2. GPCR/G Protein
  3. EBI2/GPR183
  4. GPR183-IN-1

GPR183-IN-1 (compound 15) 是一种有效的和具有口服活性的 GPR183 抑制剂。GPR183-IN-1 抑制 Ca2+ 动员，IC50 值为 39.97 nM。GPR183-IN-1 具有用于癌症、自身免疫性疾病、疼痛和骨质疏松症研究的潜力。

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GPR183-IN-1 Chemical Structure

GPR183-IN-1 Chemical Structure

CAS No. : 2924063-70-5

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GPR183-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GPR183-IN-1 (compound 15) is a potent and orally activity GPR183 inhibitor. GPR183-IN-1 inhibits Ca2+ mobilization with an IC50 value of 39.97 nM. GPR183-IN-1 has the potential for the research of cancer, autoimmune diseases, pain, and osteoporosis[1].

体内研究
(In Vivo)

药代动力学分析[1].

Parameters CL (mL/min/kg) T1/2 (h) Cmax (ng/mL) AUC0-t (ng·h/mL) Vss (L/kg) F (%)
IV 1 mg/kg 32.56 0.69 934.25 513.00 1.53 -
PO 10 mg/kg - 1.25 3026.21 6819.57 - 133.21

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

351.24

Formula

C16H19BrN2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GPR183-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPR183-IN-12924063-70-5EBI2/GPR183orally activityCa2+ mobilizationU937 cellscancerautoimmune diseasespainosteoporosisInhibitorinhibitorinhibit

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