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  4. YM-355179 fumarate

YM-355179 fumarate是一种新合成的选择性CCR3拮抗剂，具有抑制嗜酸性粒细胞相关过敏性炎症疾病的潜力。YM-355179可以有效抑制CCL11及CCL5对CCR3表达细胞的结合，IC50值分别为7.6 nM和24 nM。YM-355179在功能实验中，能够抑制CCL11诱导的细胞内Ca(2+)流入、趋化性和嗜酸性粒细胞去颗粒化，IC50值分别为8.0 nM、24 nM和29 nM。

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YM-355179 fumarate Chemical Structure

YM-355179 fumarate Chemical Structure

CAS No. : 887647-69-0

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YM-355179 fumarate 相关抗体

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生物活性

YM-355179 fumarate is a newly synthesized selective CCR3 antagonist with the potential to inhibit eosinophil-related allergic inflammatory diseases. YM-355179 can effectively inhibit the binding of CCL11 and CCL5 to CCR3-expressing cells, with IC50 values of 7.6 nM and 24 nM respectively. In functional experiments, YM-355179 can inhibit CCL11-induced intracellular Ca(2+) influx, chemotaxis and eosinophil degranulation, IC50 The values are 8.0 nM, 24 nM and 29 nM respectively[1].

分子量

618.65

Formula

C33H35FN4O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
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YM-355179 fumarate 相关分类

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Keywords:

YM-355179887647-69-0YM355179YM 355179OthersInhibitorinhibitorinhibit

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产品名称：
YM-355179 fumarate
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HY-111198
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