2. Apoptosis
  3. MDM-2/p53
  4. S100A2-p53-IN-1

S100A2-p53-IN-1 (化合物 51) 是一种 S100A2-p53 相互作用抑制剂。S100A2 是一种 Ca2+ 结合蛋白，与细胞信号传导有关，已知在胰腺癌中上调。S100A2-p53-IN-1 可以抑制 MiaPaCa-2 胰腺癌细胞系的生长 (GI50 of 1.2-3.4 μM)。

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S100A2-p53-IN-1 Chemical Structure

S100A2-p53-IN-1 Chemical Structure

CAS No. : 2766609-08-7

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S100A2-p53-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

S100A2-p53-IN-1 (compound 51) is a S100A2-p53 interactions inhibitor. S100A2 is a Ca2+ binding protein with implications in cell signaling and is known to be upregulated in pancreatic cancer. S100A2-p53-IN-1 can inhibit the growth of the MiaPaCa-2 pancreatic cancer cell line (GI50 of 1.2-3.4 μM)[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A2780 GI50
1.5 μM
Compound: 51
Growth inhibition of human A2780 cells incubated for 72 hrs by MTT assay
Growth inhibition of human A2780 cells incubated for 72 hrs by MTT assay
[PMID: 35114371]
ASPC1 GI50
2.9 μM
Compound: 51
Growth inhibition of human ASPC1 cells incubated for 72 hrs by MTT assay
Growth inhibition of human ASPC1 cells incubated for 72 hrs by MTT assay
[PMID: 35114371]
BE(2)-C GI50
2.8 μM
Compound: 51
Growth inhibition of human BE2C cells incubated for 72 hrs by MTT assay
Growth inhibition of human BE2C cells incubated for 72 hrs by MTT assay
[PMID: 35114371]
BXPC-3 GI50
1.2 μM
Compound: 51
Growth inhibition of human BXPC-3 cells incubated for 72 hrs by MTT assay
Growth inhibition of human BXPC-3 cells incubated for 72 hrs by MTT assay
[PMID: 35114371]
Capan-2 GI50
2.5 μM
Compound: 51
Growth inhibition of human Capan-2 cells incubated for 72 hrs by MTT assay
Growth inhibition of human Capan-2 cells incubated for 72 hrs by MTT assay
[PMID: 35114371]
HPAC GI50
2.7 μM
Compound: 51
Growth inhibition of human HPAC cells incubated for 72 hrs by MTT assay
Growth inhibition of human HPAC cells incubated for 72 hrs by MTT assay
[PMID: 35114371]
HT-29 GI50
2.2 μM
Compound: 51
Growth inhibition of human HT-29 cells incubated for 72 hrs by MTT assay
Growth inhibition of human HT-29 cells incubated for 72 hrs by MTT assay
[PMID: 35114371]
MCF-10A GI50
3.2 μM
Compound: 51
Growth inhibition of human MCF-10A cells incubated for 72 hrs by MTT assay
Growth inhibition of human MCF-10A cells incubated for 72 hrs by MTT assay
[PMID: 35114371]
MCF7 GI50
2.5 μM
Compound: 51
Growth inhibition of human MCF7 cells incubated for 72 hrs by MTT assay
Growth inhibition of human MCF7 cells incubated for 72 hrs by MTT assay
[PMID: 35114371]
MIA PaCa-2 GI50
2.6 μM
Compound: 51
Growth inhibition of human MIA PaCa-2 cells incubated for 72 hrs by MTT assay
Growth inhibition of human MIA PaCa-2 cells incubated for 72 hrs by MTT assay
[PMID: 35114371]
PANC-1 GI50
3.4 μM
Compound: 51
Growth inhibition of human PANC-1 cells incubated for 72 hrs by MTT assay
Growth inhibition of human PANC-1 cells incubated for 72 hrs by MTT assay
[PMID: 35114371]
分子量

498.44

Formula

C20H20F6N2O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

S100A2-p53-IN-1 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S100A2-p53-IN-12766609-08-7MDM-2/p53S100A2-p53pancreatic cancerInhibitorinhibitorinhibit

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