens	Q8NA54	Y2H Array	25416956
Intra	SYCE1	Q8N0S2	BFSP2	Homo sapiens	Q13515	Y2H Prey Pooling	25416956
Intra	SYCE1	Q8N0S2	BFSP2	Homo sapiens	Q13515	Validated Y2H	25416956
Intra	SYCE1	Q8N0S2	EDRF1	Homo sapiens	Q3B7T1-5	Validated Y2H	25416956
Intra	SYCE1	Q8N0S2	CBY2	Homo sapiens	Q8NA61-2	BFG-2H	27107012
Intra	SYCE1	Q8N0S2	CBY2	Homo sapiens	Q8NA61-2	Validated Y2H	32296183
Intra	SYCE1	Q8N0S2	SPATC1L	Homo sapiens	Q9H0A9-2	Validated Y2H	32296183
Intra	SYCE1	Q8N0S2	KIFC3	Homo sapiens	Q9BVG8	Validated Y2H	25416956
Intra	SYCE1	Q8N0S2	KIFC3	Homo sapiens	Q9BVG8	Y2H Array	25416956
Intra	SYCE1	Q8N0S2	SSX2	Homo sapiens	Q16385	Y2H Array	25416956
Intra	SYCE1	Q8N0S2	SSX2	Homo sapiens	Q16385	Validated Y2H	25416956
Intra	SYCE1	Q8N0S2	RBCK1	Homo sapiens	Q9BYM8	Y2H Prey Pooling	25416956
Intra	SYCE1	Q8N0S2	HAUS1	Homo sapiens	Q96CS2	Validated Y2H	25416956
Intra	SYCE1	Q8N0S2	ZNF124	Homo sapiens	Q15973	Y2H Array	25416956
Intra	SYCE1	Q8N0S2	TXN2	Homo sapiens	Q99757	Validated Y2H	32296183
Intra	SYCE1	Q8N0S2	TSG101	Homo sapiens	Q99816	Y2H Prey Pooling	25416956
Intra	SYCE1	Q8N0S2	TSG101	Homo sapiens	Q99816	Validated Y2H	25416956
Intra	SYCE1	Q8N0S2	TSG101	Homo sapiens	Q99816	Validated Y2H	32296183
Intra	SYCE1	Q8N0S2	TSG101	Homo sapiens	Q99816	Y2H Array	25416956
Intra	SYCE1	Q8N0S2	TPM1	Homo sapiens	P09493	Validated Y2H	25416956
Intra	SYCE1	Q8N0S2	TPM1	Homo sapiens	P09493	Anti Tag CoIP	33961781
Intra	SYCE1	Q8N0S2	TPM3	Homo sapiens	P06753	Y2H Array	25416956
Intra	SYCE1	Q8N0S2	TPM3	Homo sapiens	P06753	Y2H Prey Pooling	25416956
Intra	SYCE1	Q8N0S2	TRAF1	Homo sapiens	Q13077	Y2H Array	25416956
Intra	SYCE1	Q8N0S2	TRAF1	Homo sapiens	Q13077	Validated Y2H	25416956
Intra	SYCE1	Q8N0S2	KAT5	Homo sapiens	Q92993	Validated Y2H	32296183
Intra	SYCE1	Q8N0S2	SMARCE1	Homo sapiens	Q969G3	Validated Y2H	25416956
Intra	SYCE1	Q8N0S2	SMARCE1	Homo sapiens	Q969G3	Y2H Array	25416956
Intra	SYCE1	Q8N0S2	SMARCE1	Homo sapiens	Q969G3	Y2H Prey Pooling	25416956
Intra	SYCE1	Q8N0S2	WASHC3	Homo sapiens	Q9Y3C0	Y2H Array	31515488
Intra	SYCE1	Q8N0S2	WASHC3	Homo sapiens	Q9Y3C0	Y2H Prey Pooling	25416956
Intra	SYCE1	Q8N0S2	HMG20B	Homo sapiens	Q9P0W2	Y2H Array	25416956
Intra	SYCE1	Q8N0S2	FAM161A	Homo sapiens	Q3B820	Y2H Prey Pooling	25416956
Intra	SYCE1	Q8N0S2	FAM161B	Homo sapiens	Q96MY7	MAPPIT	32296183
Intra	SYCE1	Q8N0S2	FAM161B	Homo sapiens	Q96MY7	Validated Y2H	32296183
Intra	SYCE1	Q8N0S2	TRIM41	Homo sapiens	Q8WV44	Validated Y2H	32296183
Intra	SYCE1	Q8N0S2	HSPB7	Homo sapiens	Q9UBY9	Y2H Array	25416956
Intra	SYCE1	Q8N0S2	HSPB7	Homo sapiens	Q9UBY9	Validated Y2H	25416956
Intra	SYCE1	Q8N0S2	CINP	Homo sapiens	Q9BW66	Y2H Prey Pooling	25416956
Intra	SYCE1	Q8N0S2	CINP	Homo sapiens	Q9BW66	Validated Y2H	25416956
Intra	SYCE1	Q8N0S2	CINP	Homo sapiens	Q9BW66	Y2H Array	25416956
Intra	SYCE1	Q8N0S2	CYTH3	Homo sapiens	O43739	Y2H Array	25416956
Intra	SYCE1	Q8N0S2	CYTH3	Homo sapiens	O43739	Anti Tag CoIP	33961781
Intra	SYCE1	Q8N0S2	CYTH3	Homo sapiens	O43739	Y2H Prey Pooling	25416956
Intra	SYCE1	Q8N0S2	CBY2	Homo sapiens	Q8NA61	Y2H Array	25416956
Intra	SYCE1	Q8N0S2	SKA1	Homo sapiens	Q96BD8	Y2H Array	25416956
Intra	SYCE1	Q8N0S2	SKA1	Homo sapiens	Q96BD8	Y2H Prey Pooling	25416956
Intra	SYCE1	Q8N0S2	VPS25	Homo sapiens	Q9BRG1	Validated Y2H	32296183
Intra	SYCE1	Q8N0S2	EXOC8	Homo sapiens	Q8IYI6	Y2H Prey Pooling	32296183
Intra	SYCE1	Q8N0S2	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	32296183
Intra	SYCE1	Q8N0S2	BEX2	Homo sapiens	Q9BXY8	Validated Y2H	32296183
Intra	SYCE1	Q8N0S2	HOOK1	Homo sapiens	Q9UJC3	Y2H Array	25416956
Intra	SYCE1	Q8N0S2	HOOK1	Homo sapiens	Q9UJC3	Anti Tag CoIP	33961781
Intra	SYCE1	Q8N0S2	HOOK1	Homo sapiens	Q9UJC3	Y2H Prey Pooling	25416956
Intra	SYCE1	Q8N0S2	MRFAP1L1	Homo sapiens	Q96HT8	Y2H Prey Pooling	25416956
Intra	SYCE1	Q8N0S2	MRFAP1L1	Homo sapiens	Q96HT8	Y2H Array	25416956
Intra	SYCE1	Q8N0S2	ALOX5	Homo sapiens	P09917	Y2H Prey Pooling	25416956
Intra	SYCE1	Q8N0S2	STX19	Homo sapiens	Q8N4C7	Y2H Prey Pooling	25416956
Intra	SYCE1	Q8N0S2	STX19	Homo sapiens	Q8N4C7	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Spermatogenic Failure 15

SPGF15

Spermatogenic Failure, 15

Premature Ovarian Failure 12

POF12

Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

46 Xx Gonadal Dysgenesis

Ovarian Dysgenesis	Gonadal Dysgenesis, 46,Xx
Dysgenesis, Ovarian

Spermatogenic Failure 10

SPGF10

Spermatogenic Failure With Defective Sperm Annulus

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Spermatogenic Failure 5

Male Infertility With Large-Headed, Multiflagellar, Polyploid Spermatozoa	Infertility Associated With Multi-Tailed Spermatozoa And Excessive Dna
SPGF5	Macrocephalic Sperm Head Syndrome
Male Infertility Due To Macrozoospermia	Infertility Associated With Multitailed Spermatozoa And Excessive Dna
Macrozoospermia	Male Infertility Due To Large-Headed Multiflagellar Polyploid Spermatozoa
Infertility Associated With Multi-Tailed Spermatozoa And Excessive Deoxyribonucleic Acid	Large-Headed Multiflagellar Polyploid Spermatozoa
Male Infertility With Large-Headed Multiflagellar Polyploid Spermatozoa

Spermatogenic Failure, X-Linked, 1

Sertoli Cell-Only Syndrome	Germinal Cell Aplasia
Del Castillo Syndrome	SPGFX1
X-Linked Spermatogenic Failure 1	Congenital Absence Of Germinal Epithelium Of Testes

Multiple Synostoses Syndrome

Symphalangism-Brachydactyly Syndrome	Deafness-Hermann Type Symphalangism Syndrome
Facio-Audio-Symphalangism	Hearing Loss-Hermann Type Symphalangism Syndrome
Wl Syndrome	Multiple Synostosis Syndrome

Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome

Icf Syndrome	Immunodeficiency Syndrome, Variable
Ciid	Centromeric Instability, Immunodeficiency Syndrome
Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16	Icf

Spermatogenic Failure, Y-Linked, 2

SPGFY2	Spermatogenic Failure, Nonobstructive, Y-Linked
Y-Linked Spermatogenic Failure 2	Azoospermia, Nonobstructive, Y-Linked
Oligozoospermia, Nonobstructive, Y-Linked	Oligospermia, Nonobstructive, Y-Linked
Spermatogenic Arrest, Y-Linked	Nonobstructive Y-Linked Spermatogenic Failure
Spermatogenic Failure Y-Linked 2	Azoospermia Non-Obstructive Y-Linked
Non-Obstructive Azoospermia And Infertility	Oligospermia Non-Obstructive Y-Linked
Oligozoospermia Non-Obstructive Y-Linked	Spermatogenic Arrest Y-Linked
Spermatogenic Failure Nonobstructive Y-Linked

Perrault Syndrome

Gonadal Dysgenesis, Xx Type, With Deafness	Ovarian Dysgenesis With Sensorineural Deafness
Gonadal Dysgenesis, Xx Type	Gonadal Dysgenesis With Auditory Dysfunction, Autosomal Recessive Inheritance
Gonadal Dysgenesis With Sensorineural Deafness, Autosomal Recessive Inheritance	Xx Gonodal Dysgenesis-Deafness Syndrome
Xx Gonodal Dysgenesis-Hearing Loss Syndrome	Gonadal Dysgenesis Xx Type Deafness

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14068	SYCE1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	SYCE1	VGNC	VGNC:35504
Rattus norvegicus	SYCE1	RGD	RGD:1559853
Felis catus	SYCE1	VGNC	VGNC:97651
Canis familiaris	SYCE1	VGNC	VGNC:47014
Mus musculus	SYCE1	MGD	MGI:1921325

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