2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Catharanthine Sulfate

Catharanthine Sulfate  (Synonyms: 硫酸长春质碱; (+)-3,4-Didehydrocoronaridine Sulfate)

目录号: HY-N0252B
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Catharanthine ((+)-3,4-Didehydrocoronaridine) Sulfate 是抗癌长春花生物碱的一种成分，可抑制电压驱动的 L 型 Ca2+ 通道 (VOCC)。Catharanthine Sulfate 对心肌细胞和血管平滑肌细胞 (VSMC) 中 VOCC 电流的 IC50 分别为 220 μM 和 8 μM。Catharanthine Sulfate 可降低血压 (BP)、心率 (HR)。Catharanthine Sulfate 具有抗癌活性。

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Catharanthine Sulfate Chemical Structure

Catharanthine Sulfate Chemical Structure

CAS No. : 153230-94-5

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Other Forms of Catharanthine Sulfate:

Catharanthine Sulfate 相关抗体

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Catharanthine ((+)-3,4-Didehydrocoronaridine) Sulfate, a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca2+ channel (VOCC). Catharanthine Sulfate has IC50s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine Sulfate lowers blood pressure (BP), heart rate (HR). Catharanthine Sulfate has anti-cancer activity[1][2].

IC50 & Target

L-type calcium channel

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 IC50
> 50 μM
Compound: Catharanthine sulfate
Cytotoxicity against adriamycin-resistant human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against adriamycin-resistant human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 23708010]
HepG2 IC50
> 50 μM
Compound: Catharanthine sulfate
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 23708010]
K562 IC50
> 50 μM
Compound: Catharanthine sulfate
Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 23708010]
MCF7 IC50
> 50 μM
Compound: Catharanthine sulfate
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 23708010]
MDA-MB-231 IC50
> 50 μM
Compound: Catharanthine sulfate
Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 23708010]
体内研究
(In Vivo)

Catharanthine ((+)-3,4-Didehydrocoronaridine；0.5-20 mg/kg；静脉给药；单剂量) Sulfate 可引起血压和心率的剂量依赖性降低[1]。
Catharanthine (40 mg/kg；腹腔注射；单剂量) Sulfate 急性给药在 1 小时和 24 小时在雄性和雌性小鼠中诱导类似的抗抑郁样活性[2]。
Catharanthine (20 mg/kg；腹腔注射；连续 14 天) Sulfate 在 D7 或 D14 增加小鼠游泳时间并减少不动时间[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 13-week-old male SpragueDawley rats (300-350 g)[1]
Dosage: 0.5-20 mg/kg
Administration: IV; single dose
Result: Evoked rapid, transient reductions in BP and HR (lasting ,2 minutes) at low doses (0.5–5 mg/kg), whereas at higher doses (10 and 20 mg/kg), the BP and HR reductions were sustained.
分子量

434.51

Formula

C21H26N2O6S
CAS 号
中文名称

硫酸长春质碱
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Catharanthine Sulfate 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Catharanthine153230-94-5(+)-3,4-Didehydrocoronaridine硫酸长春质碱Calcium ChannelCa2+ channelsCa channelsAnticancervincaalkaloidsvoltage-operated L-typeVOCCcardiomyocytesvascular smooth muscle cellsVSMCsblood pressureheart rateInhibitorinhibitorinhibit

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