VPS25 - vacuolar protein sorting 25 homolog Gene

中文名称：液泡蛋白分选 25 同系物

种属: Homo sapiens

同用名: DERP9; EAP20; FAP20

基因 ID: 84313 | 基因类型: protein coding

关于 VPS25

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:42,773,449-42,779,599 (from NCBI)

This gene has 6 transcripts (splice variants) and 186 orthologues. Ubiquitous expression in esophagus (RPKM 14.2), colon (RPKM 12.6) and 25 other tissues.

功能概要

该基因编码的蛋白质是转运 II (ESCRT-II) 所需的内体分选复合物的一个亚基。这种蛋白质复合物在内吞过程中对泛素化膜蛋白进行分类。该基因的假基因存在于 1 号染色体上。[RefSeq 提供，2013 年 7 月]

This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A pseudogene of this gene is present on chromosome 1. [provided by RefSeq, Jul 2013]

VPS25 基因产物(1)

mRNA	Protein	Name
NM_032353.4	NP_115729.1	vacuolar protein-sorting-associated protein 25

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	14505570	GOA
enables protein homodimerization activity	IPI IPI: 通过物理相互作用推断	14519844	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of epidermal growth factor-activated receptor activity	IMP IMP: 通过突变表型推断	16973552	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of ESCRT II complex	IDA IDA: 通过直接分析推断	16973552	GOA
part of ESCRT II complex	IPI IPI: 通过物理相互作用推断	18539118	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	16973552	GOA
located in cytosol	IDA IDA: 通过直接分析推断	17010938	GOA
located in endosome membrane	IDA IDA: 通过直接分析推断	16371348	GOA
located in nucleus	IDA IDA: 通过直接分析推断	16371348	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

VPS25 蛋白结构

ESCRT-II

0
100
176 a.a.

蛋白主名

其他名称

vacuolar protein-sorting-associated protein 25

ELL-associated protein of 20 kDa

VPS25 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	VPS25	Q9BRG1	CHMP6	Homo sapiens	Q96FZ7	Y2H Prey Pooling	32296183
Intra	VPS25	Q9BRG1	CHMP6	Homo sapiens	Q96FZ7	Y2H	16730941
Intra	VPS25	Q9BRG1	CHMP6	Homo sapiens	Q96FZ7	Y2H Array	32296183
Intra	VPS25	Q9BRG1	ASPG	Homo sapiens	Q86U10	Y2H Prey Pooling	32296183
Intra	VPS25	Q9BRG1	ASPG	Homo sapiens	Q86U10	Y2H Array	32296183
Intra	VPS25	Q9BRG1	SEPTIN14	Homo sapiens	Q6ZU15	Y2H Prey Pooling	32296183
Intra	VPS25	Q9BRG1	SEPTIN14	Homo sapiens	Q6ZU15	Y2H Array	32296183
Intra	VPS25	Q9BRG1	CRLF3	Homo sapiens	Q8IUI8	Y2H Prey Pooling	25416956
Intra	VPS25	Q9BRG1	CRLF3	Homo sapiens	Q8IUI8	Validated Y2H	25416956
Intra	VPS25	Q9BRG1	CRLF3	Homo sapiens	Q8IUI8	Y2H Prey Pooling	32296183
Intra	VPS25	Q9BRG1	CRLF3	Homo sapiens	Q8IUI8	Y2H Array	32296183
Intra	VPS25	Q9BRG1	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	VPS25	Q9BRG1	VPS36	Homo sapiens	Q86VN1	Anti Tag CoIP	33961781
Intra	VPS25	Q9BRG1	VPS36	Homo sapiens	Q86VN1	Y2H Prey Pooling	32296183
Intra	VPS25	Q9BRG1	VPS36	Homo sapiens	Q86VN1	Y2H Array	32296183
Intra	VPS25	Q9BRG1	VPS36	Homo sapiens	Q86VN1	Anti Tag CoIP	35271311
Intra	VPS25	Q9BRG1	SYCE1	Homo sapiens	Q8N0S2	Y2H Prey Pooling	32296183
Intra	VPS25	Q9BRG1	SYCE1	Homo sapiens	Q8N0S2	Y2H Array	32296183
Intra	VPS25	Q9BRG1	B9D2	Homo sapiens	Q9BPU9	Y2H Prey Pooling	32296183
Intra	VPS25	Q9BRG1	B9D2	Homo sapiens	Q9BPU9	Y2H Array	32296183
Intra	VPS25	Q9BRG1	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	VPS25	Q9BRG1	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	VPS25	Q9BRG1	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	VPS25	Q9BRG1	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	VPS25	Q9BRG1	BEND5	Homo sapiens	Q7L4P6	Validated Y2H	25416956
Intra	VPS25	Q9BRG1	TADA2A	Homo sapiens	O75478	Y2H Array	32296183
Intra	VPS25	Q9BRG1	TADA2A	Homo sapiens	O75478	Y2H Prey Pooling	32296183
Intra	VPS25	Q9BRG1	SDCBP2	Homo sapiens	Q9H190	Validated Y2H	32296183
Intra	VPS25	Q9BRG1	SDCBP2	Homo sapiens	Q9H190	Y2H Array	32296183
Intra	VPS25	Q9BRG1	SDCBP2	Homo sapiens	Q9H190	Y2H Prey Pooling	32296183
Intra	VPS25	Q9BRG1	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	VPS25	Q9BRG1	SPG21	Homo sapiens	Q9NZD8	Y2H Prey Pooling	32296183
Intra	VPS25	Q9BRG1	SPG21	Homo sapiens	Q9NZD8	Y2H Array	32296183
Intra	VPS25	Q9BRG1	SNF8	Homo sapiens	Q96H20	Anti Tag CoIP	35271311
Intra	VPS25	Q9BRG1	SNF8	Homo sapiens	Q96H20	Y2H	21516116
Intra	VPS25	Q9BRG1	SNF8	Homo sapiens	Q96H20	Y2H Array	31515488
Intra	VPS25	Q9BRG1	SNF8	Homo sapiens	Q96H20	Y2H Prey Pooling	25416956
Intra	VPS25	Q9BRG1	SNF8	Homo sapiens	Q96H20	Validated Y2H	25416956
Intra	VPS25	Q9BRG1	SNF8	Homo sapiens	Q96H20	Y2H Prey Pooling	32296183
Intra	VPS25	Q9BRG1	SNF8	Homo sapiens	Q96H20	Y2H Array	32296183
Intra	VPS25	Q9BRG1	SNF8	Homo sapiens	Q96H20	Y2H Array	25416956
Intra	VPS25	Q9BRG1	SNF8	Homo sapiens	Q96H20	Anti Tag CoIP	33961781
Intra	VPS25	Q9BRG1	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	VPS25	Q9BRG1	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	VPS25	Q9BRG1	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	VPS25	Q9BRG1	BPIFA1	Homo sapiens	Q9NP55	Validated Y2H	32296183
Intra	VPS25	Q9BRG1	BPIFA1	Homo sapiens	Q9NP55	Y2H Array	32296183
Intra	VPS25	Q9BRG1	BPIFA1	Homo sapiens	Q9NP55	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7

Ftd3	Frontotemporal Dementia, Chromosome 3-Linked
Amyotrophic Lateral Sclerosis, Chmp2b-Related	Chromosome 3-Linked Frontotemporal Dementia
FTDALS7	Chmp2b-Related Frontotemporal Dementia
Amyotrophic Lateral Sclerosis 17, Formerly	Als17, Formerly
Amyotrophic Lateral Sclerosis Type 17	Dtm1
Ftd-3	Ftd-Chmp2b
Als17	Amyotrophic Lateral Sclerosis 17
Sclerosis, Lateral, Amyotrophic, Type 17	Dementia, Frontotemporal, Chromosome 3-Linked

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15678	VPS25 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	VPS25	MGD	MGI:106354
Felis catus	VPS25	VGNC	VGNC:99572
Bos taurus	VPS25	VGNC	VGNC:36813
Macaca mulatta	VPS25	VGNC	VGNC:79685
Rattus norvegicus	VPS25	RGD	RGD:1584685

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