2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. CXL-1020

CXL-1020 是一种基于羟胺基的硝基 (HNO) 供体。CXL-1020 改善舒张异常大鼠的心肌收缩性/舒张性和 Ca2+ 循环。CXL-1020 在犬模型中诱导血管舒张，改善心脏功能。CXL-1020 已被用于研究收缩期心力衰竭和稳定期心力衰竭。

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CXL-1020 Chemical Structure

CXL-1020 Chemical Structure

CAS No. : 950834-06-7

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CXL-1020 相关抗体

Top Publications Citing Use of Products

查看 Calcium Channel 亚型特异性产品:

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CXL-1020 is a hydroxylamine-based nitroxyl (HNO) donor. CXL-1020 improves cardiac inotropy/lusitropy and Ca2+ cycling in rats with abnormal relaxation. CXL-1020 induces vasorelaxation and improves cardiac function in canine models. CXL-1020 has been used to research systolic heart failure and stable heart failure[1].

IC50 & Target[1]

L-type calcium channel

 

体内研究
(In Vivo)

CXL-1020 (100 μg/kg/min; infusion for 30 min) improves hemodynamics and cardiac function, and enhances both diastolic and systolic performance in mice[1].
CXL-1020 (3 and 10 mg/kg/min; 4-hour intravenous infusion) improves left ventricular systolic and diastolic function in dogs with advanced heart failure[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats (250-350 g; induced cardiac dysfunction by isoproterenol)[1]
Dosage: 100 μg/kg/min
Administration: For 30 min
Result: Improved hemodynamics and cardiac function in normal rats, and enhanced both diastolic and systolic performance in cardiac dysfunction mice.
Animal Model: Dogs (coronary microembolization-induced heart failure)[2] 3 and 10 mg/kg/min
Dosage: 3 and 10 mg/kg/min
Administration: 4-hour intravenous infusion
Result: Decreased systolic aortic pressure (AoP) modestly; significantly increased EF and deceleration time of early mitral inflow velocity (DT) and significantly lowered left ventricular (LV) end-systolic volume (ESV), LV end-diastolic pressure (EDP) and end-diastolic wall stress (EDWS) in a dose-dependent manner.
Clinical Trial
分子量

251.28

Formula

C7H9NO5S2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

CXL-1020 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

CXL-1020950834-06-7CXL1020CXL 1020Calcium ChannelCa2+ channelsCa channelscardiac inotropycardiac lusitropyvasorelaxationcardiac functionheart failureInhibitorinhibitorinhibit

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