Fosbretabulin (Synonyms: Combretastatin A4 phosphate)

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Fosbretabulin (Combretastatin A4 phosphate) 是一种血管破坏剂，对不典型甲状腺癌 (ATC) 的细胞系和移植瘤具有抗肿瘤活性。Fosbretabulin 通过抑制微管聚合，诱导细胞凋亡 (apoptosis) 并抑制肿瘤中的血管生成来抑制肿瘤生长。

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Fosbretabulin Chemical Structure

CAS No. : 222030-63-9

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Fosbretabulin 的其他形式现货产品:

Fosbretabulin disodium

Other Forms of Fosbretabulin:

Fosbretabulin disodium In-stock
Fosbretabulin tromethamine 询价

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生物活性
纯度 & 产品资料
参考文献

生物活性

Fosbretabulin (Combretastatin A4 phosphate) is a vascular disruptor with antitumor activity against atypical thyroid carcinoma (ATC) cell lines and xenografts. Fosbretabulin inhibits tumor growth by inhibiting microtubule polymerization, inducing apoptosis, and suppressing angiogenesis in tumors^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A10	EC₅₀	7 nM Compound: CA4P	Inhibition of microtubule depolymerization in rat A10 cells assessed as reorganization of interphase microtubule network by indirect immunofluorescence technique Inhibition of microtubule depolymerization in rat A10 cells assessed as reorganization of interphase microtubule network by indirect immunofluorescence technique	[PMID: 20973488]
DU-145	GI₅₀	0.00336 μM Compound: CA4P	Growth inhibition of human DU145 cells after 48 hrs by SRB assay Growth inhibition of human DU145 cells after 48 hrs by SRB assay	[PMID: 28217276]
EA.hy 926	IC₅₀	6.4 μM Compound: CA4P	Antiproliferative activity against human EAhy926 cells after 48 hrs by MTT assay Antiproliferative activity against human EAhy926 cells after 48 hrs by MTT assay	10.1039/C6MD00360E
EA.hy 926	IC₅₀	6.4 μM Compound: CA4P	Antiproliferative activity against human EAhy926 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human EAhy926 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 27597243]
EA.hy 926	IC₅₀	6.4 μM Compound: CA4P	Antiproliferative activity against human EAhy926 cells measured after 48 hrs by MTT assay Antiproliferative activity against human EAhy926 cells measured after 48 hrs by MTT assay	[PMID: 27592394]
HCT-116	IC₅₀	0.042 μM Compound: CA-4P	Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 32682200]
HeLa	IC₅₀	4.7 nM Compound: CA4P	Antiproliferative activity against human HeLa cells by sulforhodamine B assay Antiproliferative activity against human HeLa cells by sulforhodamine B assay	[PMID: 20973488]
HeLa	IC₅₀	5.7 nM Compound: CA4P	Antiproliferative activity against human HeLa cells expressing tubulin 3beta by sulforhodamine B assay Antiproliferative activity against human HeLa cells expressing tubulin 3beta by sulforhodamine B assay	[PMID: 20973488]
MGC-803	IC₅₀	0.02 μM Compound: CA-4P	Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 32682200]
NCI-H460	GI₅₀	0.00282 μM Compound: CA4P	Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 28217276]
PC-3	IC₅₀	0.033 μM Compound: CA-4P	Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 32682200]
SK-OV-3	GI₅₀	0.0019 μM Compound: CA4P	Growth inhibition of human SKOV3 cells after 48 hrs by SRB assay Growth inhibition of human SKOV3 cells after 48 hrs by SRB assay	[PMID: 28217276]
SK-OV-3	IC₅₀	4.5 nM Compound: CA4P	Antiproliferative activity against human SKOV3 cells by sulforhodamine B assay Antiproliferative activity against human SKOV3 cells by sulforhodamine B assay	[PMID: 20973488]
SK-OV-3	IC₅₀	6.6 nM Compound: CA4P	Antiproliferative activity against human SKOV3 cells expressing MDR1-6/6 by sulforhodamine B assay Antiproliferative activity against human SKOV3 cells expressing MDR1-6/6 by sulforhodamine B assay	[PMID: 20973488]

分子量

396.33

Formula

C₁₈H₂₁O₈P

CAS 号

222030-63-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Mooney, et al. "A phase II trial of fosbretabulin in advanced anaplastic thyroid carcinoma and correlation of baseline serum-soluble intracellular adhesion molecule-1 with outcome." Thyroid 19.3 (2009): 233-240. [Content Brief]

Fosbretabulin 相关分类

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fosbretabulin222030-63-9Combretastatin A4Combretastatin A 4Combretastatin A-4ApoptosisMicrotubule/TubulinVascular damagemicrotubule polymerizationapoptosisthyroid cancerInhibitorinhibitorinhibit

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Fosbretabulin (Synonyms: Combretastatin A4 phosphate)

Other Forms of Fosbretabulin:

Fosbretabulin 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

纯度 & 产品资料

参考文献

Fosbretabulin 相关分类

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The molarity calculator equation

The dilution calculator equation

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Fosbretabulin (Synonyms: Combretastatin A4 phosphate)

Other Forms of Fosbretabulin:

Fosbretabulin 相关抗体

Fosbretabulin 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

纯度 & 产品资料

参考文献

Fosbretabulin 相关分类

摩尔计算器

稀释计算器

The molarity calculator equation

The dilution calculator equation

Keywords:

您最近查看的产品:

Request for HNMR Report

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