2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. CA IX-IN-1

CA IX-IN-1 (compound 12g) 是一种有效的高选择性 hCA IX 抑制剂，其 IC50 值为 7 nM。CA-IX-IN-1 具有抗肿瘤活性。

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CA IX-IN-1 Chemical Structure

CA IX-IN-1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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CA IX-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Carbonic Anhydrase 亚型特异性产品:

查看所有亚型
CA CA I CA Ⅱ CA Ⅸ CA XII

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CA IX-IN-1 (compound 12g) is an effective and selective inhibitor of hCA IX with IC50 value of 7 nM. CA IX-IN-1 exhibits antitumor activity[1].

体外研究
(In Vitro)

CA IX-IN-1 (compound 12g) displays effective inhibition against hCA I, hCA II and hCA IX with IC50 values of 4, 0.018, 0.007 μM, respectively[1].
CA IX-IN-1 (compound 12g) (0.1 μM, 72 hours; HT-29 and MDA-MB-231 cells) exerts the potent antitumor activities against human cancer cell lines[1].
CA IX-IN-1 (compound 12g) (0-1 mM, 48 hours; HT-29 and MDA-MB-231 cells) induces highly expression level and enzyme activity of HCA IX in tumor cells with enhance the acidification of extracellular pH[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CA IX-IN-1 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HT-29 (colon carcinoma cells) and MDA-MB-231 (breast cancer cells)
Concentration: 0.1 mM
Incubation Time: 72 hours
Result: Revealed antitumor activity against HT-29 and MDA-MB-231 (IC50 = 32 and 31 μM respectively).

Cell Cytotoxicity Assay[1]

Cell Line: MDA-MB-231 (breast cancer cells)
Concentration: 0.1 μM
Incubation Time: 72 hours
Result: Decreased (20–35%) of IC50 values were detected compared with that obtained for DOX alone.
分子量

430.43

Formula

C16H22N4O8S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CA IX-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CA IX-IN-1Carbonic AnhydraseCarbonate dehydratasehCA IXcarbonic anhydrasesanticancerInhibitorinhibitorinhibit

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产品名称：
CA IX-IN-1
目录号：
HY-149011
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