2. Academic Validation
  3. Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs

Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs

  • Bioorg Med Chem Lett. 2009 Dec 15;19(24):6948-51. doi: 10.1016/j.bmcl.2009.10.064.
Rita Fürst 1,  István Zupkó,  Agnes Berényi,  Gerhard F Ecker,  Uwe Rinner
Affiliations

Affiliation

  • 1 Department of Organic Chemistry, University of Vienna, Währinger Strasse 38, 1090 Vienna, Austria.
PMID: 19879758 DOI: 10.1016/j.bmcl.2009.10.064
Abstract

Several derivatives of combretastatin have been prepared bearing a cyclopropyl unit instead of the natural occurring cis-double bond. Final products and synthetic intermediates were evaluated for their cytotoxic properties in two human Cancer cell lines.

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