PRRX1 - paired related homeobox 1 Gene

中文名称：配对相关同源框 1

种属: Homo sapiens

同用名: PMX1; PRX1; AGOTC; PHOX1; PRX-1

关于 PRRX1

功能概要

由该基因编码的 DNA 相关蛋白是定位于细胞核的同源框蛋白配对家族的成员。该蛋白质作为转录共激活剂发挥作用，增强血清反应因子的 DNA 结合活性，血清反应因子是生长和分化因子诱导基因所需的蛋白质。该蛋白质调节肌肉肌酸激酶，表明在建立不同的中胚层肌肉类型中发挥作用。选择性剪接会产生两种丰度和表达模式不同的亚型。[RefSeq 提供，2008 年 7 月]

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns. [provided by RefSeq, Jul 2008]