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  3. AMD 3329 octahydrobromide

AMD 3329 octahydrobromide是一种强效且选择性的抗HIV-1和HIV-2化合物,具有抑制病毒复制的活性。AMD 3329通过与化学趋化因子受体CXCR4结合来阻止病毒入侵。AMD 3329在抑制HIV-1和HIV-2复制时表现出低至0.8和1.6 nM的EC50值,显示出优于AMD3100的抗病毒效果。AMD 3329对特定的CXCR4单克隆抗体的结合及由SDF-1alpha诱导的Ca(2+)通量有显著抑制作用。AMD 3329还能够有效干扰病毒诱导的合胞体形成,EC50值为12 nM。

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AMD 3329 octahydrobromide Chemical Structure

AMD 3329 octahydrobromide Chemical Structure

CAS No. : 170861-77-5

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生物活性

AMD 3329 octahydrobromide is a potent and selective anti-HIV-1 and HIV-2 compound with activity to inhibit viral replication. AMD 3329 blocks viral invasion by binding to the chemokine receptor CXCR4. AMD 3329 exhibits EC50 values as low as 0.8 and 1.6 nM when inhibiting HIV-1 and HIV-2 replication, showing better antiviral efficacy than AMD3100. AMD 3329 significantly inhibits the binding of specific CXCR4 monoclonal antibodies and the Ca(2+) flux induced by SDF-1alpha. AMD 3329 is also able to effectively interfere with virus-induced syncytium formation, with an EC50 value of 12 nM[1].

分子量

1218.11

Formula

C34H58Br8N8

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

AMD 3329 octahydrobromide 相关分类

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AMD 3329 octahydrobromide
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