1. Gene
  2. BEX2 - brain expressed X-linked 2 Gene

BEX2 - brain expressed X-linked 2 Gene

中文名称:脑表达 X 连锁 2

种属: Homo sapiens

同用名: BEX1; DJ79P11.1

基因 ID: 84707 | 基因类型: protein coding

关于 BEX2

Cytogenetic location: Xq22.2 Genomic coordinates (GRCh38): X:103,309,346-103,310,990 (from NCBI)

This gene has 4 transcripts (splice variants), 149 orthologues and 3 paralogues. Broad expression in brain (RPKM 60.5), thyroid (RPKM 40.0) and 14 other tissues.

功能概要

该基因属于脑表达 X 连锁基因家族。编码的蛋白质与识别 E-box 元素并促进转录的 DNA 结合复合物中的转录因子 LIM 域仅 2 相互作用。已发现该基因是在人类神经胶质瘤中沉默的肿瘤抑制因子。在乳腺癌细胞中,该基因产物调节细胞凋亡以响应雌激素和他莫昔芬,并增强他莫昔芬的抗增殖作用。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供,2009 年 12 月]

This gene belongs to the brain expressed X-linked gene family. The encoded protein interacts with the transcription factor LIM domain only 2 in a DNA-binding complex that recognizes the E-box element and promotes transcription. This gene has been found to be a tumor suppressor that is silenced in human glioma. In breast Cancer cells, this gene product modulates Apoptosis in response to estrogen and tamoxifen, and enhances the anti-proliferative effect of tamoxifen. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

BEX2 基因产物(4)

mRNA Protein Name
NM_001168399.2 NP_001161871.1 protein BEX2 isoform 1
NM_001168400.2 NP_001161872.1 protein BEX2 isoform 2
NM_001168401.2 NP_001161873.1 protein BEX2 isoform 3
NM_032621.4 NP_116010.1 protein BEX2 isoform 3
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of apoptotic process IDA
IDA: 通过直接分析推断
19711341 GOA
involved in regulation of cell cycle IDA
IDA: 通过直接分析推断
19711341 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

BEX2 蛋白结构

BEX

BEX: Brain expressed X-linked like family (14 - 127)

  • 0
  • 100
  • 128 a.a.
蛋白主名 其他名称

protein BEX2

brain-expressed X-linked protein 2

BEX2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
BEX2 Q9BXY8 KRT40 Homo sapiens Q6A162 25416956
种属内
BEX2 Q9BXY8 KRT40 Homo sapiens Q6A162 25416956
种属内
BEX2 Q9BXY8 KRTAP10-8 Homo sapiens P60410 32296183
种属内
BEX2 Q9BXY8 KRTAP10-8 Homo sapiens P60410 25416956
种属内
BEX2 Q9BXY8 KRTAP10-8 Homo sapiens P60410 32296183
种属内
BEX2 Q9BXY8 NECAB2 Homo sapiens Q7Z6G3-2 25416956
种属内
BEX2 Q9BXY8 NECAB2 Homo sapiens Q7Z6G3-2 25416956
种属内
BEX2 Q9BXY8 KRTAP12-2 Homo sapiens P59991 32296183
种属内
BEX2 Q9BXY8 KRTAP12-2 Homo sapiens P59991 32296183
种属内
BEX2 Q9BXY8 MAGEA11 Homo sapiens P43364-2 25416956
种属内
BEX2 Q9BXY8 BORCS6 Homo sapiens Q96GS4 32296183
种属内
BEX2 Q9BXY8 BORCS6 Homo sapiens Q96GS4 32296183
种属内
BEX2 Q9BXY8 MAGEA4 Homo sapiens Q1RN33 25416956
种属内
BEX2 Q9BXY8 MAGEA4 Homo sapiens Q1RN33 25416956
种属内
BEX2 Q9BXY8 MAGEA4 Homo sapiens Q1RN33 25416956
种属内
BEX2 Q9BXY8 TRIM74 Homo sapiens Q86UV6-2 32296183
种属内
BEX2 Q9BXY8 TRIM74 Homo sapiens Q86UV6-2 32296183
种属内
BEX2 Q9BXY8 NFKBID Homo sapiens Q8NI38 32296183
种属内
BEX2 Q9BXY8 NFKBID Homo sapiens Q8NI38 32296183
种属内
BEX2 Q9BXY8 KRT34 Homo sapiens O76011 32296183
种属内
BEX2 Q9BXY8 KRT34 Homo sapiens O76011 32296183
种属内
BEX2 Q9BXY8 KRT38 Homo sapiens O76015 25416956
种属内
BEX2 Q9BXY8 KRT38 Homo sapiens O76015 25416956
种属内
BEX2 Q9BXY8 KRT38 Homo sapiens O76015 25416956
种属内
BEX2 Q9BXY8 KRTAP11-1 Homo sapiens Q8IUC1 32296183
种属内
BEX2 Q9BXY8 KRTAP11-1 Homo sapiens Q8IUC1 32296183
种属内
BEX2 Q9BXY8 KLHL20 Homo sapiens Q9BS75 32296183
种属内
BEX2 Q9BXY8 KLHL20 Homo sapiens Q9BS75 32296183
种属内
BEX2 Q9BXY8 CCDC57 Homo sapiens Q2TAC2-2 32296183
种属内
BEX2 Q9BXY8 CCDC57 Homo sapiens Q2TAC2-2 32296183
种属内
BEX2 Q9BXY8 GPRASP3 Homo sapiens Q6PI77 32296183
种属内
BEX2 Q9BXY8 GPRASP3 Homo sapiens Q6PI77 32296183
种属内
BEX2 Q9BXY8 MTUS2 Homo sapiens Q5JR59-3 32296183
种属内
BEX2 Q9BXY8 MTUS2 Homo sapiens Q5JR59-3 32296183
种属内
BEX2 Q9BXY8 TRIM69 Homo sapiens Q86WT6-2 32296183
种属内
BEX2 Q9BXY8 TRIM69 Homo sapiens Q86WT6-2 32296183
种属内
BEX2 Q9BXY8 MSS51 Homo sapiens Q4VC12 32296183
种属内
BEX2 Q9BXY8 MSS51 Homo sapiens Q4VC12 32296183
种属内
BEX2 Q9BXY8 AKAP9 Homo sapiens Q6PJH3 32296183
种属内
BEX2 Q9BXY8 AKAP9 Homo sapiens Q6PJH3 32296183
种属内
BEX2 Q9BXY8 CDR2 Homo sapiens Q01850 32296183
种属内
BEX2 Q9BXY8 CDR2 Homo sapiens Q01850 32296183
种属内
BEX2 Q9BXY8 CTAG1A Homo sapiens P78358 32296183
种属内
BEX2 Q9BXY8 CTAG1A Homo sapiens P78358 32296183
种属内
BEX2 Q9BXY8 LCN2 Homo sapiens P80188 32296183
种属内
BEX2 Q9BXY8 LCN2 Homo sapiens P80188 32296183
种属内
BEX2 Q9BXY8 KRT39 Homo sapiens Q6A163 32296183
种属内
BEX2 Q9BXY8 KRT39 Homo sapiens Q6A163 32296183
种属内
BEX2 Q9BXY8 KRTAP6-2 Homo sapiens Q3LI66 32296183
种属内
BEX2 Q9BXY8 KRTAP6-2 Homo sapiens Q3LI66 32296183
种属内
BEX2 Q9BXY8 VPS28 Homo sapiens Q9UK41-2 32296183
种属内
BEX2 Q9BXY8 VPS28 Homo sapiens Q9UK41-2 32296183
种属内
BEX2 Q9BXY8 VPS28 Homo sapiens Q9UK41-2 32296183
种属内
BEX2 Q9BXY8 SPRY3 Homo sapiens O43610 32296183
种属内
BEX2 Q9BXY8 SPRY3 Homo sapiens O43610 32296183
种属内
BEX2 Q9BXY8 ZNF19 Homo sapiens P17023 32296183
种属内
BEX2 Q9BXY8 ZNF19 Homo sapiens P17023 32296183
种属内
BEX2 Q9BXY8 KRTAP2-4 Homo sapiens Q9BYR9 32296183
种属内
BEX2 Q9BXY8 KRTAP2-4 Homo sapiens Q9BYR9 32296183
种属内
BEX2 Q9BXY8 KRTAP2-4 Homo sapiens Q9BYR9 32296183
种属内
BEX2 Q9BXY8 FST Homo sapiens P19883 32296183
种属内
BEX2 Q9BXY8 FST Homo sapiens P19883 32296183
种属内
BEX2 Q9BXY8 KRTAP21-2 Homo sapiens Q3LI59 32296183
种属内
BEX2 Q9BXY8 KRTAP21-2 Homo sapiens Q3LI59 32296183
种属内
BEX2 Q9BXY8 KRTAP6-3 Homo sapiens Q3LI67 32296183
种属内
BEX2 Q9BXY8 KRTAP6-3 Homo sapiens Q3LI67 32296183
种属内
BEX2 Q9BXY8 MKRN3 Homo sapiens Q13064 32296183
种属内
BEX2 Q9BXY8 MKRN3 Homo sapiens Q13064 25416956
种属内
BEX2 Q9BXY8 MKRN3 Homo sapiens Q13064 32296183
种属内
BEX2 Q9BXY8 BLZF1 Homo sapiens Q9H2G9 32296183
种属内
BEX2 Q9BXY8 BLZF1 Homo sapiens Q9H2G9 25416956
种属内
BEX2 Q9BXY8 BLZF1 Homo sapiens Q9H2G9 32296183
种属内
BEX2 Q9BXY8 BLZF1 Homo sapiens Q9H2G9 32296183
种属内
BEX2 Q9BXY8 BLZF1 Homo sapiens Q9H2G9 25416956
种属内
BEX2 Q9BXY8 MIPOL1 Homo sapiens Q8TD10 25416956
种属内
BEX2 Q9BXY8 TACC3 Homo sapiens Q9Y6A5 32296183
种属内
BEX2 Q9BXY8 TACC3 Homo sapiens Q9Y6A5 32296183
种属内
BEX2 Q9BXY8 TACC3 Homo sapiens Q9Y6A5 32296183
种属内
BEX2 Q9BXY8 KRT75 Homo sapiens O95678 32296183
种属内
BEX2 Q9BXY8 KRT75 Homo sapiens O95678 32296183
种属内
BEX2 Q9BXY8 PNMA1 Homo sapiens Q8ND90 25416956
种属内
BEX2 Q9BXY8 KRT27 Homo sapiens Q7Z3Y8 32296183
种属内
BEX2 Q9BXY8 KRT27 Homo sapiens Q7Z3Y8 32296183
种属内
BEX2 Q9BXY8 CCDC88B Homo sapiens A6NC98 32296183
种属内
BEX2 Q9BXY8 CCDC88B Homo sapiens A6NC98 32296183
种属内
BEX2 Q9BXY8 TRAF2 Homo sapiens Q12933 25416956
种属内
BEX2 Q9BXY8 TRAF2 Homo sapiens Q12933 32296183
种属内
BEX2 Q9BXY8 TRAF2 Homo sapiens Q12933 25416956
种属内
BEX2 Q9BXY8 TRAF2 Homo sapiens Q12933 32296183
种属内
BEX2 Q9BXY8 TRAF1 Homo sapiens Q13077 25416956
种属内
BEX2 Q9BXY8 COG4 Homo sapiens Q9H9E3 32296183
种属内
BEX2 Q9BXY8 COG4 Homo sapiens Q9H9E3 32296183
种属内
BEX2 Q9BXY8 COG4 Homo sapiens Q9H9E3 32296183
种属内
BEX2 Q9BXY8 KNSTRN Homo sapiens Q9Y448 32296183
种属内
BEX2 Q9BXY8 KNSTRN Homo sapiens Q9Y448 32296183
种属内
BEX2 Q9BXY8 KNSTRN Homo sapiens Q9Y448 32296183
种属内
BEX2 Q9BXY8 CYSRT1 Homo sapiens A8MQ03 32296183
种属内
BEX2 Q9BXY8 CYSRT1 Homo sapiens A8MQ03 32296183
种属内
BEX2 Q9BXY8 KRTAP3-3 Homo sapiens Q9BYR6 32296183
种属内
BEX2 Q9BXY8 KRTAP3-3 Homo sapiens Q9BYR6 32296183
种属内
BEX2 Q9BXY8 KRTAP3-3 Homo sapiens Q9BYR6 32296183
种属内
BEX2 Q9BXY8 PRDM14 Homo sapiens Q9GZV8 25416956
种属内
BEX2 Q9BXY8 KRTAP5-9 Homo sapiens P26371 25416956
种属内
BEX2 Q9BXY8 KRTAP5-9 Homo sapiens P26371 25416956
种属内
BEX2 Q9BXY8 KRTAP5-9 Homo sapiens P26371 25416956
种属内
BEX2 Q9BXY8 SPRED1 Homo sapiens Q7Z699 32296183
种属内
BEX2 Q9BXY8 SPRED1 Homo sapiens Q7Z699 32296183
种属内
BEX2 Q9BXY8 TRIM42 Homo sapiens Q8IWZ5 25416956
种属内
BEX2 Q9BXY8 TRIM42 Homo sapiens Q8IWZ5 25416956
种属内
BEX2 Q9BXY8 OIP5 Homo sapiens O43482 32296183
种属内
BEX2 Q9BXY8 OIP5 Homo sapiens O43482 32296183
种属内
BEX2 Q9BXY8 MAGEA2 Homo sapiens P43356 32296183
种属内
BEX2 Q9BXY8 MAGEA2 Homo sapiens P43356 32296183
种属内
BEX2 Q9BXY8 FSD2 Homo sapiens A1L4K1 25416956
种属内
BEX2 Q9BXY8 FSD2 Homo sapiens A1L4K1 25416956
种属内
BEX2 Q9BXY8 FSD2 Homo sapiens A1L4K1 25416956
种属内
BEX2 Q9BXY8 SYCE1 Homo sapiens Q8N0S2 32296183
种属内
BEX2 Q9BXY8 SYCE1 Homo sapiens Q8N0S2 32296183
种属内
BEX2 Q9BXY8 KRT6A Homo sapiens P02538 32296183
种属内
BEX2 Q9BXY8 KRT6A Homo sapiens P02538 32296183
种属内
BEX2 Q9BXY8 HSF2BP Homo sapiens O75031 32296183
种属内
BEX2 Q9BXY8 HSF2BP Homo sapiens O75031 32296183
种属内
BEX2 Q9BXY8 TRIM27 Homo sapiens P14373 25416956
种属内
BEX2 Q9BXY8 MRPL38 Homo sapiens Q96DV4 32296183
种属内
BEX2 Q9BXY8 MRPL38 Homo sapiens Q96DV4 32296183
种属内
BEX2 Q9BXY8 MDFI Homo sapiens Q99750 32296183
种属内
BEX2 Q9BXY8 MDFI Homo sapiens Q99750 32296183
种属内
BEX2 Q9BXY8 PLA2G10 Homo sapiens O15496 32296183
种属内
BEX2 Q9BXY8 PLA2G10 Homo sapiens O15496 32296183
种属内
BEX2 Q9BXY8 HSPB2 Homo sapiens Q16082 32296183
种属内
BEX2 Q9BXY8 HSPB2 Homo sapiens Q16082 32296183
种属内
BEX2 Q9BXY8 KRT15 Homo sapiens P19012 25416956
种属内
BEX2 Q9BXY8 CEP70 Homo sapiens Q8NHQ1 25416956
种属内
BEX2 Q9BXY8 CEP70 Homo sapiens Q8NHQ1 25416956
种属内
BEX2 Q9BXY8 CEP70 Homo sapiens Q8NHQ1 32296183
种属内
BEX2 Q9BXY8 CEP70 Homo sapiens Q8NHQ1 25416956
种属内
BEX2 Q9BXY8 CEP70 Homo sapiens Q8NHQ1 32296183
种属内
BEX2 Q9BXY8 USHBP1 Homo sapiens Q8N6Y0 32296183
种属内
BEX2 Q9BXY8 USHBP1 Homo sapiens Q8N6Y0 32296183
种属内
BEX2 Q9BXY8 LDOC1 Homo sapiens O95751 32296183
种属内
BEX2 Q9BXY8 LDOC1 Homo sapiens O95751 32296183
种属内
BEX2 Q9BXY8 LZTS2 Homo sapiens Q9BRK4 25416956
种属内
BEX2 Q9BXY8 LZTS2 Homo sapiens Q9BRK4 25416956
种属内
BEX2 Q9BXY8 LZTS2 Homo sapiens Q9BRK4 25416956
种属内
BEX2 Q9BXY8 EXOC8 Homo sapiens Q8IYI6 32296183
种属内
BEX2 Q9BXY8 EXOC8 Homo sapiens Q8IYI6 32296183
种属内
BEX2 Q9BXY8 TRIP6 Homo sapiens Q15654 32296183
种属内
BEX2 Q9BXY8 TRIP6 Homo sapiens Q15654 32296183
种属内
BEX2 Q9BXY8 KRT19 Homo sapiens P08727 32296183
种属内
BEX2 Q9BXY8 KRT19 Homo sapiens P08727 32296183
种属内
BEX2 Q9BXY8 SERTAD3 Homo sapiens Q9UJW9 32296183
种属内
BEX2 Q9BXY8 SERTAD3 Homo sapiens Q9UJW9 32296183
种属内
BEX2 Q9BXY8 SERTAD3 Homo sapiens Q9UJW9 32296183
种属内
BEX2 Q9BXY8 CCDC197 Homo sapiens Q8NCU1 32296183
种属内
BEX2 Q9BXY8 CCDC197 Homo sapiens Q8NCU1 32296183
种属内
BEX2 Q9BXY8 ROPN1L Homo sapiens Q96C74 32296183
种属内
BEX2 Q9BXY8 ROPN1L Homo sapiens Q96C74 32296183
种属内
BEX2 Q9BXY8 KRT31 Homo sapiens Q15323 25416956
种属内
BEX2 Q9BXY8 KRT31 Homo sapiens Q15323 32296183
种属内
BEX2 Q9BXY8 KRT31 Homo sapiens Q15323 32296183
种属内
BEX2 Q9BXY8 PLEKHG4 Homo sapiens Q58EX7 32296183
种属内
BEX2 Q9BXY8 PLEKHG4 Homo sapiens Q58EX7 32296183
种属内
BEX2 Q9BXY8 MORN3 Homo sapiens Q6PF18 32296183
种属内
BEX2 Q9BXY8 MORN3 Homo sapiens Q6PF18 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Oligodendroglioma

Oligodendroglial Neoplasm

Oligodendroglial Tumor

Oligodendroglial Tumors

Well Differentiated Oligodendroglioma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus BEX2 RGD RGD:1564643