HMG20B - high mobility group 20B Gene

中文名称：高机动性组 20B

种属: Homo sapiens

同用名: SOXL; HMGX2; BRAF25; BRAF35; HMGXB2; PP7706; pp8857; SMARCE1r

基因 ID: 10362 | 基因类型: protein coding

关于 HMG20B

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,572,944-3,579,083 (from NCBI)

This gene has 16 transcripts (splice variants), 190 orthologues and 20 paralogues. Ubiquitous expression in prostate (RPKM 40.0), kidney (RPKM 22.5) and 25 other tissues.

功能概要

预测启用 DNA 结合活性。预计参与基因表达的调控。预计在蛋白质苏木化的负调节上游或负调节内起作用；神经元分化的正向调节；和骨骼肌细胞分化。位于核体。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable DNA binding activity. Predicted to be involved in regulation of gene expression. Predicted to act upstream of or within negative regulation of protein sumoylation; positive regulation of neuron differentiation; and skeletal muscle cell differentiation. Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

HMG20B 基因产物(1)

mRNA	Protein	Name
NM_006339.3	NP_006330.2	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	21399666	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HMG20B 蛋白结构

HMG_box

0
100
200
317 a.a.

蛋白主名

其他名称

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

BRCA2-associated factor 35

HMG20B 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	HMG20B	Q9P0W2	CCDC136	Homo sapiens	Q96JN2-2	Y2H Prey Pooling	25416956
种属内	HMG20B	Q9P0W2	CCDC136	Homo sapiens	Q96JN2-2	Validated Y2H	25416956
种属内	HMG20B	Q9P0W2	CCDC102B	Homo sapiens	Q68D86	Validated Y2H	25416956
种属内	HMG20B	Q9P0W2	CCDC102B	Homo sapiens	Q68D86	Y2H Array	25416956
种属内	HMG20B	Q9P0W2	KRT38	Homo sapiens	O76015	Y2H Array	29892012
种属内	HMG20B	Q9P0W2	KRT38	Homo sapiens	O76015	Y2H Prey Pooling	25416956
种属内	HMG20B	Q9P0W2	KRT38	Homo sapiens	O76015	Validated Y2H	25416956
种属内	HMG20B	Q9P0W2	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Array	32296183
种属内	HMG20B	Q9P0W2	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Prey Pooling	32296183
种属内	HMG20B	Q9P0W2	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	25416956
种属内	HMG20B	Q9P0W2	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
种属内	HMG20B	Q9P0W2	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
种属内	HMG20B	Q9P0W2	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
种属内	HMG20B	Q9P0W2	SNAPC5	Homo sapiens	O75971-2	Y2H Prey Pooling	32296183
种属内	HMG20B	Q9P0W2	SNAPC5	Homo sapiens	O75971-2	Y2H Array	32296183
种属内	HMG20B	Q9P0W2	KLK6	Homo sapiens	Q92876	Validated Y2H	32814053
种属内	HMG20B	Q9P0W2	KLK6	Homo sapiens	Q92876	Y2H Pooling	32814053
种属内	HMG20B	Q9P0W2	KLK6	Homo sapiens	Q92876	Y2H Array	32814053
种属内	HMG20B	Q9P0W2	PIAS2	Homo sapiens	O75928-2	Y2H Array	32296183
种属内	HMG20B	Q9P0W2	PIAS2	Homo sapiens	O75928-2	Y2H Prey Pooling	32296183
种属内	HMG20B	Q9P0W2	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
种属内	HMG20B	Q9P0W2	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
种属内	HMG20B	Q9P0W2	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
种属内	HMG20B	Q9P0W2	SYCE1	Homo sapiens	Q8N0S2	Y2H Prey Pooling	25416956
种属内	HMG20B	Q9P0W2	SYCE1	Homo sapiens	Q8N0S2	Validated Y2H	25416956
种属内	HMG20B	Q9P0W2	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	25416956
种属内	HMG20B	Q9P0W2	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	32296183
种属内	HMG20B	Q9P0W2	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	32296183
种属内	HMG20B	Q9P0W2	HMG20A	Homo sapiens	Q9NP66	Y2H Prey Pooling	32296183
种属内	HMG20B	Q9P0W2	HMG20A	Homo sapiens	Q9NP66	Y2H Array	32296183
种属内	HMG20B	Q9P0W2	HMG20A	Homo sapiens	Q9NP66	Anti Tag CoIP	33961781
种属内	HMG20B	Q9P0W2	ERP29	Homo sapiens	P30040	Y2H Prey Pooling	32296183
种属内	HMG20B	Q9P0W2	ERP29	Homo sapiens	P30040	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Nephrolithiasis/Osteoporosis, Hypophosphatemic, 2

Hypophosphatemic Nephrolithiasis/Osteoporosis 2	NPHLOP2
Nephrolithiasis-Osteoporosis, Hypophosphatemic, 2	Nephrolithiasis/Osteoporosis, Hypophosphatemic, Type 2

Frontonasal Dysplasia 2

FND2	Frontonasal Dysplasia With Alopecia And Genital Anomaly
Frontonasal Dysplasia-Alopecia-Genital Anomalies Syndrome	Alx4-Related Fndag
Craniofrontonasal Dysplasia With Alopecia And Hypogonadism	Frontonasal Dysplasia Type 2
Frontonasal Dysplasia With Alopecia And Genital Abnomality	Doid:0081046
Dysplasia, Frontonasal, Type 2

Barber-Say Syndrome

Hypertrichosis, Atrophic Skin, Ectropion, And Macrostomia	Barber Say Syndrome
BBRSAY	Bss
Hypertrichosis Atrophic Skin Ectropion Macrostomia	Hypertrichosis-Atrophic Skin-Ectropion-Macrostomia Syndrome

Coffin-Siris Syndrome 9

Mrd27	CSS9
Mental Retardation, Autosomal Dominant 27	Autosomal Dominant Mental Retardation 27
Autosomal Dominant Non-Syndromic Intellectual Disability 27	Coffin-Siris Syndrome, Type 9

Hypophosphatemic Nephrolithiasis/Osteoporosis

Nephrolithiasis/Osteoporosis, Hypophosphatemic

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06229	HMG20B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	HMG20B	VGNC	VGNC:41708
Felis catus	HMG20B	VGNC	VGNC:67593
Mus musculus	HMG20B	MGD	MGI:1341190
Rattus norvegicus	HMG20B	RGD	RGD:1309235

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