2. Gene
  3. VPS36 - vacuolar protein sorting 36 homolog Gene

VPS36 - vacuolar protein sorting 36 homolog Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：液泡蛋白分选 36 同系物

种属: Homo sapiens

同用名: EAP45; C13orf9; CGI-145

基因 ID: 51028 | 基因类型: protein coding

关于 VPS36

Cytogenetic location: 13q14.3 Genomic coordinates (GRCh38): 13:52,412,606-52,450,634 (from NCBI)

This gene has 9 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in skin (RPKM 25.0), thyroid (RPKM 15.1) and 25 other tissues.

功能概要

该基因编码的蛋白质是转运 II (ESCRT-II) 所需的内体分选复合物的一个亚基。这种蛋白质复合物在内吞过程中对泛素化膜蛋白进行分类。大鼠中类似的蛋白质复合物与 RNA 聚合酶延伸因子 II 相关。[RefSeq 提供，2013 年 8 月]

This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A similar protein complex in rat is associated with RNA polymerase elongation factor II. [provided by RefSeq, Aug 2013]

VPS36 基因产物(3)

mRNA Protein Name
NM_001282168.2 NP_001269097.1 vacuolar protein-sorting-associated protein 36 isoform 2
NM_001282169.2 NP_001269098.1 vacuolar protein-sorting-associated protein 36 isoform 3
NM_016075.4 NP_057159.2 vacuolar protein-sorting-associated protein 36 isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
14505570 GOA
enables ubiquitin binding IMP
IMP: 通过突变表型推断
16973552 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of ESCRT II complex IDA
IDA: 通过直接分析推断
16973552 GOA
part of ESCRT II complex IPI
IPI: 通过物理相互作用推断
18539118 GOA
located in cytosol IDA
IDA: 通过直接分析推断
17010938 GOA
located in endosome IDA
IDA: 通过直接分析推断
20682791 GOA
located in late endosome membrane IDA
IDA: 通过直接分析推断
17010938 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

VPS36 蛋白结构

Vps36_ESCRT-II

Vps36_ESCRT-II: Vacuolar protein sorting protein 36 Vps36 (6 - 88)

EAP30

EAP30: EAP30/Vps36 family (154 - 369)

  • 0
  • 100
  • 200
  • 300
  • 386 a.a.
蛋白主名 其他名称

vacuolar protein-sorting-associated protein 36

ELL-associated protein of 45 kDa

VPS36 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra VPS36 Q86VN1 VPS25 Homo sapiens Q9BRG1
Anti Tag CoIP
35271311
Intra VPS36 Q86VN1 VPS25 Homo sapiens Q9BRG1
Anti Tag CoIP
28514442
Intra VPS36 Q86VN1 VPS25 Homo sapiens Q9BRG1
Validated Y2H
32296183
Intra VPS36 Q86VN1 SNF8 Homo sapiens Q96H20
Validated Y2H
32296183
Intra VPS36 Q86VN1 SNF8 Homo sapiens Q96H20
Anti Tag CoIP
28514442
Intra VPS36 Q86VN1 SNF8 Homo sapiens Q96H20
Y2H Array
32296183
Intra VPS36 Q86VN1 SNF8 Homo sapiens Q96H20
Anti Tag CoIP
35271311
Intra VPS36 Q86VN1 SNF8 Homo sapiens Q96H20
Y2H Prey Pooling
32296183
Intra VPS36 Q86VN1 SNF8 Homo sapiens Q96H20
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Conventional Lipoma

Classic Type Lipoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15687 VPS36 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris VPS36 VGNC VGNC:48286
Felis catus VPS36 VGNC VGNC:66966
Mus musculus VPS36 MGD MGI:1917410
Bos taurus VPS36 VGNC VGNC:36819
Rattus norvegicus VPS36 RGD RGD:1309754
Macaca mulatta VPS36 VGNC VGNC:79241
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