2. Membrane Transporter/Ion Channel Neuronal Signaling NF-κB Apoptosis
  3. NF-κB Calcium Channel Na+/K+ ATPase Apoptosis
  4. Ouabain

Ouabain 是一种强心苷，具有细胞毒性和抗细胞凋亡 (Apoptosis) 作用。Ouabain 也是 Na+/K+-ATPase 抑制剂。Ouabain 还能够作为生物学诱导剂，引发规律且低频的细胞内钙离子 ([Ca2+]i) 振荡，进而激活转录因子 NF-κB。

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Ouabain Chemical Structure

Ouabain Chemical Structure

CAS No. : 630-60-4

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Ouabain 的其他形式现货产品:

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Ouabain 相关抗体

Top Publications Citing Use of Products

    Ouabain purchased from MCE. Usage Cited in: Med Sci Monit. 2019 Dec 11;25:9426-9434.  [Abstract]

    Ouabain reduces OS cell stemness but has little effects on cell viability. Western blot analysis of the protein levels of critical stemness regulators in OS cells treated with ouabain.

    Ouabain purchased from MCE. Usage Cited in: Med Sci Monit. 2019 Dec 11;25:9426-9434.  [Abstract]

    Ouabain leads to DNA methylation of stemness markers through increasing intracellular Ca2+ concentration. The protein levels of stemness regulators are measured in the OS cells described in

    查看 NF-κB 亚型特异性产品:

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    NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

    查看 Calcium Channel 亚型特异性产品:

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    N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Ouabain is a cardiac glycoside possessing cytotoxicity and anti-apoptotic effects. Ouabain is also an inhibitor of Na+/K+-ATPase. Additionally, Ouabain can act as a biological inductor, triggering regular and low-frequency oscillations of intracellular calcium ions ([Ca2+]i), which in turn may activate the transcription factor NF-κB[1][2].

    分子量

    584.65

    Formula

    C29H44O12
    CAS 号
    结构分类
    初始来源
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Ouabain 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ouabain630-60-4NF-κBCalcium ChannelNa+/K+ ATPaseApoptosisNuclear factor-κBNuclear factor-kappaBCa2+ channelsCa channelsSodium potassium pumpcardio tonic steroidscell deathNA,K-ATPaseintracellular NA+ and K+intracellular signalingInhibitorinhibitorinhibit

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    目录号：
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