A2780
|
GI50 |
0.32 μM
Compound: CA-4P; 3
|
Antiproliferative activity against human A2780 cells after 48 hrs by MTT assay
Antiproliferative activity against human A2780 cells after 48 hrs by MTT assay
|
[PMID: 30580241]
|
A-375
|
IC50 |
|
Growth inhibition of human A375 cells measured after 48 hrs by MTS assay
Growth inhibition of human A375 cells measured after 48 hrs by MTS assay
|
[PMID: 27100701]
|
A549
|
IC50 |
|
Growth inhibition of human A549 cells by MTS assay
Growth inhibition of human A549 cells by MTS assay
|
[PMID: 27100701]
|
A549
|
GI50 |
0.16 μM
Compound: CA-4P; 3
|
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
|
[PMID: 30580241]
|
A549
|
IC50 |
|
Antiproliferative activity against human A549 cells after 72 hrs by CCK-8 assay
Antiproliferative activity against human A549 cells after 72 hrs by CCK-8 assay
|
[PMID: 30108925]
|
Bel-7402
|
IC50 |
|
Antiproliferative activity against human Bel-7402 cells measured after 48 hrs by SRB assay
Antiproliferative activity against human Bel-7402 cells measured after 48 hrs by SRB assay
|
[PMID: 32113125]
|
BXPC-3
|
GI50 |
0.23 μg/mL
Compound: 1b, CA4P, Fosbretabulin
|
Growth inhibition of human BxPC3 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human BxPC3 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 22324723]
|
BXPC-3
|
GI50 |
0.23 μg/mL
Compound: CA4P
|
Antitumor activity against human BxPC3 cells by sulforhodamine B assay
Antitumor activity against human BxPC3 cells by sulforhodamine B assay
|
[PMID: 19228038]
|
Caov-3 cell line
|
IC50 |
|
Antiproliferative activity against human Caov3 cells measured after 96 hrs by Celltiter-Glo assay
Antiproliferative activity against human Caov3 cells measured after 96 hrs by Celltiter-Glo assay
|
[PMID: 27718473]
|
CCRF-CEM
|
IC50 |
0.011 μM
Compound: 7; CA-4P
|
Antiproliferative activity against human CEM cells measured after 96 hrs by Coulter counter method
Antiproliferative activity against human CEM cells measured after 96 hrs by Coulter counter method
|
[PMID: 30921759]
|
CCRF-CEM
|
IC50 |
0.011 μM
Compound: 4; CA-4P
|
Antiproliferative activity against human CEM cells after 96 hrs by coulter counting method
Antiproliferative activity against human CEM cells after 96 hrs by coulter counting method
|
[PMID: 29471122]
|
CCRF-CEM
|
IC50 |
95 nM
Compound: CA-4P, combretastatin A4P
|
Antiproliferative activity against human CEM cells after 96 hrs by Coulter counter method
Antiproliferative activity against human CEM cells after 96 hrs by Coulter counter method
|
[PMID: 25626146]
|
DU-145
|
GI50 |
0.0007 μg/mL
Compound: CA4P
|
Antitumor activity against human DU145 cells by sulforhodamine B assay
Antitumor activity against human DU145 cells by sulforhodamine B assay
|
[PMID: 19228038]
|
DU-145
|
IC50 |
|
Growth inhibition of human DU145 cells measured after 48 hrs by MTS assay
Growth inhibition of human DU145 cells measured after 48 hrs by MTS assay
|
[PMID: 27100701]
|
DU-145
|
GI50 |
0.00323 μM
Compound: CA-4P
|
Cytotoxicity against human DU145 cells assessed as growth inhibition measured after 48 hrs by SRB assay
Cytotoxicity against human DU145 cells assessed as growth inhibition measured after 48 hrs by SRB assay
|
[PMID: 31059248]
|
DU-145
|
GI50 |
0.00323 μM
Compound: CA4P
|
Cytotoxicity against human DU145 cells after 48 hrs by SRB assay
Cytotoxicity against human DU145 cells after 48 hrs by SRB assay
|
[PMID: 24183586]
|
DU-145
|
GI50 |
0.0072 μg/mL
Compound: 1b, CA4P, Fosbretabulin
|
Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 22324723]
|
DU-145
|
GI50 |
0.016 μM
Compound: 3, CA4P
|
Cytotoxicity against human DU145 cells by SRB assay
Cytotoxicity against human DU145 cells by SRB assay
|
[PMID: 24016002]
|
HCT-116
|
IC50 |
|
Growth inhibition of human HCT116 cells measured after 48 hrs by MTS assay
Growth inhibition of human HCT116 cells measured after 48 hrs by MTS assay
|
[PMID: 27100701]
|
HCT-116
|
IC50 |
|
Antiproliferative activity against human HCT116 cells after 72 hrs by CCK-8 assay
Antiproliferative activity against human HCT116 cells after 72 hrs by CCK-8 assay
|
[PMID: 30108925]
|
HeLa
|
IC50 |
0.00043 μM
Compound: 2, CA4-P
|
Cytotoxicity against human HeLa cells by MTT assay
Cytotoxicity against human HeLa cells by MTT assay
|
[PMID: 19879758]
|
HeLa
|
IC50 |
0.013 μM
Compound: 7; CA-4P
|
Antiproliferative activity against human HeLa cells measured after 3 days by Coulter counter method
Antiproliferative activity against human HeLa cells measured after 3 days by Coulter counter method
|
[PMID: 30921759]
|
HeLa
|
IC50 |
0.013 μM
Compound: 4; CA-4P
|
Antiproliferative activity against human HeLa cells after 3 days by coulter counting method
Antiproliferative activity against human HeLa cells after 3 days by coulter counting method
|
[PMID: 29471122]
|
HeLa
|
GI50 |
0.019 μM
Compound: CA-4P; 3
|
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
|
[PMID: 30580241]
|
HeLa
|
IC50 |
|
Antiproliferative activity against human HeLa cells after 72 hrs by CCK-8 assay
Antiproliferative activity against human HeLa cells after 72 hrs by CCK-8 assay
|
[PMID: 30108925]
|
HeLa
|
IC50 |
79 nM
Compound: CA-4P, combretastatin A4P
|
Antiproliferative activity against human HeLa cells after 4 days by Coulter counter method
Antiproliferative activity against human HeLa cells after 4 days by Coulter counter method
|
[PMID: 25626146]
|
HepG2
|
IC50 |
|
Antiproliferative activity against human HepG2 cells measured after 48 hrs by SRB assay
Antiproliferative activity against human HepG2 cells measured after 48 hrs by SRB assay
|
[PMID: 32113125]
|
HepG2
|
GI50 |
0.19 μM
Compound: CA-4P; 3
|
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
|
[PMID: 30580241]
|
HepG2
|
IC50 |
|
Antiproliferative activity against human HepG2 cells after 72 hrs by CCK-8 assay
Antiproliferative activity against human HepG2 cells after 72 hrs by CCK-8 assay
|
[PMID: 30108925]
|
HMEC-1
|
IC50 |
0.0029 μM
Compound: 7; CA-4P
|
Antiproliferative activity against human HMEC1 cells measured after 4 days by Coulter counter method
Antiproliferative activity against human HMEC1 cells measured after 4 days by Coulter counter method
|
[PMID: 30921759]
|
HMEC-1
|
IC50 |
0.0029 μM
Compound: 4; CA-4P
|
Antiproliferative activity against human HMEC1 cells after 4 days by coulter counting method
Antiproliferative activity against human HMEC1 cells after 4 days by coulter counting method
|
[PMID: 29471122]
|
HMEC-1
|
IC50 |
2.9 nM
Compound: CA-4P, combretastatin A4P
|
Antiproliferative activity against human HMEC1 cells after 4 days by Coulter counter method
Antiproliferative activity against human HMEC1 cells after 4 days by Coulter counter method
|
[PMID: 25626146]
|
HT-29
|
GI50 |
0.062 μM
Compound: CA-4P; 3
|
Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay
Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay
|
[PMID: 30580241]
|
HUVEC
|
GI50 |
|
Growth inhibition of HUVEC after 72 hrs by crystal violet staining-based assay
Growth inhibition of HUVEC after 72 hrs by crystal violet staining-based assay
|
[PMID: 27690431]
|
Jurkat
|
EC50 |
15 nM
Compound: CA4P, Zybrestat
|
Cytotoxicity against human Jurkat cells assessed as cell viability after 48 hrs by trypan blue exclusion assay
Cytotoxicity against human Jurkat cells assessed as cell viability after 48 hrs by trypan blue exclusion assay
|
[PMID: 24387982]
|
K562
|
IC50 |
|
Cytotoxicity against human K562 cells assessed as growth inhibition after 5 days by MTT assay
Cytotoxicity against human K562 cells assessed as growth inhibition after 5 days by MTT assay
|
[PMID: 28143677]
|
KM-20L2
|
GI50 |
0.034 μg/mL
Compound: 1b, CA4P, Fosbretabulin
|
Growth inhibition of human KM20L2 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human KM20L2 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 22324723]
|
KM-20L2
|
GI50 |
0.034 μg/mL
Compound: 1b, CA4P
|
Cytotoxicity against human KM20L2 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human KM20L2 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 16252907]
|
L1210
|
IC50 |
0.0021 μM
Compound: 4; CA-4P
|
Antiproliferative activity against mouse L1210 cells after 96 hrs by coulter counting method
Antiproliferative activity against mouse L1210 cells after 96 hrs by coulter counting method
|
[PMID: 29471122]
|
L1210
|
IC50 |
0.013 μM
Compound: 7; CA-4P
|
Antiproliferative activity against mouse L1210 cells measured after 96 hrs by Coulter counter method
Antiproliferative activity against mouse L1210 cells measured after 96 hrs by Coulter counter method
|
[PMID: 30921759]
|
L1210
|
IC50 |
82 nM
Compound: CA-4P, combretastatin A4P
|
Antiproliferative activity against mouse L1210 cells after 48 hrs by Coulter counter method
Antiproliferative activity against mouse L1210 cells after 48 hrs by Coulter counter method
|
[PMID: 25626146]
|
MCF7
|
IC50 |
0.002 μM
Compound: 2, CA4-P
|
Cytotoxicity against human MCF7 cells by MTT assay
Cytotoxicity against human MCF7 cells by MTT assay
|
[PMID: 19879758]
|
MCF7
|
IC50 |
|
Antiproliferative activity against human MCF7 cells measured after 48 hrs by SRB assay
Antiproliferative activity against human MCF7 cells measured after 48 hrs by SRB assay
|
[PMID: 32113125]
|
MCF7
|
IC50 |
|
Antiproliferative activity against human MCF7 cells after 72 hrs by CCK-8 assay
Antiproliferative activity against human MCF7 cells after 72 hrs by CCK-8 assay
|
[PMID: 30108925]
|
MDA-MB-231
|
IC50 |
|
Growth inhibition of human MDA-MB-231 cells measured after 48 hrs by MTS assay
Growth inhibition of human MDA-MB-231 cells measured after 48 hrs by MTS assay
|
[PMID: 27100701]
|
MDA-MB-231
|
GI50 |
0.065 μM
Compound: CA-4P; 3
|
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
|
[PMID: 30580241]
|
MDA-MB-231
|
IC50 |
|
Antiproliferative activity against human MDA-MB-231 cells measured after 96 hrs by Celltiter-Glo assay
Antiproliferative activity against human MDA-MB-231 cells measured after 96 hrs by Celltiter-Glo assay
|
[PMID: 27718473]
|
MDA-MB-435
|
IC50 |
|
Antiproliferative activity against human MDA-MB-435 cells measured after 96 hrs by Celltiter-Glo assay
Antiproliferative activity against human MDA-MB-435 cells measured after 96 hrs by Celltiter-Glo assay
|
[PMID: 27718473]
|
MGC-803
|
IC50 |
|
Antiproliferative activity against human MGC803 cells after 72 hrs by CCK-8 assay
Antiproliferative activity against human MGC803 cells after 72 hrs by CCK-8 assay
|
[PMID: 30108925]
|
NCI-H460
|
GI50 |
0.0004 μg/mL
Compound: CA4P
|
Antitumor activity against human NCI-H460 cells by sulforhodamine B assay
Antitumor activity against human NCI-H460 cells by sulforhodamine B assay
|
[PMID: 19228038]
|
NCI-H460
|
GI50 |
0.00194 μM
Compound: CA-4P
|
Cytotoxicity against human NCI-H460 cells assessed as growth inhibition measured after 48 hrs by SRB assay
Cytotoxicity against human NCI-H460 cells assessed as growth inhibition measured after 48 hrs by SRB assay
|
[PMID: 31059248]
|
NCI-H460
|
GI50 |
0.00194 μM
Compound: CA4P
|
Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay
Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay
|
[PMID: 24183586]
|
NCI-H460
|
GI50 |
0.029 μg/mL
Compound: 1b, CA4P, Fosbretabulin
|
Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 22324723]
|
NCI-H460
|
GI50 |
0.029 μg/mL
Compound: 1b, CA4P
|
Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 16252907]
|
NCI-H460
|
GI50 |
0.066 μM
Compound: 3, CA4P
|
Cytotoxicity against human NCI-H460 cells by SRB assay
Cytotoxicity against human NCI-H460 cells by SRB assay
|
[PMID: 24016002]
|
P388
|
ED50 |
0.0004 μg/mL
Compound: 1b, CA4P
|
Cytotoxicity against mouse P388 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against mouse P388 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 16252907]
|
P388
|
ED50 |
0.0004 μg/mL
Compound: 1b, CA4P, Fosbretabulin
|
Growth inhibition of mouse P388 cells after 48 hrs by Z1 Beckman/Coulter particle counter analysis
Growth inhibition of mouse P388 cells after 48 hrs by Z1 Beckman/Coulter particle counter analysis
|
[PMID: 22324723]
|
PBMC
|
IC50 |
|
Growth inhibition of human PBMC cells measured after 48 hrs by MTS assay
Growth inhibition of human PBMC cells measured after 48 hrs by MTS assay
|
[PMID: 27100701]
|
PC-3
|
IC50 |
|
Growth inhibition of human PC3 cells measured after 48 hrs by MTS assay
Growth inhibition of human PC3 cells measured after 48 hrs by MTS assay
|
[PMID: 27100701]
|
SF-268
|
GI50 |
0.036 μg/mL
Compound: 1b, CA4P, Fosbretabulin
|
Growth inhibition of human SF268 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human SF268 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 22324723]
|
SF-268
|
GI50 |
0.036 μg/mL
Compound: 1b, CA4P
|
Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 16252907]
|
SK-OV-3
|
GI50 |
0.00119 μM
Compound: CA-4P
|
Cytotoxicity against human SKOV3 cells assessed as growth inhibition measured after 48 hrs by SRB assay
Cytotoxicity against human SKOV3 cells assessed as growth inhibition measured after 48 hrs by SRB assay
|
[PMID: 31059248]
|
SK-OV-3
|
GI50 |
0.00119 μM
Compound: CA4P
|
Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay
Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay
|
[PMID: 24183586]
|
SK-OV-3
|
IC50 |
|
Growth inhibition of human SKOV3 cells measured after 48 hrs by MTS assay
Growth inhibition of human SKOV3 cells measured after 48 hrs by MTS assay
|
[PMID: 27100701]
|
TOV112D
|
IC50 |
|
Antiproliferative activity against human TOV112D cells measured after 96 hrs by Celltiter-Glo assay
Antiproliferative activity against human TOV112D cells measured after 96 hrs by Celltiter-Glo assay
|
[PMID: 27718473]
|