CYTH3 - cytohesin 3 Gene

中文名称：细胞粘附素 3

种属: Homo sapiens

同用名: GRP1; ARNO3; PSCD3; cytohesin-3

关于 CYTH3

功能概要

该基因编码 PSCD (pleckstrin 同源性、Sec7 和卷曲螺旋结构域) 家族的成员。 PSCD 家族成员具有相同的结构组织，由 N 末端卷曲螺旋基序、中央 Sec7 结构域和 C 末端 pleckstrin 同源 (PH) 结构域组成。卷曲螺旋基序参与同源二聚化，Sec7 结构域包含鸟嘌呤核苷酸交换蛋白 (GEP) 活性，PH 结构域与磷脂相互作用并负责 PSCD 与膜的结合。该家族的成员似乎调节蛋白质分选和膜运输的调节。这种编码的蛋白质参与高尔基体结构和功能的控制，除了作用于 ARF1 外，它还可能在调节 ADP-核糖基化因子蛋白 6 (ARF) 功能方面发挥生理作用。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with Phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1. [provided by RefSeq, Jul 2008]