2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Iganidipine

Iganidipine  (Synonyms: 伊加地平)

目录号: HY-101685
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摩尔计算器

Iganidipine 是一种钙离子通道拮抗剂。

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Iganidipine Chemical Structure

Iganidipine Chemical Structure

CAS No. : 119687-33-1

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Iganidipine 相关抗体

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查看 Calcium Channel 亚型特异性产品:

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Iganidipine is a Ca2+ antagonist.

IC50 & Target

Ca2+[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Ventricular myocyte IC50
0.009 μM
Compound: NKY-722
Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes
Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes
[PMID: 22761000]
体内研究
(In Vivo)

Iganidipine (0.03% solution) significantly increases optic nerve head (ONH) tissue blood velocity (NBONH) by 8 to 10% in treated eyes after a single administration (p<0.05) or by 18 to 35% after 7-, 14-, or 21-day twicedaily administration in rabbits (p<0.05). In monkeys, 0.03% and 0.1% Iganidipine significantly increases NBONH in treated eyes by 20 and 41% after 7-day (p<0.05) twice-daily administration, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

526.62

Formula

C28H38N4O6
CAS 号
中文名称

伊加地平
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Animal Administration
[1]

Monkeys[1]
Five adult cynomolgus monkeys (age, 5-8 years; weight, 3-5 kg; sex, 5 males) are used. All examinations are performed with the monkeys sitting in a modified monkey chair. On the first experimental day, after general anesthesia is induced by Ketamine hydrochloride at a dose of 8 to 10 mg/kg intramuscularly, pupil dilation is induced with one drop of Tropicamide in both eyes. The NBONH, IOP, blood pressure, pulse rate, SaO2, and body temperature are measured at 9AM. Starting on the 2nd experimental day, Iganidipine (0.03% or 0.1%, 30 mL) is administered in one randomly chosen eye and vehicle solution into the other eye twice daily at 8AM and 8PM for 7 days. At 9AM on the 8th experimental day, the same measurements are repeated after general anesthesia and bilateral pupil dilation. After a 4-week interval, a second series of experiments is performed using a different Iganidipine concentration according to the same time schedule.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Iganidipine 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Iganidipine119687-33-1伊加地平Calcium ChannelCa2+ channelsCa channelsInhibitorinhibitorinhibit

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