1. Gene
  2. CLTA - clathrin light chain A Gene

CLTA - clathrin light chain A Gene

中文名称:网格蛋白轻链 A

种属: Homo sapiens

同用名: LCA

基因 ID: 1211 | 基因类型: protein coding

关于 CLTA

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:36,190,874-36,212,059 (from NCBI)

This gene has 8 transcripts (splice variants), 213 orthologues and 1 paralogue. Ubiquitous expression in colon (RPKM 66.3), kidney (RPKM 59.1) and 25 other tissues.

功能概要

网格蛋白是由重链和轻链组成的大型可溶性蛋白质。它作为涂层凹坑和囊泡的格子型细胞质面的主要结构成分,在受体介导的内吞作用过程中捕获特定的大分子。该基因编码两种网格蛋白轻链蛋白中的一种,据信其起调节元件的作用。可变剪接导致多个转录本变体。已在 8 号和 12 号染色体上鉴定出相关假基因。[RefSeq 提供,2010 年 5 月]

Clathrin is a large, soluble protein composed of heavy and LIGHT chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin LIGHT chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, May 2010]

CLTA 基因产物(10)

mRNA Protein Name
NM_001076677.3 NP_001070145.1 clathrin light chain A isoform c
NM_001184760.2 NP_001171689.1 clathrin light chain A isoform d
NM_001184761.2 NP_001171690.1 clathrin light chain A isoform e
NM_001184762.2 NP_001171691.1 clathrin light chain A isoform f
NM_001311203.2 NP_001298132.1 clathrin light chain A isoform g
NM_001311204.2 NP_001298133.1 clathrin light chain A isoform h
NM_001311205.2 NP_001298134.1 clathrin light chain A isoform i
NM_001311206.2 NP_001298135.1 clathrin light chain A isoform j
NM_001833.4 NP_001824.1 clathrin light chain A isoform a
NM_007096.4 NP_009027.1 clathrin light chain A isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables clathrin heavy chain binding IPI
IPI: 通过物理相互作用推断
4066749 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16595675 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in clathrin coat assembly IMP
IMP: 通过突变表型推断
11756460 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of clathrin coat IMP
IMP: 通过突变表型推断
11756460 GOA
part of clathrin complex IDA
IDA: 通过直接分析推断
4066749 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CLTA 蛋白结构

Clathrin_lg_ch

Clathrin_lg_ch: Clathrin light chain (20 - 247)

  • 0
  • 100
  • 200
  • 248 a.a.
蛋白主名 其他名称

clathrin light chain A

clathrin, light polypeptide (Lca)

CLTA 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CLTA P09496 CALY Homo sapiens Q9NYX4
Confocal
16595675
Intra CLTA P09496 CALY Homo sapiens Q9NYX4
Y2H
16595675
Intra CLTA P09496 CALY Homo sapiens Q9NYX4
Pull Down
16595675
Intra CLTA P09496 TACC3 Homo sapiens Q9Y6A5
Anti Bait CoIP
21297582
Intra CLTA P09496 CLTC Homo sapiens Q00610
Anti Tag CoIP
35271311
Intra CLTA P09496 CLTC Homo sapiens Q00610
Anti Bait CoIP
21297582
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Bos taurus CLTA VGNC VGNC:27469
Rattus norvegicus CLTA RGD RGD:70919
Canis familiaris CLTA VGNC VGNC:39365
Mus musculus CLTA MGD MGI:894297
Felis catus CLTA VGNC VGNC:60982
Macaca mulatta CLTA VGNC VGNC:71266