2. Gene
  3. BPIFA1 - BPI fold containing family A member 1 Gene

BPIFA1 - BPI fold containing family A member 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 BPI 折叠家族 A 成员 1

种属: Homo sapiens

同用名: LUNX; NASG; PLUNC; SPURT; SPLUNC1; bA49G10.5

基因 ID: 51297 | 基因类型: protein coding

关于 BPIFA1

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:33,235,996-33,243,306 (from NCBI)

This gene has 4 transcripts (splice variants), 113 orthologues and 12 paralogues. Biased expression in lung (RPKM 1.2), urinary bladder (RPKM 0.9) and 2 other tissues.

功能概要

该基因是小鼠 plunc 的人类同系物，与小鼠基因一样，在上呼吸道和鼻咽区域特异性表达。编码的抗菌蛋白显示出对革兰氏阴性菌的抗菌活性。它被认为与上呼吸道刺激物的炎症反应有关，也可能作为检测非小细胞肺癌微转移的潜在分子标记。已检测到由 3' UTR 中的可变剪接产生的多个转录本变体，但只有三个的全长性质是已知的。[RefSeq 提供，2014 年 8 月]

This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The encoded antimicrobial protein displays Antibacterial activity against Gram-negative bacteria. It is thought to be involved in inflammatory responses to irritants in the upper airways and may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung Cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known. [provided by RefSeq, Aug 2014]

BPIFA1 基因产物(3)

mRNA Protein Name
NM_001243193.2 NP_001230122.1 BPI fold-containing family A member 1 precursor
NM_016583.4 NP_057667.1 BPI fold-containing family A member 1 precursor
NM_130852.3 NP_570913.1 BPI fold-containing family A member 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antibacterial humoral response IDA
IDA: 通过直接分析推断
23499554 GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IEP
IEP: 通过表达模式推断
21805676 GOA
involved in defense response to virus IEP
IEP: 通过表达模式推断
21805676 GOA
involved in immune response in nasopharyngeal-associated lymphoid tissue IEP
IEP: 通过表达模式推断
21805676 GOA
involved in innate immune response IDA
IDA: 通过直接分析推断
23499554 GOA
involved in multicellular organismal-level water homeostasis IDA
IDA: 通过直接分析推断
24124190 GOA
involved in negative regulation of single-species biofilm formation in or on host organism IMP
IMP: 通过突变表型推断
23499554 GOA
involved in regulation of sodium ion transmembrane transport IDA
IDA: 通过直接分析推断
24124190 GOA
involved in surfactant homeostasis IDA
IDA: 通过直接分析推断
23499554 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular region IDA
IDA: 通过直接分析推断
11425234 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
21805676 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BPIFA1 蛋白结构

LBP_BPI_CETP

LBP_BPI_CETP: LBP / BPI / CETP family, N-terminal domain (58 - 233)

  • 0
  • 100
  • 200
  • 256 a.a.
蛋白主名 其他名称

BPI fold-containing family A member 1

ligand-binding protein RYA3

BPIFA1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra BPIFA1 Q9NP55 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Array
25416956
Intra BPIFA1 Q9NP55 TCF7L2 Homo sapiens Q9NQB0-10
Validated Y2H
32296183
Intra BPIFA1 Q9NP55 INIP Homo sapiens Q9NRY2
Validated Y2H
32296183
Intra BPIFA1 Q9NP55 MTIF3 Homo sapiens Q9H2K0
Y2H Array
32296183
Intra BPIFA1 Q9NP55 MTIF3 Homo sapiens Q9H2K0
Y2H Prey Pooling
32296183
Intra BPIFA1 Q9NP55 PEF1 Homo sapiens Q9UBV8
Validated Y2H
32296183
Intra BPIFA1 Q9NP55 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32296183
Intra BPIFA1 Q9NP55 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
32296183
Intra BPIFA1 Q9NP55 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra BPIFA1 Q9NP55 RSPH14 Homo sapiens Q9UHP6
Validated Y2H
32296183
Intra BPIFA1 Q9NP55 ALKBH4 Homo sapiens Q9NXW9
Validated Y2H
32296183
Intra BPIFA1 Q9NP55 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra BPIFA1 Q9NP55 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra BPIFA1 Q9NP55 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 BPIFA1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P700957 BPIFA1 Protein, Human Q9NP55-1 (Q20-V256) ≥95%

关联疾病

疾病名称 别名
Nasopharyngeal Carcinoma

Malignant Neoplasm Of Nasopharynx

Npc

Nasopharyngeal Cancer

Nasopharyngeal Carcinoma 1

Nasopharynx Carcinoma

Nasopharyngeal Neoplasms

Npca

Carcinoma Of Nasopharynx

Malignant Nasopharyngeal Tumor

Nasopharynx Cancer

Squamous Cell Carcinoma Of The Nasopharynx

Nasopharyngeal Neoplasm

Cancer Of Nasopharynx
Adenoiditis

Chronic Adenoiditis
Eye Disease

Eye Diseases

Abnormality Of The Eye

Toxoplasma Oculopathy
Chronic Purulent Otitis Media

Chronic Suppurative Otitis Media

Csom - [Chronic Suppurative Otitis Media]
Suppurative Otitis Media

Otitis Media With Effusion - Purulent

Purulent Otitis Media

Otitis Media, Suppurative
Hepatoid Adenocarcinoma
Papillary Cystadenocarcinoma

Cystadenocarcinoma, Papillary
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Lung Disease

Lung Diseases

Disorder Of Lung

Abnormality Of The Lung
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01581 BPIFA1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta BPIFA1 VGNC VGNC:70317
Canis familiaris BPIFA1 VGNC VGNC:38504
Felis catus BPIFA1 VGNC VGNC:60153
Rattus norvegicus BPIFA1 RGD RGD:619818
Mus musculus BPIFA1 MGD MGI:1338036
Bos taurus BPIFA1 VGNC VGNC:26543
Others BPIFA1 NCBI
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