2. Gene
  3. CINP - cyclin dependent kinase 2 interacting protein Gene

CINP - cyclin dependent kinase 2 interacting protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：细胞周期蛋白依赖性激酶 2 相互作用蛋白

种属: Homo sapiens

基因 ID: 51550 | 基因类型: protein coding

关于 CINP

Cytogenetic location: 14q32.31 Genomic coordinates (GRCh38): 14:102,348,282-102,362,890 (from NCBI)

This gene has 9 transcripts (splice variants) and 211 orthologues. Ubiquitous expression in testis (RPKM 6.8), brain (RPKM 6.4) and 25 other tissues.

功能概要

据报道，由该基因编码的蛋白质是 DNA 复制复合体的一个组成部分，也是一种基因组维持蛋白。它可能与对复制启动很重要的蛋白质相互作用，并且已显示在细胞周期的 G1 期结合染色质，并在复制启动时与染色质分离。它还可以作为 DNA 损伤反应的一部分来调节检查点信号。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 2 月]

The protein encoded by this gene is reported to be a component of the DNA replication complex as well as a genome-maintenance protein. It may interact with proteins important for replication initiation and has been shown to bind chromatin at the G1 phase of the cell cycle and dissociate from chromatin with replication initiation. It may also serve to regulate checkpoint signaling as part of the DNA damage response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

CINP 基因产物(2)

mRNA Protein Name
NM_001320046.2 NP_001306975.1 cyclin-dependent kinase 2-interacting protein isoform 2
NM_032630.3 NP_116019.1 cyclin-dependent kinase 2-interacting protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables preribosome binding IDA
IDA: 通过直接分析推断
35354024 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ribosomal large subunit biogenesis IDA
IDA: 通过直接分析推断
35354024 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cyclin-dependent kinase 2-interacting protein

CDK2-interacting protein

CINP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CINP Q9BW66 GAS8 Homo sapiens O95995
Y2H Array
32296183
Intra CINP Q9BW66 GAS8 Homo sapiens O95995
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra CINP Q9BW66 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 MMADHC Homo sapiens Q9H3L0
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 MMADHC Homo sapiens Q9H3L0
Validated Y2H
32296183
Intra CINP Q9BW66 MMADHC Homo sapiens Q9H3L0
Y2H Array
32296183
Intra CINP Q9BW66 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
Intra CINP Q9BW66 CFAP161 Homo sapiens Q6P656
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 CFAP161 Homo sapiens Q6P656
Y2H Array
32296183
Intra CINP Q9BW66 MINAR1 Homo sapiens Q9UPX6
Validated Y2H
32296183
Intra CINP Q9BW66 MINAR1 Homo sapiens Q9UPX6
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 MINAR1 Homo sapiens Q9UPX6
Y2H Array
32296183
Intra CINP Q9BW66 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra CINP Q9BW66 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 INADL Homo sapiens A5PKX9
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 INADL Homo sapiens A5PKX9
Y2H Array
32296183
Intra CINP Q9BW66 CCDC112 Homo sapiens Q8NEF3-2
Y2H Array
32296183
Intra CINP Q9BW66 CCDC112 Homo sapiens Q8NEF3-2
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 ZBTB42 Homo sapiens B2RXF5
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 ZBTB42 Homo sapiens B2RXF5
Y2H Array
32296183
Intra CINP Q9BW66 NDUFB7 Homo sapiens P17568
Y2H Array
32296183
Intra CINP Q9BW66 NDUFB7 Homo sapiens P17568
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 PRRX1 Homo sapiens P54821
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 PRRX1 Homo sapiens P54821
Y2H Array
32296183
Intra CINP Q9BW66 ZNF19 Homo sapiens P17023
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 ZNF19 Homo sapiens P17023
Y2H Array
32296183
Intra CINP Q9BW66 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra CINP Q9BW66 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 TXNRD3NB Homo sapiens Q6F5E7
Y2H Array
32296183
Intra CINP Q9BW66 TXNRD3NB Homo sapiens Q6F5E7
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 BLZF1 Homo sapiens Q9H2G9
Validated Y2H
32296183
Intra CINP Q9BW66 BLZF1 Homo sapiens Q9H2G9
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 BLZF1 Homo sapiens Q9H2G9
Y2H Array
32296183
Intra CINP Q9BW66 BLZF1 Homo sapiens Q9H2G9
Validated Y2H
25416956
Intra CINP Q9BW66 KANK2 Homo sapiens Q63ZY3
Y2H Array
32296183
Intra CINP Q9BW66 KANK2 Homo sapiens Q63ZY3
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 MZT1 Homo sapiens Q08AG7
Y2H Array
32296183
Intra CINP Q9BW66 MZT1 Homo sapiens Q08AG7
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 SNRPD2 Homo sapiens P62316
Y2H Array
32296183
Intra CINP Q9BW66 SNRPD2 Homo sapiens P62316
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 REL Homo sapiens Q04864
Y2H Prey Pooling
25416956
Intra CINP Q9BW66 REL Homo sapiens Q04864
Y2H Array
25416956
Intra CINP Q9BW66 REL Homo sapiens Q04864
Validated Y2H
25416956
Intra CINP Q9BW66 PSMA1 Homo sapiens P25786
Y2H Array
32296183
Intra CINP Q9BW66 PSMA1 Homo sapiens P25786
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 ZNF620 Homo sapiens Q6ZNG0
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 ZNF620 Homo sapiens Q6ZNG0
Y2H Array
32296183
Intra CINP Q9BW66 MAGEA3 Homo sapiens P43357
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 MAGEA3 Homo sapiens P43357
Y2H Array
32296183
Intra CINP Q9BW66 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra CINP Q9BW66 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra CINP Q9BW66 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra CINP Q9BW66 BTBD2 Homo sapiens Q9BX70
Y2H Array
32296183
Intra CINP Q9BW66 BTBD2 Homo sapiens Q9BX70
Validated Y2H
32296183
Intra CINP Q9BW66 BTBD2 Homo sapiens Q9BX70
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 FAM161B Homo sapiens Q96MY7
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 FAM161B Homo sapiens Q96MY7
Y2H Array
32296183
Intra CINP Q9BW66 CLUAP1 Homo sapiens Q96AJ1
Y2H Array
32296183
Intra CINP Q9BW66 CLUAP1 Homo sapiens Q96AJ1
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 PRC1 Homo sapiens O43663
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 PRC1 Homo sapiens O43663
Y2H Array
32296183
Intra CINP Q9BW66 FNDC11 Homo sapiens Q9BVV2
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 FNDC11 Homo sapiens Q9BVV2
Y2H Array
32296183
Intra CINP Q9BW66 AMOTL2 Homo sapiens Q9Y2J4
Validated Y2H
32296183
Intra CINP Q9BW66 AMOTL2 Homo sapiens Q9Y2J4
Y2H Array
32296183
Intra CINP Q9BW66 AMOTL2 Homo sapiens Q9Y2J4
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 PAX6 Homo sapiens P26367
Y2H Array
32296183
Intra CINP Q9BW66 ATRIP Homo sapiens Q8WXE1
Anti Bait CoIP
19889979
Intra CINP Q9BW66 ATRIP Homo sapiens Q8WXE1
Validated Y2H
25416956
Intra CINP Q9BW66 ATRIP Homo sapiens Q8WXE1
Y2H Array
25416956
Intra CINP Q9BW66 ATRIP Homo sapiens Q8WXE1
Anti Tag CoIP
19889979
Intra CINP Q9BW66 ATRIP Homo sapiens Q8WXE1
Y2H Prey Pooling
25416956
Intra CINP Q9BW66 ATRIP Homo sapiens Q8WXE1
Y2H
19889979
Intra CINP Q9BW66 SERTAD1 Homo sapiens Q9UHV2
Validated Y2H
32296183
Intra CINP Q9BW66 SERTAD1 Homo sapiens Q9UHV2
Y2H Array
32296183
Intra CINP Q9BW66 SERTAD1 Homo sapiens Q9UHV2
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 AIRIM Homo sapiens Q9NX04
Y2H Array
32296183
Intra CINP Q9BW66 AIRIM Homo sapiens Q9NX04
Anti Tag CoIP
28514442
Intra CINP Q9BW66 AIRIM Homo sapiens Q9NX04
Anti Tag CoIP
33961781
Intra CINP Q9BW66 AIRIM Homo sapiens Q9NX04
Y2H Prey Pooling
25416956
Intra CINP Q9BW66 AIRIM Homo sapiens Q9NX04
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
Intra CINP Q9BW66 AIRIM Homo sapiens Q9NX04
Y2H Array
25416956
Intra CINP Q9BW66 SP2 Homo sapiens Q02086-2
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 SP2 Homo sapiens Q02086-2
Y2H Array
32296183
Intra CINP Q9BW66 COG3 Homo sapiens Q96JB2-2
Y2H Prey Pooling
32296183
Intra CINP Q9BW66 COG3 Homo sapiens Q96JB2-2
Y2H Array
32296183
Intra CINP Q9BW66 ATR Homo sapiens Q13535
Anti Bait CoIP
19889979
Intra CINP Q9BW66 ATR Homo sapiens Q13535
Anti Tag CoIP
19889979
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome

Jacobs Syndrome

Arthropathy-Camptodactyly Syndrome

Pericarditis-Arthropathy-Camptodactyly Syndrome

Xyy Syndrome

Pac Syndrome

Cacp Syndrome

CACP

Fibrosing Serositis, Familial

Camptodactyly-Arthropathy-Pericarditis Syndrome

Cap Syndrome

47, Xyy Syndrome

47,Xyy Syndrome

Double Y Syndrome

Camptodactyly-Arthropathy-Coxa-Vara-Pericarditis Syndrome

Hypertrophic Synovitis, Congenital Familial

Congenital Familial Hypertrophic Synovitis

Xyy Karyotype

Y Disomy

Yy Syndrome

Familial Fibrosing Serositis

Disomy Y

Double Y

Camptodactyly Arthropathy Coxa Vara Pericarditis Syndrome

Arthropathy Camptodactyly Syndrome

Camptodactyly Arthropathy Pericarditis Syndrome

Pericarditis Arthropathy Camptodactyly Syndrome

Jacob'S Syndrome

47,Xyy

Cdags Syndrome
Seckel Syndrome

Microcephalic Primordial Dwarfism

Bird-Headed Dwarfism

Harper'S Syndrome

Virchow-Seckel Dwarfism

Nanocephalic Dwarfism

Sckl

Seckel-Type Dwarfism
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02717 CINP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CINP VGNC VGNC:39276
Mus musculus CINP MGD MGI:1914486
Macaca mulatta CINP VGNC VGNC:71326
Rattus norvegicus CINP RGD RGD:1563395
Felis catus CINP VGNC VGNC:60905
Bos taurus CINP VGNC VGNC:27368
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