TACC3 - transforming acidic coiled-coil containing protein 3 Gene

中文名称：含转化酸性卷曲螺旋 3

种属: Homo sapiens

同用名: ERIC1; Tacc4; ERIC-1; maskin

基因 ID: 10460 | 基因类型: protein coding

关于 TACC3

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:1,721,521-1,745,171 (from NCBI)

This gene has 17 transcripts (splice variants), 199 orthologues, 2 paralogues and is associated with 2 phenotypes. Broad expression in testis (RPKM 25.6), bone marrow (RPKM 24.9) and 16 other tissues.

功能概要

该基因编码转化酸性大肠杆菌蛋白家族的成员。编码的蛋白质是一种运动纺锤体蛋白，可能在有丝分裂纺锤体的稳定中发挥作用。这种蛋白质也可能在某些癌细胞的生长和分化中发挥作用。[RefSeq 提供，2011 年 11 月]

This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain Cancer cells. [provided by RefSeq, Nov 2011]

TACC3 基因产物(2)

mRNA	Protein	Name
NM_001410699.1	NP_001397628.1	transforming acidic coiled-coil-containing protein 3 isoform 2
NM_006342.3	NP_006333.1	transforming acidic coiled-coil-containing protein 3 isoform 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	20360068	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in metaphase/anaphase transition of mitotic cell cycle	IMP IMP: 通过突变表型推断	23532825	GOA
involved in microtubule cytoskeleton organization involved in mitosis	IMP IMP: 通过突变表型推断	23532825	GOA
involved in regulation of mitotic spindle organization	IMP IMP: 通过突变表型推断	21297582	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TACC3 蛋白结构

TACC

0
200
400
600
838 a.a.

蛋白主名

其他名称

transforming acidic coiled-coil-containing protein 3

TACC3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	TACC3	Q9Y6A5	CIB3	Homo sapiens	Q96Q77	Y2H Array	25416956
Intra	TACC3	Q9Y6A5	CIB3	Homo sapiens	Q96Q77	Y2H Array	32296183
Intra	TACC3	Q9Y6A5	CIB3	Homo sapiens	Q96Q77	Y2H Prey Pooling	32296183
Intra	TACC3	Q9Y6A5	CLTA	Homo sapiens	P09496	Anti Bait CoIP	21297582
Intra	TACC3	Q9Y6A5	ASPSCR1	Homo sapiens	Q9BZE9	Validated Y2H	25416956
Intra	TACC3	Q9Y6A5	ASPSCR1	Homo sapiens	Q9BZE9	Y2H Array	25416956
Intra	TACC3	Q9Y6A5	IQCD	Homo sapiens	Q96DY2-2	Y2H Array	32296183
Intra	TACC3	Q9Y6A5	IQCD	Homo sapiens	Q96DY2-2	Y2H Prey Pooling	32296183
Intra	TACC3	Q9Y6A5	VPS37C	Homo sapiens	A5D8V6	Y2H Array	25416956
Intra	TACC3	Q9Y6A5	VPS37C	Homo sapiens	A5D8V6	Validated Y2H	25416956
Intra	TACC3	Q9Y6A5	EGFR	Homo sapiens	P00533	Ub Reconstruction	27956147
Intra	TACC3	Q9Y6A5	EGFR	Homo sapiens	P00533	Anti Tag CoIP	27956147
Intra	TACC3	Q9Y6A5	CKAP5	Homo sapiens	Q14008	Anti Tag CoIP	33961781
Intra	TACC3	Q9Y6A5	CKAP5	Homo sapiens	Q14008	IF	21297582
Intra	TACC3	Q9Y6A5	CKAP5	Homo sapiens	Q14008	Anti Tag CoIP	26496610
Intra	TACC3	Q9Y6A5	CKAP5	Homo sapiens	Q14008	Biochemical	21297582
Intra	TACC3	Q9Y6A5	SNX20	Homo sapiens	Q7Z614	Y2H Prey Pooling	25416956
Intra	TACC3	Q9Y6A5	SNX20	Homo sapiens	Q7Z614	Validated Y2H	25416956
Intra	TACC3	Q9Y6A5	CEP55	Homo sapiens	Q53EZ4	Y2H	27107012
Intra	TACC3	Q9Y6A5	CEP55	Homo sapiens	Q53EZ4	Anti Tag CoIP	33961781
Intra	TACC3	Q9Y6A5	CEP55	Homo sapiens	Q53EZ4	SLC	27107012
Intra	TACC3	Q9Y6A5	TBC1D22B	Homo sapiens	Q9NU19	Y2H Array	29892012
Intra	TACC3	Q9Y6A5	TBC1D22B	Homo sapiens	Q9NU19	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Gliosarcoma

Glioblastoma With Sarcomatous Component

Sarcomatous Glioblastoma

Giant Cell Glioblastoma

Monstrocellular Sarcoma

Developmental And Epileptic Encephalopathy 23

DEE23	Epileptic Encephalopathy, Early Infantile, 23
Eiee23	Early-Onset Epileptic Encephalopathy-Cortical Blindness-Intellectual Disability-Facial Dysmorphism Syndrome
Epilepsy-Cortical Blindness-Intellectual Disability-Facial Dysmorphism Syndrome	Developmental And Epileptic Encephalopathy, 23
Early Infantile Epileptic Encephalopathy 23

Thymus Lymphoma

Thymic Lymphoma

Bladder Cancer

Urinary Bladder Cancer	Bladder Carcinoma
Urinary Bladder Carcinoma	Bladder Neoplasm
Bladder Tumor	Cancer, Bladder
Malignant Neoplasm Of Urinary Bladder	Carcinoma Of Bladder
Bladder Cancer, Somatic	Tumor Of The Bladder
Carcinoma Of Urinary Bladder	Bladder Carcinoma Urinary
Cancer Of The Urinary Bladder	Cancer, Urinary Bladder
Malignant Bladder Neoplasm	Malignant Bladder Tumor
Neoplasm Of The Bladder	Neoplasm Of The Urinary Bladder
Tumor Of The Urinary Bladder	Urinary Bladder Neoplasm
BLC	Urothelial Carcinoma Of The Bladder
Bladder Tumors	Urinary Bladder Neoplasms
Bladder Cancer Nos	Vesical Cancer Nos
Malignant Neoplasm Of Bladder, Part Unspecified	Malignant Tumour Of Urinary Bladder
Primary Malignant Neoplasm Of Bladder

Wolf-Hirschhorn Syndrome

Pitt-Rogers-Danks Syndrome	WHS
Chromosome 4p16.3 Deletion Syndrome	Wittwer Syndrome
4p- Syndrome	Pitt Syndrome
4p Deletion Syndrome	Distal Deletion 4p
Distal Monosomy 4p	Telomeric Deletion 4p
Prds	4p Syndrome
Chromosome 4p Syndrome	Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation
Wolf Syndrome	Chromosome 4p Deletion Syndrome
Chromosome 4p Monosomy	Del Syndrome
Monosomy 4p	Partial Monosomy 4p
Chromosome 4 Short Arm Deletion

Fibrolamellar Carcinoma

Fibrolamellar Hepatocellular Carcinoma	Fhcc
Fibrolamellar Hepatocarcinoma	Hepatocellular Carcinoma, Fibrolamellar
Oncocytic Hepatocellular Tumor	Eosinophilic Glassy Cell Hepatoma
Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis	Fl-Hcc
Fibrolamellar Oncocytic Hepatoma	Hepatocellular Carcinoma With Increased Stromal Fibrosis
Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-10996A	KHS101 hydrochloride		99.84%	否
HY-135960	BO-264		99.63%	否
HY-120087	KG-548	Inhibitor	99.92%	否
HY-145895	SNIPER(TACC3)-11	Inhibitor	99.58%	否
HY-111876	SNIPER(TACC3)-1		99.51%	否
HY-111877	SNIPER(TACC3)-2		99.81%	否
HY-W012248	KG-655	Modulator	99.87%	否
HY-10996	KHS101		/	否
HY-111876A	SNIPER(TACC3)-1 hydrochloride		/	否
HY-111877A	SNIPER(TACC3)-2 hydrochloride		/	否
HY-151985	TACC3 inhibitor 1	Inducer	/	否
HY-RS14141	TACC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	TACC3	VGNC	VGNC:53244
Bos taurus	TACC3	VGNC	VGNC:53778
Macaca mulatta	TACC3	VGNC	VGNC:78082
Rattus norvegicus	TACC3	RGD	RGD:1302948
Mus musculus	TACC3	MGD	MGI:1341163
Felis catus	TACC3	VGNC	VGNC:82312

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TACC3 - transforming acidic coiled-coil containing protein 3 Gene

关于 TACC3

功能概要

TACC3 基因产物(2)

TACC3 蛋白结构

TACC3 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

TACC3 - transforming acidic coiled-coil containing protein 3 Gene

关于 TACC3

功能概要

TACC3 基因产物(2)

TACC3 蛋白结构

TACC3 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z