1. Gene
  2. CALY - calcyon neuron specific vesicular protein Gene

CALY - calcyon neuron specific vesicular protein Gene

中文名称:钙质细胞神经元特异性囊泡蛋白

种属: Homo sapiens

同用名: NSG3; DRD1IP

基因 ID: 50632 | 基因类型: protein coding

关于 CALY

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:133,324,072-133,336,896 (from NCBI)

This gene has 5 transcripts (splice variants), 169 orthologues and 2 paralogues. Biased expression in brain (RPKM 10.6), adrenal (RPKM 3.4) and 1 other tissue.

功能概要

该基因编码的蛋白质是 II 型单跨膜蛋白。在嘌呤能或毒蕈碱而非 β-肾上腺素能受体受到刺激后,它是最大刺激钙释放所必需的。编码的蛋白质与 D1 多巴胺受体相互作用,并可能与其他 DA 受体亚型和/或 GPCR 相互作用。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with D1 Dopamine Receptor and may interact with Other DA receptor subtypes and/or GPCRs. [provided by RefSeq, Jul 2008]

CALY 基因产物(2)

mRNA Protein Name
NM_001321617.2 NP_001308546.1 neuron-specific vesicular protein calcyon isoform 2
NM_015722.4 NP_056537.1 neuron-specific vesicular protein calcyon isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables clathrin light chain binding IDA
IDA: 通过直接分析推断
16595675 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16595675 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in clathrin coat assembly IDA
IDA: 通过直接分析推断
16595675 GOA
involved in positive regulation of endocytosis IMP
IMP: 通过突变表型推断
16595675 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
14534309 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
14534309 GOA
is active in postsynaptic endocytic zone IDA
IDA: 通过直接分析推断
16595675 GOA
is active in postsynaptic endocytic zone IMP
IMP: 通过突变表型推断
16595675 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CALY 蛋白结构

Calcyon

Calcyon: D1 dopamine receptor-interacting protein (calcyon) (1 - 197)

  • 0
  • 100
  • 200
  • 217 a.a.
蛋白主名 其他名称

neuron-specific vesicular protein calcyon

D1 dopamine receptor-interacting protein

CALY 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CALY Q9NYX4 CLTA Homo sapiens P09496
Anti Tag CoIP
16595675
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Childhood Pilocytic Astrocytoma

Pediatric Pilocytic Astrocytoma

Glutaric Aciduria Iii

Glutaryl-Coa Oxidase Deficiency

Ga Iii

Glutaric Acidemia Type 3

GA3

Glutaric Aciduria Type 3

Glutaric Aciduria 3

Glutaric Acidemia Type Iii

Glutaric Aciduria Type Iii

Malignant Essential Hypertension

Accelerated Essential Hypertension

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus CALY VGNC VGNC:26718
Macaca mulatta CALY VGNC VGNC:70575
Rattus norvegicus CALY RGD RGD:621719
Canis familiaris CALY VGNC VGNC:38676
Mus musculus CALY MGD MGI:1915816
Others CALY NCBI