2. Gene
  3. ASPG - asparaginase Gene

ASPG - asparaginase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：天门冬酰胺酶

种属: Homo sapiens

同用名: GPA/WT; LYSOLP; C14orf76; hASNase1

基因 ID: 374569 | 基因类型: protein coding

关于 ASPG

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:104,085,700-104,115,582 (from NCBI)

This gene has 9 transcripts (splice variants) and 207 orthologues. Biased expression in liver (RPKM 7.5), kidney (RPKM 3.8) and 8 other tissues.

功能概要

预测可启用酰基转移酶活性，转移氨基酰基以外的基团；天冬酰胺酶活性；和溶血磷脂酶活性。预计参与天冬酰胺代谢过程和磷脂代谢过程。预测位于胞质溶胶中。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable Acyltransferase activity, transferring groups Other than amino-acyl groups; asparaginase activity; and lysophospholipase activity. Predicted to be involved in asparagine metabolic process and phospholipid metabolic process. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

ASPG 基因产物(2)

mRNA Protein Name
NM_001080464.3 NP_001073933.2 60 kDa lysophospholipase isoform 1
NM_001411060.1 NP_001397989.1 60 kDa lysophospholipase isoform 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ASPG 蛋白结构

Asparaginase

Asparaginase: Asparaginase, N-terminal (11 - 344)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (407 - 495)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 573 a.a.
蛋白主名 其他名称

60 kDa lysophospholipase

PAF acetylhydrolase

ASPG 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ASPG Q86U10 CIMIP1 Homo sapiens Q9H1P6
Validated Y2H
32296183
种属内
ASPG Q86U10 MYOZ3 Homo sapiens Q8TDC0
Validated Y2H
32296183
种属内
ASPG Q86U10 VPS25 Homo sapiens Q9BRG1
Validated Y2H
32296183
种属内
ASPG Q86U10 SHC3 Homo sapiens Q92529
Validated Y2H
32296183
种属内
ASPG Q86U10 TEKT3 Homo sapiens Q9BXF9
Validated Y2H
32296183
种属内
ASPG Q86U10 DMRT3 Homo sapiens Q9NQL9
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Esophagus Lymphoma

Lymphoma Of Esophagus

Lymphoma Of Oesophagus

Oesophagus Lymphoma

Esophageal Lymphoma
Testicular Leukemia
Adult Acute Lymphocytic Leukemia

Adult Acute Lymphoid Leukemia

Adult All
Childhood Leukemia
Central Nervous System Leukemia

Leukemia Of The Cns
Mastoiditis

Mastoiditis Nec
Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01101 ASPG Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus ASPG VGNC VGNC:26218
Macaca mulatta ASPG VGNC VGNC:70101
Canis familiaris ASPG VGNC VGNC:50441
Felis catus ASPG VGNC VGNC:59975
Rattus norvegicus ASPG RGD RGD:708388
Mus musculus ASPG MGD MGI:2144822
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