2. Gene
  3. CHMP6 - charged multivesicular body protein 6 Gene

CHMP6 - charged multivesicular body protein 6 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：带电多泡体蛋白 6

种属: Homo sapiens

同用名: VPS20

基因 ID: 79643 | 基因类型: protein coding

关于 CHMP6

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:80,991,841-81,000,133 (from NCBI)

This gene has 4 transcripts (splice variants) and 259 orthologues. Ubiquitous expression in kidney (RPKM 3.0), colon (RPKM 3.0) and 25 other tissues.

功能概要

该基因编码染色质修饰蛋白/带电多泡体蛋白家族的成员。该家族中的蛋白质是 ESCRT-III (运输 III 所需的内体分选复合物) 的一部分，它会降解表面受体，并参与内体的生物合成。[RefSeq 提供，2012 年 3 月]

This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein family. Proteins in this family are part of the ESCRT-III (endosomal sorting complex required for transport III) which degrades surface receptors, and in biosynthesis of endosomes. [provided by RefSeq, Mar 2012]

CHMP6 基因产物(1)

mRNA Protein Name
NM_024591.5 NP_078867.2 charged multivesicular body protein 6
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
14505570 GOA
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
16973552 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in autophagosome maturation IMP
IMP: 通过突变表型推断
17984323 GOA
involved in autophagy IMP
IMP: 通过突变表型推断
17984323 GOA
involved in late endosome to lysosome transport IMP
IMP: 通过突变表型推断
17984323 GOA
involved in midbody abscission IMP
IMP: 通过突变表型推断
20616062 GOA
involved in mitotic metaphase chromosome alignment IMP
IMP: 通过突变表型推断
20616062 GOA
involved in multivesicular body sorting pathway IDA
IDA: 通过直接分析推断
16554368 GOA
involved in negative regulation of epidermal growth factor-activated receptor activity IMP
IMP: 通过突变表型推断
16973552 GOA
involved in nuclear membrane reassembly IMP
IMP: 通过突变表型推断
26040713 GOA
involved in nucleus organization IMP
IMP: 通过突变表型推断
20616062 GOA
involved in plasma membrane repair IDA
IDA: 通过直接分析推断
24482116 GOA
NOT involved in regulation of exosomal secretion IMP
IMP: 通过突变表型推断
22660413 GOA
involved in regulation of mitotic spindle assembly IMP
IMP: 通过突变表型推断
20616062 GOA
involved in regulation of protein catabolic process IMP
IMP: 通过突变表型推断
18606141 GOA
involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IDA
IDA: 通过直接分析推断
17984323 GOA
involved in viral budding from plasma membrane IDA
IDA: 通过直接分析推断
24878737 GOA
involved in viral budding via host ESCRT complex IDA
IDA: 通过直接分析推断
24878737 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of ESCRT III complex IDA
IDA: 通过直接分析推断
24878737 GOA
located in amphisome membrane IDA
IDA: 通过直接分析推断
17984323 GOA
located in autophagosome membrane IDA
IDA: 通过直接分析推断
17984323 GOA
located in endosome membrane IDA
IDA: 通过直接分析推断
16973552 GOA
located in kinetochore IDA
IDA: 通过直接分析推断
26040712 GOA
located in kinetochore microtubule IDA
IDA: 通过直接分析推断
26040712 GOA
located in lysosomal membrane IDA
IDA: 通过直接分析推断
17984323 GOA
located in midbody IDA
IDA: 通过直接分析推断
26040712 GOA
located in multivesicular body membrane IDA
IDA: 通过直接分析推断
16554368 GOA
part of nuclear pore IDA
IDA: 通过直接分析推断
26040713 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
24878737 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CHMP6 蛋白结构

Snf7

Snf7: Snf7 (18 - 177)

  • 0
  • 100
  • 201 a.a.
蛋白主名 其他名称

charged multivesicular body protein 6

chromatin-modifying protein 6

CHMP6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CHMP6 Q96FZ7 DNM2 Homo sapiens P50570-2
Y2H Array
32814053
种属内
CHMP6 Q96FZ7 DNM2 Homo sapiens P50570-2
Validated Y2H
32814053
种属内
CHMP6 Q96FZ7 DNM2 Homo sapiens P50570-2
Y2H Pooling
32814053
种属内
CHMP6 Q96FZ7 TOR1A Homo sapiens O14656-2
Y2H Array
32814053
种属内
CHMP6 Q96FZ7 TOR1A Homo sapiens O14656-2
Y2H Pooling
32814053
种属内
CHMP6 Q96FZ7 TOR1A Homo sapiens O14656-2
Validated Y2H
32814053
种属内
CHMP6 Q96FZ7 SMN1 Homo sapiens Q16637
Y2H Pooling
32814053
种属内
CHMP6 Q96FZ7 SMN1 Homo sapiens Q16637
Validated Y2H
32814053
种属内
CHMP6 Q96FZ7 SMN1 Homo sapiens Q16637
Y2H Array
32814053
种属内
CHMP6 Q96FZ7 VPS25 Homo sapiens Q9BRG1
Validated Y2H
32296183
种属内
CHMP6 Q96FZ7 VPS25 Homo sapiens Q9BRG1
Anti Tag CoIP
33961781
种属内
CHMP6 Q96FZ7 VPS25 Homo sapiens Q9BRG1
Pull Down
16856878
种属间: 跨种属相互作用 种属内: 同种属相互作用

CHMP6 抗体

目录号 产品名 应用 反应物种
HY-P83695 CHMP6 Antibody WB, IHC-P Human, Mouse
HY-P83696 Cytochrome P450 4A/CYP4A11 Antibody (YA3431) WB, IHC-P, IP Human, Mouse, Rat

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02647 CHMP6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CHMP6 MGD MGI:3583942
Rattus norvegicus CHMP6 RGD RGD:1565325
Canis familiaris CHMP6 VGNC VGNC:51941
Felis catus CHMP6 VGNC VGNC:98880
Bos taurus CHMP6 VGNC VGNC:27305
Macaca mulatta CHMP6 VGNC VGNC:71100
Others CHMP6 NCBI
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